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Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors.
Behav Brain Res 2011; 216(1):477-80BB

Abstract

The aim of the present study is to examine the relationship between preference for HFD and 2-arachidonoylglycerol (2-AG), endogenous cannabinoid. The 3-day HFD intake induced preference for HFD, which was suppressed by CB1 antagonist, O-2050. Moreover, hypothalamic 2-AG was increased after 3-day HFD intake. Our results show that preference for HFD is induced by activation of CB1 receptors via an increment of 2-AG in hypothalamus.

Authors+Show Affiliations

Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20817042

Citation

Higuchi, Sei, et al. "Increment of Hypothalamic 2-arachidonoylglycerol Induces the Preference for a High-fat Diet Via Activation of Cannabinoid 1 Receptors." Behavioural Brain Research, vol. 216, no. 1, 2011, pp. 477-80.
Higuchi S, Ohji M, Araki M, et al. Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors. Behav Brain Res. 2011;216(1):477-80.
Higuchi, S., Ohji, M., Araki, M., Furuta, R., Katsuki, M., Yamaguchi, R., ... Fujiwara, M. (2011). Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors. Behavioural Brain Research, 216(1), pp. 477-80. doi:10.1016/j.bbr.2010.08.042.
Higuchi S, et al. Increment of Hypothalamic 2-arachidonoylglycerol Induces the Preference for a High-fat Diet Via Activation of Cannabinoid 1 Receptors. Behav Brain Res. 2011 Jan 1;216(1):477-80. PubMed PMID: 20817042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors. AU - Higuchi,Sei, AU - Ohji,Makiko, AU - Araki,Maiko, AU - Furuta,Riyo, AU - Katsuki,Mai, AU - Yamaguchi,Ryuji, AU - Akitake,Yoshiharu, AU - Matsuyama,Kiyoshi, AU - Irie,Keiichi, AU - Mishima,Kenji, AU - Mishima,Kenichi, AU - Iwasaki,Katsunori, AU - Fujiwara,Michihiro, Y1 - 2010/09/09/ PY - 2010/07/05/received PY - 2010/08/26/revised PY - 2010/08/26/accepted PY - 2010/9/7/entrez PY - 2010/9/8/pubmed PY - 2011/2/22/medline SP - 477 EP - 80 JF - Behavioural brain research JO - Behav. Brain Res. VL - 216 IS - 1 N2 - The aim of the present study is to examine the relationship between preference for HFD and 2-arachidonoylglycerol (2-AG), endogenous cannabinoid. The 3-day HFD intake induced preference for HFD, which was suppressed by CB1 antagonist, O-2050. Moreover, hypothalamic 2-AG was increased after 3-day HFD intake. Our results show that preference for HFD is induced by activation of CB1 receptors via an increment of 2-AG in hypothalamus. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/20817042/abstract/Increment_of_hypothalamic_2_arachidonoylglycerol_induces_the_preference_for_a_high_fat_diet_via_activation_of_cannabinoid_1_receptors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(10)00614-5 DB - PRIME DP - Unbound Medicine ER -