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Laserlight cues for gait freezing in Parkinson's disease: an open-label study.
Parkinsonism Relat Disord. 2011 May; 17(4):240-5.PR

Abstract

Freezing of gait (FOG) and falls are major sources of disability for Parkinson's disease (PD) patients, and show limited responsiveness to medications. We assessed the efficacy of visual cues for overcoming FOG in an open-label study of 26 patients with PD. The change in the frequency of falls was a secondary outcome measure. Subjects underwent a 1-2 month baseline period of use of a cane or walker without visual cues, followed by 1 month using the same device with the laserlight visual cue. The laserlight visual cue was associated with a modest but significant mean reduction in FOG Questionnaire (FOGQ) scores of 1.25 ± 0.48 (p = 0.0152, two-tailed paired t-test), representing a 6.6% improvement compared to the mean baseline FOGQ scores of 18.8. The mean reduction in fall frequency was 39.5 ± 9.3% with the laserlight visual cue among subjects experiencing at least one fall during the baseline and subsequent study periods (p = 0.002; two-tailed one-sample t-test with hypothesized mean of 0). Though some individual subjects may have benefited, the overall mean performance on the timed gait test (TGT) across all subjects did not significantly change. However, among the 4 subjects who underwent repeated testing of the TGT, one showed a 50% mean improvement in TGT performance with the laserlight visual cue (p = 0.005; two-tailed paired t-test). This open-label study provides evidence for modest efficacy of a laserlight visual cue in overcoming FOG and reducing falls in PD patients.

Authors+Show Affiliations

Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. donovask@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20817535

Citation

Donovan, S, et al. "Laserlight Cues for Gait Freezing in Parkinson's Disease: an Open-label Study." Parkinsonism & Related Disorders, vol. 17, no. 4, 2011, pp. 240-5.
Donovan S, Lim C, Diaz N, et al. Laserlight cues for gait freezing in Parkinson's disease: an open-label study. Parkinsonism Relat Disord. 2011;17(4):240-5.
Donovan, S., Lim, C., Diaz, N., Browner, N., Rose, P., Sudarsky, L. R., Tarsy, D., Fahn, S., & Simon, D. K. (2011). Laserlight cues for gait freezing in Parkinson's disease: an open-label study. Parkinsonism & Related Disorders, 17(4), 240-5. https://doi.org/10.1016/j.parkreldis.2010.08.010
Donovan S, et al. Laserlight Cues for Gait Freezing in Parkinson's Disease: an Open-label Study. Parkinsonism Relat Disord. 2011;17(4):240-5. PubMed PMID: 20817535.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Laserlight cues for gait freezing in Parkinson's disease: an open-label study. AU - Donovan,S, AU - Lim,C, AU - Diaz,N, AU - Browner,N, AU - Rose,P, AU - Sudarsky,L R, AU - Tarsy,D, AU - Fahn,S, AU - Simon,D K, Y1 - 2010/09/03/ PY - 2010/04/04/received PY - 2010/06/07/revised PY - 2010/08/06/accepted PY - 2010/9/7/entrez PY - 2010/9/8/pubmed PY - 2011/10/11/medline SP - 240 EP - 5 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 17 IS - 4 N2 - Freezing of gait (FOG) and falls are major sources of disability for Parkinson's disease (PD) patients, and show limited responsiveness to medications. We assessed the efficacy of visual cues for overcoming FOG in an open-label study of 26 patients with PD. The change in the frequency of falls was a secondary outcome measure. Subjects underwent a 1-2 month baseline period of use of a cane or walker without visual cues, followed by 1 month using the same device with the laserlight visual cue. The laserlight visual cue was associated with a modest but significant mean reduction in FOG Questionnaire (FOGQ) scores of 1.25 ± 0.48 (p = 0.0152, two-tailed paired t-test), representing a 6.6% improvement compared to the mean baseline FOGQ scores of 18.8. The mean reduction in fall frequency was 39.5 ± 9.3% with the laserlight visual cue among subjects experiencing at least one fall during the baseline and subsequent study periods (p = 0.002; two-tailed one-sample t-test with hypothesized mean of 0). Though some individual subjects may have benefited, the overall mean performance on the timed gait test (TGT) across all subjects did not significantly change. However, among the 4 subjects who underwent repeated testing of the TGT, one showed a 50% mean improvement in TGT performance with the laserlight visual cue (p = 0.005; two-tailed paired t-test). This open-label study provides evidence for modest efficacy of a laserlight visual cue in overcoming FOG and reducing falls in PD patients. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/20817535/Laserlight_cues_for_gait_freezing_in_Parkinson's_disease:_an_open_label_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(10)00208-7 DB - PRIME DP - Unbound Medicine ER -