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Prevention of oxaliplatin-induced mechanical allodynia and neurodegeneration by neurotropin in the rat model.
Eur J Pain. 2011 Apr; 15(4):344-50.EJ

Abstract

Oxaliplatin is a key drug for colorectal cancer, but it causes acute peripheral neuropathy (triggered by cold) and chronic neuropathy (sensory and motor neuropathy) in patients. Neurotropin, a non-protein extract from the inflamed rabbit skin inoculated with vaccinia virus, has been used to treat various chronic pains. In the present study, we investigated the effect of neurotropin on the oxaliplatin-induced neuropathy in rats. Repeated administration of oxaliplatin caused cold hyperalgesia from Day 5 to Day 29 and mechanical allodynia from Day 15 to Day 47. Repeated administration of neurotropin relieved the oxaliplatin-induced mechanical allodynia but not cold hyperalgesia, and inhibited the oxaliplatin-induced axonal degeneration in rat sciatic nerve. Neurotropin also inhibited the oxaliplatin-induced neurite degeneration in cultured pheochromocytoma 12 (PC12) and rat dorsal root ganglion (DRG) cells. On the other hand, neurotropin did not affect the oxaliplatin-induced cell injury in rat DRG cells. These results suggest that repeated administration of neurotropin relieves the oxaliplatin-induced mechanical allodynia by inhibiting the axonal degeneration and it is useful for the treatment of oxaliplatin-induced neuropathy clinically.

Authors+Show Affiliations

Department of Pharmacy, Kyushu University Hospital, Fukuoka 812-8582, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20829082

Citation

Kawashiri, Takehiro, et al. "Prevention of Oxaliplatin-induced Mechanical Allodynia and Neurodegeneration By Neurotropin in the Rat Model." European Journal of Pain (London, England), vol. 15, no. 4, 2011, pp. 344-50.
Kawashiri T, Egashira N, Watanabe H, et al. Prevention of oxaliplatin-induced mechanical allodynia and neurodegeneration by neurotropin in the rat model. Eur J Pain. 2011;15(4):344-50.
Kawashiri, T., Egashira, N., Watanabe, H., Ikegami, Y., Hirakawa, S., Mihara, Y., Yano, T., Ikesue, H., & Oishi, R. (2011). Prevention of oxaliplatin-induced mechanical allodynia and neurodegeneration by neurotropin in the rat model. European Journal of Pain (London, England), 15(4), 344-50. https://doi.org/10.1016/j.ejpain.2010.08.006
Kawashiri T, et al. Prevention of Oxaliplatin-induced Mechanical Allodynia and Neurodegeneration By Neurotropin in the Rat Model. Eur J Pain. 2011;15(4):344-50. PubMed PMID: 20829082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of oxaliplatin-induced mechanical allodynia and neurodegeneration by neurotropin in the rat model. AU - Kawashiri,Takehiro, AU - Egashira,Nobuaki, AU - Watanabe,Hitomi, AU - Ikegami,Yoko, AU - Hirakawa,Shingo, AU - Mihara,Yuki, AU - Yano,Takahisa, AU - Ikesue,Hiroaki, AU - Oishi,Ryozo, Y1 - 2010/09/09/ PY - 2010/02/18/received PY - 2010/07/13/revised PY - 2010/08/13/accepted PY - 2010/9/11/entrez PY - 2010/9/11/pubmed PY - 2011/7/30/medline SP - 344 EP - 50 JF - European journal of pain (London, England) JO - Eur J Pain VL - 15 IS - 4 N2 - Oxaliplatin is a key drug for colorectal cancer, but it causes acute peripheral neuropathy (triggered by cold) and chronic neuropathy (sensory and motor neuropathy) in patients. Neurotropin, a non-protein extract from the inflamed rabbit skin inoculated with vaccinia virus, has been used to treat various chronic pains. In the present study, we investigated the effect of neurotropin on the oxaliplatin-induced neuropathy in rats. Repeated administration of oxaliplatin caused cold hyperalgesia from Day 5 to Day 29 and mechanical allodynia from Day 15 to Day 47. Repeated administration of neurotropin relieved the oxaliplatin-induced mechanical allodynia but not cold hyperalgesia, and inhibited the oxaliplatin-induced axonal degeneration in rat sciatic nerve. Neurotropin also inhibited the oxaliplatin-induced neurite degeneration in cultured pheochromocytoma 12 (PC12) and rat dorsal root ganglion (DRG) cells. On the other hand, neurotropin did not affect the oxaliplatin-induced cell injury in rat DRG cells. These results suggest that repeated administration of neurotropin relieves the oxaliplatin-induced mechanical allodynia by inhibiting the axonal degeneration and it is useful for the treatment of oxaliplatin-induced neuropathy clinically. SN - 1532-2149 UR - https://www.unboundmedicine.com/medline/citation/20829082/Prevention_of_oxaliplatin_induced_mechanical_allodynia_and_neurodegeneration_by_neurotropin_in_the_rat_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090-3801(10)00202-8 DB - PRIME DP - Unbound Medicine ER -