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Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer: a pooled analysis of prospective cohort studies.
Cancer Causes Control 2010; 21(11):1745-57CC

Abstract

OBJECTIVE

To evaluate the associations between intakes of vitamins A, C, and E and risk of colon cancer.

METHODS

Using the primary data from 13 cohort studies, we estimated study- and sex-specific relative risks (RR) with Cox proportional hazards models and subsequently pooled RRs using a random effects model.

RESULTS

Among 676,141 men and women, 5,454 colon cancer cases were identified (7-20 years of follow-up across studies). Vitamin A, C, and E intakes from food only were not associated with colon cancer risk. For intakes from food and supplements (total), the pooled multivariate RRs (95% CI) were 0.88 (0.76-1.02, >4,000 vs. ≤ 1,000 μg/day) for vitamin A, 0.81 (0.71-0.92, >600 vs. ≤ 100 mg/day) for vitamin C, and 0.78 (0.66-0.92, > 200 vs. ≤ 6 mg/day) for vitamin E. Adjustment for total folate intake attenuated these associations, but the inverse associations with vitamins C and E remained significant. Multivitamin use was significantly inversely associated with colon cancer risk (RR = 0.88, 95% CI: 0.81-0.96).

CONCLUSIONS

Modest inverse associations with vitamin C and E intakes may be due to high correlations with folate intake, which had a similar inverse association with colon cancer. An inverse association with multivitamin use, a major source of folate and other vitamins, deserves further study.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20820901

Citation

Park, Yikyung, et al. "Intakes of Vitamins A, C, and E and Use of Multiple Vitamin Supplements and Risk of Colon Cancer: a Pooled Analysis of Prospective Cohort Studies." Cancer Causes & Control : CCC, vol. 21, no. 11, 2010, pp. 1745-57.
Park Y, Spiegelman D, Hunter DJ, et al. Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer: a pooled analysis of prospective cohort studies. Cancer Causes Control. 2010;21(11):1745-57.
Park, Y., Spiegelman, D., Hunter, D. J., Albanes, D., Bergkvist, L., Buring, J. E., ... Smith-Warner, S. A. (2010). Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer: a pooled analysis of prospective cohort studies. Cancer Causes & Control : CCC, 21(11), pp. 1745-57. doi:10.1007/s10552-010-9549-y.
Park Y, et al. Intakes of Vitamins A, C, and E and Use of Multiple Vitamin Supplements and Risk of Colon Cancer: a Pooled Analysis of Prospective Cohort Studies. Cancer Causes Control. 2010;21(11):1745-57. PubMed PMID: 20820901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer: a pooled analysis of prospective cohort studies. AU - Park,Yikyung, AU - Spiegelman,Donna, AU - Hunter,David J, AU - Albanes,Demetrius, AU - Bergkvist,Leif, AU - Buring,Julie E, AU - Freudenheim,Jo L, AU - Giovannucci,Edward, AU - Goldbohm,R Alexandra, AU - Harnack,Lisa, AU - Kato,Ikuko, AU - Krogh,Vittorio, AU - Leitzmann,Michael F, AU - Limburg,Paul J, AU - Marshall,James R, AU - McCullough,Marjorie L, AU - Miller,Anthony B, AU - Rohan,Thomas E, AU - Schatzkin,Arthur, AU - Shore,Roy, AU - Sieri,Sabina, AU - Stampfer,Meir J, AU - Virtamo,Jarmo, AU - Weijenberg,Matty, AU - Willett,Walter C, AU - Wolk,Alicja, AU - Zhang,Shumin M, AU - Smith-Warner,Stephanie A, Y1 - 2010/09/05/ PY - 2009/09/03/received PY - 2010/03/18/accepted PY - 2010/9/8/entrez PY - 2010/9/8/pubmed PY - 2011/3/2/medline SP - 1745 EP - 57 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 21 IS - 11 N2 - OBJECTIVE: To evaluate the associations between intakes of vitamins A, C, and E and risk of colon cancer. METHODS: Using the primary data from 13 cohort studies, we estimated study- and sex-specific relative risks (RR) with Cox proportional hazards models and subsequently pooled RRs using a random effects model. RESULTS: Among 676,141 men and women, 5,454 colon cancer cases were identified (7-20 years of follow-up across studies). Vitamin A, C, and E intakes from food only were not associated with colon cancer risk. For intakes from food and supplements (total), the pooled multivariate RRs (95% CI) were 0.88 (0.76-1.02, >4,000 vs. ≤ 1,000 μg/day) for vitamin A, 0.81 (0.71-0.92, >600 vs. ≤ 100 mg/day) for vitamin C, and 0.78 (0.66-0.92, > 200 vs. ≤ 6 mg/day) for vitamin E. Adjustment for total folate intake attenuated these associations, but the inverse associations with vitamins C and E remained significant. Multivitamin use was significantly inversely associated with colon cancer risk (RR = 0.88, 95% CI: 0.81-0.96). CONCLUSIONS: Modest inverse associations with vitamin C and E intakes may be due to high correlations with folate intake, which had a similar inverse association with colon cancer. An inverse association with multivitamin use, a major source of folate and other vitamins, deserves further study. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/20820901/Intakes_of_vitamins_A_C_and_E_and_use_of_multiple_vitamin_supplements_and_risk_of_colon_cancer:_a_pooled_analysis_of_prospective_cohort_studies_ L2 - https://doi.org/10.1007/s10552-010-9549-y DB - PRIME DP - Unbound Medicine ER -