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Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors.

Abstract

The aim of the present study is to examine the relationship between preference for HFD and 2-arachidonoylglycerol (2-AG), endogenous cannabinoid. The 3-day HFD intake induced preference for HFD, which was suppressed by CB1 antagonist, O-2050. Moreover, hypothalamic 2-AG was increased after 3-day HFD intake. Our results show that preference for HFD is induced by activation of CB1 receptors via an increment of 2-AG in hypothalamus.

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  • Authors+Show Affiliations

    ,

    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.

    , , , , , , , , , , ,

    Source

    Behavioural brain research 216:1 2011 Jan 01 pg 477-80

    MeSH

    Animals
    Arachidonic Acids
    Dietary Fats
    Dronabinol
    Eating
    Endocannabinoids
    Food Preferences
    Glycerides
    Hypothalamus
    Male
    Mice
    Mice, Inbred ICR
    Pyrans
    Receptor, Cannabinoid, CB1

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20817042

    Citation

    * When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Increment of hypothalamic 2-arachidonoylglycerol induces the preference for a high-fat diet via activation of cannabinoid 1 receptors. AU - Higuchi,Sei, AU - Ohji,Makiko, AU - Araki,Maiko, AU - Furuta,Riyo, AU - Katsuki,Mai, AU - Yamaguchi,Ryuji, AU - Akitake,Yoshiharu, AU - Matsuyama,Kiyoshi, AU - Irie,Keiichi, AU - Mishima,Kenji, AU - Mishima,Kenichi, AU - Iwasaki,Katsunori, AU - Fujiwara,Michihiro, Y1 - 2010/09/09/ PY - 2010/07/05/received PY - 2010/08/26/revised PY - 2010/08/26/accepted PY - 2010/9/7/entrez PY - 2010/9/8/pubmed PY - 2011/2/22/medline SP - 477 EP - 80 JF - Behavioural brain research JO - Behav. Brain Res. VL - 216 IS - 1 N2 - The aim of the present study is to examine the relationship between preference for HFD and 2-arachidonoylglycerol (2-AG), endogenous cannabinoid. The 3-day HFD intake induced preference for HFD, which was suppressed by CB1 antagonist, O-2050. Moreover, hypothalamic 2-AG was increased after 3-day HFD intake. Our results show that preference for HFD is induced by activation of CB1 receptors via an increment of 2-AG in hypothalamus. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/20817042/abstract/Increment_of_hypothalamic_2_arachidonoylglycerol_induces_the_preference_for_a_high_fat_diet_via_activation_of_cannabinoid_1_receptors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(10)00614-5 DB - PRIME DP - Unbound Medicine ER -