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A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasthenoteratozoospermia.

Abstract

Male factor infertility is a multifactorial disorder that affects a significant percentage of infertile couples; however, many of them remained untreated. In recent years, considerable numbers of infertile men have sought 'herbal remedies' as an effective treatment. Among 'herbal remedies', saffron is recommended for male infertility in our community. The effect of saffron was evaluated compared with placebo for the treatment of idiopathic male factor infertility. The study included 260 infertile men with idiopathic oligoasthenoteratozoospermia (OAT) who were randomized to saffron 60 mg/day (130, group 1) or a similar regimen of placebo (130, group 2) for 26 weeks. The two groups were compared for changes in semen parameters and total seminal plasma antioxidant capacity. Saffron administration did not result in beneficial effects. At the end of the study no statistically significant improvements were observed in either group in any of the studied semen parameters (sperm density, morphology and motility) (all p = 0.1). At the end of the trial, patients in group 1 had a mean motility of 25.7 ± 2.4%, which was not statistically different from the mean of 24.9 ± 2.8% in the placebo group (p = 0.1). Normal sperm morphology was 18.7 ± 4.7% and 18.4 ± 4.3%, in groups 1 and 2, respectively (p = 0.1). Patients treated with saffron and placebo had a mean sperm density of 20.5 ± 4.6% and 21.4 ± 4.6% per mL, respectively (p = 0.1). Saffron administration did not improve total seminal plasma antioxidant capacity, compared with baseline (p = 0.1) and placebo subjects (p = 0.1). Based on Pearson correlations, each semen parameter did not correlate significantly with treatment duration, including sperm density (r = 0.146, p = 0.13), percent of motile sperm (r = 0.145, p = 0.15) and percent of sperm with normal morphology (r = 0.125, p = 0.30). Saffron does not statistically significantly improve semen parameters in infertile men with idiopathic OAT. If medical professionals want to prescribe herbal remedies for male infertility, previous rigorous scientific investigations, documenting their safety and efficacy are required.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Private Practice of Urology and Andrology, Tehran, Iran. safarinejad@urologist.md

    ,

    Source

    Phytotherapy research : PTR 25:4 2011 Apr pg 508-16

    MeSH

    Adult
    Antioxidants
    Crocus
    Double-Blind Method
    Humans
    Infertility, Male
    Karyotyping
    Male
    Placebos
    Prospective Studies
    Semen

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    20824894

    Citation

    Safarinejad, Mohammad Reza, et al. "A Prospective Double-blind Randomized Placebo-controlled Study of the Effect of Saffron (Crocus Sativus Linn.) On Semen Parameters and Seminal Plasma Antioxidant Capacity in Infertile Men With Idiopathic Oligoasthenoteratozoospermia." Phytotherapy Research : PTR, vol. 25, no. 4, 2011, pp. 508-16.
    Safarinejad MR, Shafiei N, Safarinejad S. A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasthenoteratozoospermia. Phytother Res. 2011;25(4):508-16.
    Safarinejad, M. R., Shafiei, N., & Safarinejad, S. (2011). A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasthenoteratozoospermia. Phytotherapy Research : PTR, 25(4), pp. 508-16. doi:10.1002/ptr.3294.
    Safarinejad MR, Shafiei N, Safarinejad S. A Prospective Double-blind Randomized Placebo-controlled Study of the Effect of Saffron (Crocus Sativus Linn.) On Semen Parameters and Seminal Plasma Antioxidant Capacity in Infertile Men With Idiopathic Oligoasthenoteratozoospermia. Phytother Res. 2011;25(4):508-16. PubMed PMID: 20824894.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasthenoteratozoospermia. AU - Safarinejad,Mohammad Reza, AU - Shafiei,Nayyer, AU - Safarinejad,Shiva, Y1 - 2010/09/07/ PY - 2010/02/25/received PY - 2010/07/23/revised PY - 2010/08/05/accepted PY - 2010/9/9/entrez PY - 2010/9/9/pubmed PY - 2011/7/6/medline SP - 508 EP - 16 JF - Phytotherapy research : PTR JO - Phytother Res VL - 25 IS - 4 N2 - Male factor infertility is a multifactorial disorder that affects a significant percentage of infertile couples; however, many of them remained untreated. In recent years, considerable numbers of infertile men have sought 'herbal remedies' as an effective treatment. Among 'herbal remedies', saffron is recommended for male infertility in our community. The effect of saffron was evaluated compared with placebo for the treatment of idiopathic male factor infertility. The study included 260 infertile men with idiopathic oligoasthenoteratozoospermia (OAT) who were randomized to saffron 60 mg/day (130, group 1) or a similar regimen of placebo (130, group 2) for 26 weeks. The two groups were compared for changes in semen parameters and total seminal plasma antioxidant capacity. Saffron administration did not result in beneficial effects. At the end of the study no statistically significant improvements were observed in either group in any of the studied semen parameters (sperm density, morphology and motility) (all p = 0.1). At the end of the trial, patients in group 1 had a mean motility of 25.7 ± 2.4%, which was not statistically different from the mean of 24.9 ± 2.8% in the placebo group (p = 0.1). Normal sperm morphology was 18.7 ± 4.7% and 18.4 ± 4.3%, in groups 1 and 2, respectively (p = 0.1). Patients treated with saffron and placebo had a mean sperm density of 20.5 ± 4.6% and 21.4 ± 4.6% per mL, respectively (p = 0.1). Saffron administration did not improve total seminal plasma antioxidant capacity, compared with baseline (p = 0.1) and placebo subjects (p = 0.1). Based on Pearson correlations, each semen parameter did not correlate significantly with treatment duration, including sperm density (r = 0.146, p = 0.13), percent of motile sperm (r = 0.145, p = 0.15) and percent of sperm with normal morphology (r = 0.125, p = 0.30). Saffron does not statistically significantly improve semen parameters in infertile men with idiopathic OAT. If medical professionals want to prescribe herbal remedies for male infertility, previous rigorous scientific investigations, documenting their safety and efficacy are required. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/20824894/A_prospective_double_blind_randomized_placebo_controlled_study_of_the_effect_of_saffron__Crocus_sativus_Linn___on_semen_parameters_and_seminal_plasma_antioxidant_capacity_in_infertile_men_with_idiopathic_oligoasthenoteratozoospermia_ L2 - https://doi.org/10.1002/ptr.3294 DB - PRIME DP - Unbound Medicine ER -