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The peritoneal leptin, MCP-1 and TNF-α in the pathogenesis of endometriosis-associated infertility.
Am J Reprod Immunol 2011; 65(4):403-6AJ

Abstract

PROBLEM

To explore the roles of leptin, monocyte chemotactic protein (MCP)-1, and tumour necrosis factor (TNF)-α in the peritoneal fluid (PF) in the pathogenesis of endometriosis-associated infertility.

METHOD OF STUDY

Leptin, MCP-1, and TNF-α levels in the PF from 28 infertile women with endometriosis (study group), 23 women with fallopian-associated infertility (controls), and 24 women with myoma (controls) were determined by performing enzyme-linked immunosorbent assay (ELISA).

RESULT

Leptin and TNF-α levels in the PF showed no significant difference among three groups. The MCP-1 level in patients with endometriosis was higher than those in fallopian-associated infertility group and myoma group (P < 0.01). There was a positive correlation between leptin and MCP-1 levels in the PF of patients with endometriosis (P < 0.05).

CONCLUSION

Peritoneal leptin and MCP-1 play important roles in the pathogenesis of infertility in the early stage of endometriosis.

Authors+Show Affiliations

Department of Obstetrics/Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20825374

Citation

Tao, Yu, et al. "The Peritoneal Leptin, MCP-1 and TNF-α in the Pathogenesis of Endometriosis-associated Infertility." American Journal of Reproductive Immunology (New York, N.Y. : 1989), vol. 65, no. 4, 2011, pp. 403-6.
Tao Y, Zhang Q, Huang W, et al. The peritoneal leptin, MCP-1 and TNF-α in the pathogenesis of endometriosis-associated infertility. Am J Reprod Immunol. 2011;65(4):403-6.
Tao, Y., Zhang, Q., Huang, W., Zhu, H., Zhang, D., & Luo, W. (2011). The peritoneal leptin, MCP-1 and TNF-α in the pathogenesis of endometriosis-associated infertility. American Journal of Reproductive Immunology (New York, N.Y. : 1989), 65(4), pp. 403-6. doi:10.1111/j.1600-0897.2010.00920.x.
Tao Y, et al. The Peritoneal Leptin, MCP-1 and TNF-α in the Pathogenesis of Endometriosis-associated Infertility. Am J Reprod Immunol. 2011;65(4):403-6. PubMed PMID: 20825374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The peritoneal leptin, MCP-1 and TNF-α in the pathogenesis of endometriosis-associated infertility. AU - Tao,Yu, AU - Zhang,Qiang, AU - Huang,Wei, AU - Zhu,HuiLi, AU - Zhang,Dongxue, AU - Luo,Wanying, Y1 - 2010/09/06/ PY - 2010/9/10/entrez PY - 2010/9/10/pubmed PY - 2011/9/10/medline SP - 403 EP - 6 JF - American journal of reproductive immunology (New York, N.Y. : 1989) JO - Am. J. Reprod. Immunol. VL - 65 IS - 4 N2 - PROBLEM: To explore the roles of leptin, monocyte chemotactic protein (MCP)-1, and tumour necrosis factor (TNF)-α in the peritoneal fluid (PF) in the pathogenesis of endometriosis-associated infertility. METHOD OF STUDY: Leptin, MCP-1, and TNF-α levels in the PF from 28 infertile women with endometriosis (study group), 23 women with fallopian-associated infertility (controls), and 24 women with myoma (controls) were determined by performing enzyme-linked immunosorbent assay (ELISA). RESULT: Leptin and TNF-α levels in the PF showed no significant difference among three groups. The MCP-1 level in patients with endometriosis was higher than those in fallopian-associated infertility group and myoma group (P < 0.01). There was a positive correlation between leptin and MCP-1 levels in the PF of patients with endometriosis (P < 0.05). CONCLUSION: Peritoneal leptin and MCP-1 play important roles in the pathogenesis of infertility in the early stage of endometriosis. SN - 1600-0897 UR - https://www.unboundmedicine.com/medline/citation/20825374/The_peritoneal_leptin_MCP_1_and_TNF_α_in_the_pathogenesis_of_endometriosis_associated_infertility_ L2 - https://doi.org/10.1111/j.1600-0897.2010.00920.x DB - PRIME DP - Unbound Medicine ER -