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Biometric predictive models for the evaluation of olfactory recovery after endoscopic sinus surgery in patients with nasal polyposis.
Am J Rhinol Allergy 2010 Jul-Aug; 24(4):276-80AJ

Abstract

BACKGROUND

Determination of predictive factors and specific values of olfactory function after endoscopic sinus surgery (ESS) using objective diagnostic methods may support consultation of respective patients. This study was designed to assess the longitudinal olfactory functional outcome after ESS in patients with severe chronic rhinosinusitis (CRS) with nasal polyposis, to evaluate associated clinical factors and to provide statistical models for prediction of olfactory recovery.

METHODS

One hundred sixteen patients with nasal polyposis refractory to medical treatment underwent ESS. Olfactory testing was performed preoperatively and 1, 3, and 6 months after surgery using "Sniffin' Sticks" (Burghardt, Wedel, Germany). Using multivariate linear and logistic regression analysis, statistical models were generated to predict (i) the 6th-month composite threshold-discrimination-identification (TDI) score and (ii) the probability of attaining normal olfaction at 6 months.

RESULTS

A significant stepwise increment of all olfactory function indices was found over time. Factors influencing final olfactory recovery were patients' age, duration of olfactory deficit, previous paranasal sinus surgery, and aspirin-exacerbated respiratory disease. The first model explained 70% of the observed variation in postoperative TDI scores. The second model correctly classified 76% of the patients.

CONCLUSION

A significant progressive improvement of olfaction for at least 6 months was observed after ESS. The statistical models developed may be useful for consultation of ESS candidates in clinical practice.

Authors+Show Affiliations

Department of Otolaryngology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20819466

Citation

Katotomichelakis, Michael, et al. "Biometric Predictive Models for the Evaluation of Olfactory Recovery After Endoscopic Sinus Surgery in Patients With Nasal Polyposis." American Journal of Rhinology & Allergy, vol. 24, no. 4, 2010, pp. 276-80.
Katotomichelakis M, Gouveris H, Tripsianis G, et al. Biometric predictive models for the evaluation of olfactory recovery after endoscopic sinus surgery in patients with nasal polyposis. Am J Rhinol Allergy. 2010;24(4):276-80.
Katotomichelakis, M., Gouveris, H., Tripsianis, G., Simopoulou, M., Papathanassiou, J., & Danielides, V. (2010). Biometric predictive models for the evaluation of olfactory recovery after endoscopic sinus surgery in patients with nasal polyposis. American Journal of Rhinology & Allergy, 24(4), pp. 276-80. doi:10.2500/ajra.2010.24.3476.
Katotomichelakis M, et al. Biometric Predictive Models for the Evaluation of Olfactory Recovery After Endoscopic Sinus Surgery in Patients With Nasal Polyposis. Am J Rhinol Allergy. 2010;24(4):276-80. PubMed PMID: 20819466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biometric predictive models for the evaluation of olfactory recovery after endoscopic sinus surgery in patients with nasal polyposis. AU - Katotomichelakis,Michael, AU - Gouveris,Haralampos, AU - Tripsianis,Gregory, AU - Simopoulou,Maria, AU - Papathanassiou,Jannis, AU - Danielides,Vassilios, PY - 2010/9/8/entrez PY - 2010/9/8/pubmed PY - 2011/3/16/medline SP - 276 EP - 80 JF - American journal of rhinology & allergy JO - Am J Rhinol Allergy VL - 24 IS - 4 N2 - BACKGROUND: Determination of predictive factors and specific values of olfactory function after endoscopic sinus surgery (ESS) using objective diagnostic methods may support consultation of respective patients. This study was designed to assess the longitudinal olfactory functional outcome after ESS in patients with severe chronic rhinosinusitis (CRS) with nasal polyposis, to evaluate associated clinical factors and to provide statistical models for prediction of olfactory recovery. METHODS: One hundred sixteen patients with nasal polyposis refractory to medical treatment underwent ESS. Olfactory testing was performed preoperatively and 1, 3, and 6 months after surgery using "Sniffin' Sticks" (Burghardt, Wedel, Germany). Using multivariate linear and logistic regression analysis, statistical models were generated to predict (i) the 6th-month composite threshold-discrimination-identification (TDI) score and (ii) the probability of attaining normal olfaction at 6 months. RESULTS: A significant stepwise increment of all olfactory function indices was found over time. Factors influencing final olfactory recovery were patients' age, duration of olfactory deficit, previous paranasal sinus surgery, and aspirin-exacerbated respiratory disease. The first model explained 70% of the observed variation in postoperative TDI scores. The second model correctly classified 76% of the patients. CONCLUSION: A significant progressive improvement of olfaction for at least 6 months was observed after ESS. The statistical models developed may be useful for consultation of ESS candidates in clinical practice. SN - 1945-8932 UR - https://www.unboundmedicine.com/medline/citation/20819466/Biometric_predictive_models_for_the_evaluation_of_olfactory_recovery_after_endoscopic_sinus_surgery_in_patients_with_nasal_polyposis_ L2 - http://journals.sagepub.com/doi/full/10.2500/ajra.2010.24.3476?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -