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Restless legs syndrome as a possible predictor for psychiatric disorders in parents of children with ADHD.
Eur Arch Psychiatry Clin Neurosci 2011; 261(4):285-91EA

Abstract

Attention-deficit hyperactivity disorder (ADHD) is a common disorder with estimated prevalence of 5% in children and 3.4% in adults. Psychiatric disorders are a frequent concomitant feature. Restless legs syndrome (RLS) may mimic the symptoms of ADHD. The aim of the study is to evaluate whether the presence of RLS predicts occurrence of psychiatric disorders in parents of children with ADHD. Thirty-seven parents of 26 children with ADHD were examined for RLS and for lifetime prevalence rates of psychiatric disorders and personality disorders based on the Structured Clinical Interview for DSM-IV Diagnoses (SCID). Prevalence rates in parents were 29.7% for RLS, 67.6% for Axis I and 40.5% for Axis II disorders. Mothers revealed higher rates for depression, anxiety disorders and ADHD than fathers, whereas personality disorders occurred at higher rates in fathers. The presence of RLS predicted a diagnosis of ADHD (odds ratio (OR) 21.9), agoraphobia (OR = 20.4) and any anxiety disorder (OR = 8.5). Although limited by the small sample size, we found evidence for increased rates of cluster B personality disorders (OR = 59.3) in parents with RLS. All parents of the latter group (100%) reported a positive family history of psychiatric disorders which was not the case in parents without RLS (69.2%) excluding the index children with ADHD. RLS seems to indicate increased vulnerability for psychiatric disorders, i.e., ADHD and anxiety disorders, in a subgroup of parents from ADHD children. Synaptic dysfunction affecting dopaminergic transmission among other transmitter systems may be a common final pathway related to the phenotypic spectrum of ADHD.

Authors+Show Affiliations

Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, Luebeck, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20820796

Citation

Steinlechner, Susanne, et al. "Restless Legs Syndrome as a Possible Predictor for Psychiatric Disorders in Parents of Children With ADHD." European Archives of Psychiatry and Clinical Neuroscience, vol. 261, no. 4, 2011, pp. 285-91.
Steinlechner S, Brüggemann N, Sobottka V, et al. Restless legs syndrome as a possible predictor for psychiatric disorders in parents of children with ADHD. Eur Arch Psychiatry Clin Neurosci. 2011;261(4):285-91.
Steinlechner, S., Brüggemann, N., Sobottka, V., Benthien, A., Behn, B., Klein, C., ... Lencer, R. (2011). Restless legs syndrome as a possible predictor for psychiatric disorders in parents of children with ADHD. European Archives of Psychiatry and Clinical Neuroscience, 261(4), pp. 285-91. doi:10.1007/s00406-010-0140-z.
Steinlechner S, et al. Restless Legs Syndrome as a Possible Predictor for Psychiatric Disorders in Parents of Children With ADHD. Eur Arch Psychiatry Clin Neurosci. 2011;261(4):285-91. PubMed PMID: 20820796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Restless legs syndrome as a possible predictor for psychiatric disorders in parents of children with ADHD. AU - Steinlechner,Susanne, AU - Brüggemann,Norbert, AU - Sobottka,Vera, AU - Benthien,Alexander, AU - Behn,Birte, AU - Klein,Christine, AU - Schmid,Gabriele, AU - Lencer,Rebekka, Y1 - 2010/09/04/ PY - 2009/11/23/received PY - 2010/08/17/accepted PY - 2010/9/8/entrez PY - 2010/9/8/pubmed PY - 2011/10/15/medline SP - 285 EP - 91 JF - European archives of psychiatry and clinical neuroscience JO - Eur Arch Psychiatry Clin Neurosci VL - 261 IS - 4 N2 - Attention-deficit hyperactivity disorder (ADHD) is a common disorder with estimated prevalence of 5% in children and 3.4% in adults. Psychiatric disorders are a frequent concomitant feature. Restless legs syndrome (RLS) may mimic the symptoms of ADHD. The aim of the study is to evaluate whether the presence of RLS predicts occurrence of psychiatric disorders in parents of children with ADHD. Thirty-seven parents of 26 children with ADHD were examined for RLS and for lifetime prevalence rates of psychiatric disorders and personality disorders based on the Structured Clinical Interview for DSM-IV Diagnoses (SCID). Prevalence rates in parents were 29.7% for RLS, 67.6% for Axis I and 40.5% for Axis II disorders. Mothers revealed higher rates for depression, anxiety disorders and ADHD than fathers, whereas personality disorders occurred at higher rates in fathers. The presence of RLS predicted a diagnosis of ADHD (odds ratio (OR) 21.9), agoraphobia (OR = 20.4) and any anxiety disorder (OR = 8.5). Although limited by the small sample size, we found evidence for increased rates of cluster B personality disorders (OR = 59.3) in parents with RLS. All parents of the latter group (100%) reported a positive family history of psychiatric disorders which was not the case in parents without RLS (69.2%) excluding the index children with ADHD. RLS seems to indicate increased vulnerability for psychiatric disorders, i.e., ADHD and anxiety disorders, in a subgroup of parents from ADHD children. Synaptic dysfunction affecting dopaminergic transmission among other transmitter systems may be a common final pathway related to the phenotypic spectrum of ADHD. SN - 1433-8491 UR - https://www.unboundmedicine.com/medline/citation/20820796/Restless_legs_syndrome_as_a_possible_predictor_for_psychiatric_disorders_in_parents_of_children_with_ADHD_ L2 - https://dx.doi.org/10.1007/s00406-010-0140-z DB - PRIME DP - Unbound Medicine ER -