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Triterpenoid saponins from Ardisia gigantifolia.
Chem Pharm Bull (Tokyo). 2010 Sep; 58(9):1248-51.CP

Abstract

Four new triterpenoid saponins (1-4) were isolated from the rhizome of Ardisia gigantifolia STAPF. The structures of new saponins were established as 3beta-o-alpha-L-rhamnopyranosyl-(1-->3)-[beta-D-xylopyranosyl-(1-->2)]-beta-D-glucopyranosyl-(1-->4)-[beta-D-glucopyranosyl-(1-->2)]-alpha-L-arabinopyranosyl-16alpha-hydroxy-13,28-epoxy-oleanane (1), 3beta-o-alpha-L-rhamnopyranosyl-(1-->3)-[beta-D-xylopyranosyl-(1-->2)]-beta-D-glucopyranosyl-(1-->4)-[beta-D-glucopyrano-syl-(1-->2)]-alpha-L-arabinopyranosyl-16alpha-hydroxy-13,28-epoxy-30-acetoxy-oleanane (2), 3beta-o-alpha-L-rhamnopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->4)-beta-D-xylopyranosyl-(1-->2)]-beta-D-glucopyranosyl-(1-->4)-[beta-D-glucopyranosyl-(1-->2)]-alpha-L-arabinopyranosyl-16alpha-hydroxy-13,28-epoxy-oleanane (3) and 3beta-o-alpha-L-rhamnopyranosyl-(1-->3)-[beta-D-xylopyranosyl-(1-->2)]-beta-D-glucopyranosyl-(1-->4)-[beta-D-6-O-acetylglucopranosyl-(1-->2)]-alpha-L-arabinopyranosyl-16alpha-hydroxy-13,28-epoxy-oleanane (4) were isolated from Ardisia gigantifolia STAPF. Their structures were elucidated by means of (1)H- and (13)C-NMR spectroscopic studies, including 2D-NMR technique. The cytotoxic activities of saponins 1-4 are reported against three human cancer cell lines, namely, Hela human cervical carcinoma cells, EJ human bladder tumor cells, and BCG-823 human gastric carcinoma cells.

Authors+Show Affiliations

Department of Clinical Pharmacology, General Hospital of PLA, Beijing 100853, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20823610

Citation

Mu, Li-Hua, et al. "Triterpenoid Saponins From Ardisia Gigantifolia." Chemical & Pharmaceutical Bulletin, vol. 58, no. 9, 2010, pp. 1248-51.
Mu LH, Gong QQ, Zhao HX, et al. Triterpenoid saponins from Ardisia gigantifolia. Chem Pharm Bull (Tokyo). 2010;58(9):1248-51.
Mu, L. H., Gong, Q. Q., Zhao, H. X., & Liu, P. (2010). Triterpenoid saponins from Ardisia gigantifolia. Chemical & Pharmaceutical Bulletin, 58(9), 1248-51.
Mu LH, et al. Triterpenoid Saponins From Ardisia Gigantifolia. Chem Pharm Bull (Tokyo). 2010;58(9):1248-51. PubMed PMID: 20823610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triterpenoid saponins from Ardisia gigantifolia. AU - Mu,Li-Hua, AU - Gong,Qiang-Qiang, AU - Zhao,Hai-Xia, AU - Liu,Ping, PY - 2010/9/9/entrez PY - 2010/9/9/pubmed PY - 2011/1/14/medline SP - 1248 EP - 51 JF - Chemical & pharmaceutical bulletin JO - Chem Pharm Bull (Tokyo) VL - 58 IS - 9 N2 - Four new triterpenoid saponins (1-4) were isolated from the rhizome of Ardisia gigantifolia STAPF. The structures of new saponins were established as 3beta-o-alpha-L-rhamnopyranosyl-(1-->3)-[beta-D-xylopyranosyl-(1-->2)]-beta-D-glucopyranosyl-(1-->4)-[beta-D-glucopyranosyl-(1-->2)]-alpha-L-arabinopyranosyl-16alpha-hydroxy-13,28-epoxy-oleanane (1), 3beta-o-alpha-L-rhamnopyranosyl-(1-->3)-[beta-D-xylopyranosyl-(1-->2)]-beta-D-glucopyranosyl-(1-->4)-[beta-D-glucopyrano-syl-(1-->2)]-alpha-L-arabinopyranosyl-16alpha-hydroxy-13,28-epoxy-30-acetoxy-oleanane (2), 3beta-o-alpha-L-rhamnopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->4)-beta-D-xylopyranosyl-(1-->2)]-beta-D-glucopyranosyl-(1-->4)-[beta-D-glucopyranosyl-(1-->2)]-alpha-L-arabinopyranosyl-16alpha-hydroxy-13,28-epoxy-oleanane (3) and 3beta-o-alpha-L-rhamnopyranosyl-(1-->3)-[beta-D-xylopyranosyl-(1-->2)]-beta-D-glucopyranosyl-(1-->4)-[beta-D-6-O-acetylglucopranosyl-(1-->2)]-alpha-L-arabinopyranosyl-16alpha-hydroxy-13,28-epoxy-oleanane (4) were isolated from Ardisia gigantifolia STAPF. Their structures were elucidated by means of (1)H- and (13)C-NMR spectroscopic studies, including 2D-NMR technique. The cytotoxic activities of saponins 1-4 are reported against three human cancer cell lines, namely, Hela human cervical carcinoma cells, EJ human bladder tumor cells, and BCG-823 human gastric carcinoma cells. SN - 1347-5223 UR - https://www.unboundmedicine.com/medline/citation/20823610/Triterpenoid_saponins_from_Ardisia_gigantifolia_ L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/cpb/58.1248?from=PubMed DB - PRIME DP - Unbound Medicine ER -