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High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile.
Eur J Clin Nutr. 2010 Dec; 64(12):1457-64.EJ

Abstract

BACKGROUND/OBJECTIVES

Low serum 25-hydroxyvitamin D (25(OH)D) concentrations are related to increased mortality. One possible explanation could be an association between serum 25(OH)D and serum lipids.

SUBJECTS/METHODS

The study was performed at the University of Tromsø, Northern Norway. In total, 8018 nonsmoking and 2087 smoking subjects were included in a cross-sectional study performed in 2008, and 1762 nonsmoking and 397 smoking subjects in a longitudinal study from 1994/1995 to 2008. Nonfasting serum 25(OH)D, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), LDL-C/HDL-C ratio and triacylglycerol (TAG) were measured.

RESULTS

After adjustment for gender, age, sample month and body mass index in the cross-sectional study, there was a significant increase in serum TC, HDL-C and LDL-C, and a significant decrease in serum LDL-C/HDL-C ratio and TAG across increasing serum 25(OH)D quartiles. For serum HDL-C and TAG in nonsmokers the differences between the means for the highest and lowest serum 25(OH)D quartiles were 6.0 and 18.5%, respectively. In the longitudinal study, an increase in serum 25(OH)D was associated with a significant decrease in serum TAG.

CONCLUSIONS

There is a cross-sectional association between serum 25(OH)D and serum lipids, and a longitudinal association over 14 years between serum 25(OH)D and TAG, which may contribute to explain the relation between low serum 25(OH)D concentrations and mortality.

Authors+Show Affiliations

Tromsø Endocrine Research Group, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway. rolf.jorde@unn.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20823896

Citation

Jorde, R, et al. "High Serum 25-hydroxyvitamin D Concentrations Are Associated With a Favorable Serum Lipid Profile." European Journal of Clinical Nutrition, vol. 64, no. 12, 2010, pp. 1457-64.
Jorde R, Figenschau Y, Hutchinson M, et al. High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile. Eur J Clin Nutr. 2010;64(12):1457-64.
Jorde, R., Figenschau, Y., Hutchinson, M., Emaus, N., & Grimnes, G. (2010). High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile. European Journal of Clinical Nutrition, 64(12), 1457-64. https://doi.org/10.1038/ejcn.2010.176
Jorde R, et al. High Serum 25-hydroxyvitamin D Concentrations Are Associated With a Favorable Serum Lipid Profile. Eur J Clin Nutr. 2010;64(12):1457-64. PubMed PMID: 20823896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile. AU - Jorde,R, AU - Figenschau,Y, AU - Hutchinson,M, AU - Emaus,N, AU - Grimnes,G, Y1 - 2010/09/08/ PY - 2010/9/9/entrez PY - 2010/9/9/pubmed PY - 2011/3/11/medline SP - 1457 EP - 64 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 64 IS - 12 N2 - BACKGROUND/OBJECTIVES: Low serum 25-hydroxyvitamin D (25(OH)D) concentrations are related to increased mortality. One possible explanation could be an association between serum 25(OH)D and serum lipids. SUBJECTS/METHODS: The study was performed at the University of Tromsø, Northern Norway. In total, 8018 nonsmoking and 2087 smoking subjects were included in a cross-sectional study performed in 2008, and 1762 nonsmoking and 397 smoking subjects in a longitudinal study from 1994/1995 to 2008. Nonfasting serum 25(OH)D, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), LDL-C/HDL-C ratio and triacylglycerol (TAG) were measured. RESULTS: After adjustment for gender, age, sample month and body mass index in the cross-sectional study, there was a significant increase in serum TC, HDL-C and LDL-C, and a significant decrease in serum LDL-C/HDL-C ratio and TAG across increasing serum 25(OH)D quartiles. For serum HDL-C and TAG in nonsmokers the differences between the means for the highest and lowest serum 25(OH)D quartiles were 6.0 and 18.5%, respectively. In the longitudinal study, an increase in serum 25(OH)D was associated with a significant decrease in serum TAG. CONCLUSIONS: There is a cross-sectional association between serum 25(OH)D and serum lipids, and a longitudinal association over 14 years between serum 25(OH)D and TAG, which may contribute to explain the relation between low serum 25(OH)D concentrations and mortality. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/20823896/High_serum_25_hydroxyvitamin_D_concentrations_are_associated_with_a_favorable_serum_lipid_profile_ L2 - https://doi.org/10.1038/ejcn.2010.176 DB - PRIME DP - Unbound Medicine ER -