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Multifocal visual evoked potential recordings in compressive optic neuropathy secondary to pituitary adenoma.
Doc Ophthalmol. 2010 Dec; 121(3):197-204.DO

Abstract

To investigate the effect of pituitary adenoma compressing the optic chiasm on multifocal visual evoked potential (mfVEP) responses and to compare these responses with visual field defects seen on static automated perimetry (SAP). Eight eyes of four subjects (median age, 41.50 years; interquartile range, 33-51 years) who were diagnosed with pituitary adenoma on magnetic resonance imaging (MRI) and seen to have a bitemporal visual field defect on standard automated perimetry (SAP), and twelve age-matched normal subjects (median age, 47.00 years; interquartile range, 34.75-51.75 years) were subjected to multifocal visual evoked potential (mfVEP) testing. The monocular latencies and monocular amplitudes of each sector of cases were compared with the responses of normative database. The topography of the mfVEP response was compared with corresponding field defect as seen in total deviation threshold on SAP to allow a comparison with conventional subjective perimetry. The mfVEP amplitudes were reduced in the areas with visual field defect on SAP. In 6 out of 8 eyes, locations with preserved amplitudes and no visual defects showed prolonged latency. A prolonged median latency of 9.17 ms (interquartile range, 3.44-17.69 ms) in cases was seen when compared to the median latency of 1.67 ms (interquartile range, 0.94-4.17 ms) in age-matched controls with P value of 0.054. Chiasmal compression due to pituitary adenoma causes the reduction of amplitudes and prolongation of latencies of the mfVEP response. The mfVEP can be used to assess objectively the topography of the visual field in compressive optic neuropathy secondary to pituitary adenomas. It can be used in assessing the subjects whose visual field report is unreliable and prolonged median latency can be an early sign of the disease.

Authors+Show Affiliations

Elite School of Optometry, Unit of Medical Research Foundation, Sankara Nethralaya, 18, College Road, Chennai, 600006, India. manjujayaselvi87@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20821036

Citation

Jayaraman, Manju, et al. "Multifocal Visual Evoked Potential Recordings in Compressive Optic Neuropathy Secondary to Pituitary Adenoma." Documenta Ophthalmologica. Advances in Ophthalmology, vol. 121, no. 3, 2010, pp. 197-204.
Jayaraman M, Ambika S, Gandhi RA, et al. Multifocal visual evoked potential recordings in compressive optic neuropathy secondary to pituitary adenoma. Doc Ophthalmol. 2010;121(3):197-204.
Jayaraman, M., Ambika, S., Gandhi, R. A., Bassi, S. R., Ravi, P., & Sen, P. (2010). Multifocal visual evoked potential recordings in compressive optic neuropathy secondary to pituitary adenoma. Documenta Ophthalmologica. Advances in Ophthalmology, 121(3), 197-204. https://doi.org/10.1007/s10633-010-9246-x
Jayaraman M, et al. Multifocal Visual Evoked Potential Recordings in Compressive Optic Neuropathy Secondary to Pituitary Adenoma. Doc Ophthalmol. 2010;121(3):197-204. PubMed PMID: 20821036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multifocal visual evoked potential recordings in compressive optic neuropathy secondary to pituitary adenoma. AU - Jayaraman,Manju, AU - Ambika,S, AU - Gandhi,Rashmin Anilkumar, AU - Bassi,Shikha Rajesh, AU - Ravi,Priya, AU - Sen,Parveen, Y1 - 2010/09/04/ PY - 2010/04/13/received PY - 2010/08/17/accepted PY - 2010/9/8/entrez PY - 2010/9/8/pubmed PY - 2011/2/22/medline SP - 197 EP - 204 JF - Documenta ophthalmologica. Advances in ophthalmology JO - Doc Ophthalmol VL - 121 IS - 3 N2 - To investigate the effect of pituitary adenoma compressing the optic chiasm on multifocal visual evoked potential (mfVEP) responses and to compare these responses with visual field defects seen on static automated perimetry (SAP). Eight eyes of four subjects (median age, 41.50 years; interquartile range, 33-51 years) who were diagnosed with pituitary adenoma on magnetic resonance imaging (MRI) and seen to have a bitemporal visual field defect on standard automated perimetry (SAP), and twelve age-matched normal subjects (median age, 47.00 years; interquartile range, 34.75-51.75 years) were subjected to multifocal visual evoked potential (mfVEP) testing. The monocular latencies and monocular amplitudes of each sector of cases were compared with the responses of normative database. The topography of the mfVEP response was compared with corresponding field defect as seen in total deviation threshold on SAP to allow a comparison with conventional subjective perimetry. The mfVEP amplitudes were reduced in the areas with visual field defect on SAP. In 6 out of 8 eyes, locations with preserved amplitudes and no visual defects showed prolonged latency. A prolonged median latency of 9.17 ms (interquartile range, 3.44-17.69 ms) in cases was seen when compared to the median latency of 1.67 ms (interquartile range, 0.94-4.17 ms) in age-matched controls with P value of 0.054. Chiasmal compression due to pituitary adenoma causes the reduction of amplitudes and prolongation of latencies of the mfVEP response. The mfVEP can be used to assess objectively the topography of the visual field in compressive optic neuropathy secondary to pituitary adenomas. It can be used in assessing the subjects whose visual field report is unreliable and prolonged median latency can be an early sign of the disease. SN - 1573-2622 UR - https://www.unboundmedicine.com/medline/citation/20821036/Multifocal_visual_evoked_potential_recordings_in_compressive_optic_neuropathy_secondary_to_pituitary_adenoma_ DB - PRIME DP - Unbound Medicine ER -