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Carnosic acid: a potent chemopreventive agent against oral carcinogenesis.
Chem Biol Interact. 2010 Dec 05; 188(3):616-22.CB

Abstract

The present study was aimed to investigate the chemopreventive potential of carnosic acid in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. The chemopreventive potential was assessed by analyzing the tumor incidence, tumor volume and burden as well as by measuring the status of lipid peroxidation, non-enzymatic and enzymatic antioxidants and phase I and phase II detoxification enzymes. Oral squamous cell carcinoma was developed in the buccal pouch of golden Syrian hamsters by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. In the present study, 100% tumor formation was observed in hamsters treated with DMBA alone. Also, the status of lipid peroxidation, antioxidants and phase I and phase II detoxification enzymes were significantly altered during DMBA-induced oral carcinogenesis. Oral administration of carnosic acid at a dose of 10mg/kg body weight/day to DMBA-treated animals completely prevented the tumor formation in the hamsters' buccal pouches. Also, carnosic acid exerted potent anti-lipid peroxidative function and stimulated the detoxification cascade during DMBA-induced hamster buccal pouch carcinogenesis. The results of the present study suggest that the chemopreventive potential of carnosic acid is probably due to its anti-lipid peroxidative potential and modulating effect on carcinogen detoxification enzymes during DMBA-induced oral carcinogenesis.

Authors+Show Affiliations

Department of Biochemistry & Biotechnology, Annamalai University, Cuddalore, Tamil Nadu, India. sakshiman@rediffmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20816777

Citation

Manoharan, Shanmugam, et al. "Carnosic Acid: a Potent Chemopreventive Agent Against Oral Carcinogenesis." Chemico-biological Interactions, vol. 188, no. 3, 2010, pp. 616-22.
Manoharan S, Vasanthaselvan M, Silvan S, et al. Carnosic acid: a potent chemopreventive agent against oral carcinogenesis. Chem Biol Interact. 2010;188(3):616-22.
Manoharan, S., Vasanthaselvan, M., Silvan, S., Baskaran, N., Kumar Singh, A., & Vinoth Kumar, V. (2010). Carnosic acid: a potent chemopreventive agent against oral carcinogenesis. Chemico-biological Interactions, 188(3), 616-22. https://doi.org/10.1016/j.cbi.2010.08.009
Manoharan S, et al. Carnosic Acid: a Potent Chemopreventive Agent Against Oral Carcinogenesis. Chem Biol Interact. 2010 Dec 5;188(3):616-22. PubMed PMID: 20816777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carnosic acid: a potent chemopreventive agent against oral carcinogenesis. AU - Manoharan,Shanmugam, AU - Vasanthaselvan,Muthamizhselvan, AU - Silvan,Simon, AU - Baskaran,Nagarethinam, AU - Kumar Singh,Arjun, AU - Vinoth Kumar,Veerasamy, Y1 - 2010/09/22/ PY - 2010/08/06/received PY - 2010/08/26/revised PY - 2010/08/27/accepted PY - 2010/9/7/entrez PY - 2010/9/8/pubmed PY - 2010/12/22/medline SP - 616 EP - 22 JF - Chemico-biological interactions JO - Chem Biol Interact VL - 188 IS - 3 N2 - The present study was aimed to investigate the chemopreventive potential of carnosic acid in 7,12-dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis. The chemopreventive potential was assessed by analyzing the tumor incidence, tumor volume and burden as well as by measuring the status of lipid peroxidation, non-enzymatic and enzymatic antioxidants and phase I and phase II detoxification enzymes. Oral squamous cell carcinoma was developed in the buccal pouch of golden Syrian hamsters by painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks. In the present study, 100% tumor formation was observed in hamsters treated with DMBA alone. Also, the status of lipid peroxidation, antioxidants and phase I and phase II detoxification enzymes were significantly altered during DMBA-induced oral carcinogenesis. Oral administration of carnosic acid at a dose of 10mg/kg body weight/day to DMBA-treated animals completely prevented the tumor formation in the hamsters' buccal pouches. Also, carnosic acid exerted potent anti-lipid peroxidative function and stimulated the detoxification cascade during DMBA-induced hamster buccal pouch carcinogenesis. The results of the present study suggest that the chemopreventive potential of carnosic acid is probably due to its anti-lipid peroxidative potential and modulating effect on carcinogen detoxification enzymes during DMBA-induced oral carcinogenesis. SN - 1872-7786 UR - https://www.unboundmedicine.com/medline/citation/20816777/Carnosic_acid:_a_potent_chemopreventive_agent_against_oral_carcinogenesis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(10)00529-6 DB - PRIME DP - Unbound Medicine ER -