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Weight loss: a neglected intervention in the management of chronic kidney disease.
Curr Opin Nephrol Hypertens. 2010 Nov; 19(6):534-8.CO

Abstract

PURPOSE OF REVIEW

Obesity is being increasingly implicated as an independent risk factor for the development of chronic kidney disease (CKD), raising the question whether reversing obesity can be utilized as a mainstay or an adjunct therapy for CKD and possibly for its prevention. The purpose of this review is to examine the impact of treatment of obesity on renal outcomes.

RECENT FINDINGS

Many observations have pointed to improvement in renal parameters following weight loss. In fact, both surgical and nonsurgical approaches appear to be effective at reducing blood pressure and proteinuria. Weight loss has also been shown to lower glomerular filtration rate (GFR) in obese patients, not an insignificant benefit considering that intra-glomerular hypertension and the subsequent hyperfiltration in the setting of obesity might be a main driver for the development of CKD.

SUMMARY

Urinary protein excretion, blood pressure, and GFR improve with surgical and nonsurgical weight loss interventions. Whether improvements in these surrogate outcomes after weight loss actually translate into a reduction in the risk of CKD or amelioration in the rate of progression of established CKD is yet to be determined.

Authors+Show Affiliations

Division of Renal Diseases and Hypertension, University of Minnesota, Minneapolis, Minnesota 55414, USA. ibrah007@umn.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20827193

Citation

Ibrahim, Hassan N., and Marc L. Weber. "Weight Loss: a Neglected Intervention in the Management of Chronic Kidney Disease." Current Opinion in Nephrology and Hypertension, vol. 19, no. 6, 2010, pp. 534-8.
Ibrahim HN, Weber ML. Weight loss: a neglected intervention in the management of chronic kidney disease. Curr Opin Nephrol Hypertens. 2010;19(6):534-8.
Ibrahim, H. N., & Weber, M. L. (2010). Weight loss: a neglected intervention in the management of chronic kidney disease. Current Opinion in Nephrology and Hypertension, 19(6), 534-8. https://doi.org/10.1097/MNH.0b013e32833f13de
Ibrahim HN, Weber ML. Weight Loss: a Neglected Intervention in the Management of Chronic Kidney Disease. Curr Opin Nephrol Hypertens. 2010;19(6):534-8. PubMed PMID: 20827193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Weight loss: a neglected intervention in the management of chronic kidney disease. AU - Ibrahim,Hassan N, AU - Weber,Marc L, PY - 2010/9/10/entrez PY - 2010/9/10/pubmed PY - 2011/2/2/medline SP - 534 EP - 8 JF - Current opinion in nephrology and hypertension JO - Curr Opin Nephrol Hypertens VL - 19 IS - 6 N2 - PURPOSE OF REVIEW: Obesity is being increasingly implicated as an independent risk factor for the development of chronic kidney disease (CKD), raising the question whether reversing obesity can be utilized as a mainstay or an adjunct therapy for CKD and possibly for its prevention. The purpose of this review is to examine the impact of treatment of obesity on renal outcomes. RECENT FINDINGS: Many observations have pointed to improvement in renal parameters following weight loss. In fact, both surgical and nonsurgical approaches appear to be effective at reducing blood pressure and proteinuria. Weight loss has also been shown to lower glomerular filtration rate (GFR) in obese patients, not an insignificant benefit considering that intra-glomerular hypertension and the subsequent hyperfiltration in the setting of obesity might be a main driver for the development of CKD. SUMMARY: Urinary protein excretion, blood pressure, and GFR improve with surgical and nonsurgical weight loss interventions. Whether improvements in these surrogate outcomes after weight loss actually translate into a reduction in the risk of CKD or amelioration in the rate of progression of established CKD is yet to be determined. SN - 1473-6543 UR - https://www.unboundmedicine.com/medline/citation/20827193/Weight_loss:_a_neglected_intervention_in_the_management_of_chronic_kidney_disease_ L2 - https://doi.org/10.1097/MNH.0b013e32833f13de DB - PRIME DP - Unbound Medicine ER -