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HELLP syndrome with and without eclampsia.
Am J Perinatol. 2011 Mar; 28(3):187-94.AJ

Abstract

We assessed pregnancy outcomes for patients with HELLP syndrome (hemolysis; elevated liver enzymes; low platelet count) with and without concurrent eclampsia. We performed a retrospective investigation of data spanning three decades of patients with class 1 or 2 HELLP syndrome with concurrent eclampsia (HELLP + E) and patients with HELLP syndrome without eclampsia. Data were analyzed by appropriate tests for continuous or categorical outcomes with differences considered significant if P < 0.05. During 1981 to 1996 and 2000 to 2006, there were 693 patients with class 1 or 2 HELLP syndrome; altogether, 70 patients had HELLP + E. The only demographic difference was greater nulliparity in HELLP + E patients. Otherwise, inconsistent and clinically insignificant differences were observed between groups. Despite the relatively large size of the study groups, we were unable to detect a significant worsening of maternal or perinatal outcome in HELLP + E patients compared with HELLP patients. In our experience, eclampsia does not appear to contribute a significant adverse impact upon the course or outcome of HELLP syndrome pregnancies.

Authors+Show Affiliations

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Winfred L. Wiser Hospital for Women and Infants, University of Mississippi Medical Center, 2500 N. State Street, Jackson, MS 39216, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20827656

Citation

Keiser, Sharon D., et al. "HELLP Syndrome With and Without Eclampsia." American Journal of Perinatology, vol. 28, no. 3, 2011, pp. 187-94.
Keiser SD, Owens MY, Parrish MR, et al. HELLP syndrome with and without eclampsia. Am J Perinatol. 2011;28(3):187-94.
Keiser, S. D., Owens, M. Y., Parrish, M. R., Cushman, J. L., Bufkin, L., May, W. L., & Martin, J. N. (2011). HELLP syndrome with and without eclampsia. American Journal of Perinatology, 28(3), 187-94. https://doi.org/10.1055/s-0030-1266155
Keiser SD, et al. HELLP Syndrome With and Without Eclampsia. Am J Perinatol. 2011;28(3):187-94. PubMed PMID: 20827656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HELLP syndrome with and without eclampsia. AU - Keiser,Sharon D, AU - Owens,Michelle Y, AU - Parrish,Marc R, AU - Cushman,Julie L, AU - Bufkin,Laura, AU - May,Warren L, AU - Martin,James N,Jr Y1 - 2010/09/08/ PY - 2010/9/10/entrez PY - 2010/9/10/pubmed PY - 2011/7/26/medline SP - 187 EP - 94 JF - American journal of perinatology JO - Am J Perinatol VL - 28 IS - 3 N2 - We assessed pregnancy outcomes for patients with HELLP syndrome (hemolysis; elevated liver enzymes; low platelet count) with and without concurrent eclampsia. We performed a retrospective investigation of data spanning three decades of patients with class 1 or 2 HELLP syndrome with concurrent eclampsia (HELLP + E) and patients with HELLP syndrome without eclampsia. Data were analyzed by appropriate tests for continuous or categorical outcomes with differences considered significant if P < 0.05. During 1981 to 1996 and 2000 to 2006, there were 693 patients with class 1 or 2 HELLP syndrome; altogether, 70 patients had HELLP + E. The only demographic difference was greater nulliparity in HELLP + E patients. Otherwise, inconsistent and clinically insignificant differences were observed between groups. Despite the relatively large size of the study groups, we were unable to detect a significant worsening of maternal or perinatal outcome in HELLP + E patients compared with HELLP patients. In our experience, eclampsia does not appear to contribute a significant adverse impact upon the course or outcome of HELLP syndrome pregnancies. SN - 1098-8785 UR - https://www.unboundmedicine.com/medline/citation/20827656/HELLP_syndrome_with_and_without_eclampsia_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0030-1266155 DB - PRIME DP - Unbound Medicine ER -