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Cumulative cardiac toxicity of sodium stibogluconate and amphotericin B in treatment of kala-azar.
Pediatr Infect Dis J. 2011 Feb; 30(2):180-1.PI

Abstract

Kala-azar or visceral leishmaniasis is a disseminated protozoal infection caused by parasites of the genus Leishmania (Leishmania donovani in India). Conventional therapy for visceral leishmaniasis continues to be pentavalent antimony (sodium antimony gluconate [SAG]). Amphotericin B is widely used for SAG-unresponsive cases and sometimes even as a first-line drug, especially in endemic areas. With the conventional regimen of SAG, cardiac toxicity has been reported in 8% to 17% of cases with 5% to 7% of them having fatal toxicity. Cardiac toxicity is uncommon with amphotericin B with only few isolated reports. We report some patients with kala-azar in whom coadministration of SAG and amphotericin B led to arrhythmia and sudden death.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Maheshwari A
Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India. dranugulati@gmail.com
Seth A
No affiliation info available
Kaur S
No affiliation info available
Aneja S
No affiliation info available
Rath B
No affiliation info available
Basu S
No affiliation info available
Patel R
No affiliation info available
Dutta AK
No affiliation info available

MeSH

Amphotericin BAntimony Sodium GluconateAntiprotozoal AgentsArrhythmias, CardiacChildChild, PreschoolDrug Therapy, CombinationFatal OutcomeHumansIndiaLeishmania donovaniLeishmaniasis, VisceralMale

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

20823781

Citation

Maheshwari, Anu, et al. "Cumulative Cardiac Toxicity of Sodium Stibogluconate and Amphotericin B in Treatment of Kala-azar." The Pediatric Infectious Disease Journal, vol. 30, no. 2, 2011, pp. 180-1.
Maheshwari A, Seth A, Kaur S, et al. Cumulative cardiac toxicity of sodium stibogluconate and amphotericin B in treatment of kala-azar. Pediatr Infect Dis J. 2011;30(2):180-1.
Maheshwari, A., Seth, A., Kaur, S., Aneja, S., Rath, B., Basu, S., Patel, R., & Dutta, A. K. (2011). Cumulative cardiac toxicity of sodium stibogluconate and amphotericin B in treatment of kala-azar. The Pediatric Infectious Disease Journal, 30(2), 180-1. https://doi.org/10.1097/INF.0b013e3181f55843
Maheshwari A, et al. Cumulative Cardiac Toxicity of Sodium Stibogluconate and Amphotericin B in Treatment of Kala-azar. Pediatr Infect Dis J. 2011;30(2):180-1. PubMed PMID: 20823781.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cumulative cardiac toxicity of sodium stibogluconate and amphotericin B in treatment of kala-azar. AU - Maheshwari,Anu, AU - Seth,Anju, AU - Kaur,Satnam, AU - Aneja,Satinder, AU - Rath,Bimbadhar, AU - Basu,Srikanta, AU - Patel,Rakesh, AU - Dutta,Ashok Kumar, PY - 2010/9/9/entrez PY - 2010/9/9/pubmed PY - 2011/4/22/medline SP - 180 EP - 1 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 30 IS - 2 N2 - Kala-azar or visceral leishmaniasis is a disseminated protozoal infection caused by parasites of the genus Leishmania (Leishmania donovani in India). Conventional therapy for visceral leishmaniasis continues to be pentavalent antimony (sodium antimony gluconate [SAG]). Amphotericin B is widely used for SAG-unresponsive cases and sometimes even as a first-line drug, especially in endemic areas. With the conventional regimen of SAG, cardiac toxicity has been reported in 8% to 17% of cases with 5% to 7% of them having fatal toxicity. Cardiac toxicity is uncommon with amphotericin B with only few isolated reports. We report some patients with kala-azar in whom coadministration of SAG and amphotericin B led to arrhythmia and sudden death. SN - 1532-0987 UR - https://www.unboundmedicine.com/medline/citation/20823781/Cumulative_cardiac_toxicity_of_sodium_stibogluconate_and_amphotericin_B_in_treatment_of_kala_azar_ DB - PRIME DP - Unbound Medicine ER -