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A reappraisal of the epidemiology of multiple sclerosis in Olmsted County, Minnesota.

Abstract

A review of multiple sclerosis (MS) case reports, using the unified record system at the Mayo Clinic for the Olmsted County population, revealed age- and sex-adjusted prevalence rates per 100,000 persons of 160 for Olmsted County and 173 for Rochester, Minnesota, on January 1, 1985. The annual age- and sex-adjusted incidence rate per 100,000 person-years from 1975 to 1984 for Olmsted County was 6.2 and for Rochester, 6.3. This incidence rate is significantly higher than what had been reported previously in Rochester (3.6/100,000) or in other communities. The estimated 25-year survival of the MS population was 76.2% +/- 4.5% compared with 87.7% for the general US white population of a similar age and sex. Survival for men was less than for women. There was no increase in survival for patients diagnosed with MS in more recent decades. No significant increase was found in cancer or autoimmune disease rates in the MS patients.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, Mayo Clinic, Rochester, MN 55905.

    , ,

    Source

    Neurology 40:5 1990 May pg 780-6

    MeSH

    Adolescent
    Adult
    Aged
    Autoimmune Diseases
    Child
    Child, Preschool
    Female
    Humans
    Infant
    Infant, Newborn
    Male
    Middle Aged
    Minnesota
    Multiple Sclerosis
    Neoplasms
    Risk Factors
    Survival Analysis

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    2082944

    Citation

    Wynn, D R., et al. "A Reappraisal of the Epidemiology of Multiple Sclerosis in Olmsted County, Minnesota." Neurology, vol. 40, no. 5, 1990, pp. 780-6.
    Wynn DR, Rodriguez M, O'Fallon WM, et al. A reappraisal of the epidemiology of multiple sclerosis in Olmsted County, Minnesota. Neurology. 1990;40(5):780-6.
    Wynn, D. R., Rodriguez, M., O'Fallon, W. M., & Kurland, L. T. (1990). A reappraisal of the epidemiology of multiple sclerosis in Olmsted County, Minnesota. Neurology, 40(5), pp. 780-6.
    Wynn DR, et al. A Reappraisal of the Epidemiology of Multiple Sclerosis in Olmsted County, Minnesota. Neurology. 1990;40(5):780-6. PubMed PMID: 2082944.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A reappraisal of the epidemiology of multiple sclerosis in Olmsted County, Minnesota. AU - Wynn,D R, AU - Rodriguez,M, AU - O'Fallon,W M, AU - Kurland,L T, PY - 1990/5/1/pubmed PY - 1990/5/1/medline PY - 1990/5/1/entrez SP - 780 EP - 6 JF - Neurology JO - Neurology VL - 40 IS - 5 N2 - A review of multiple sclerosis (MS) case reports, using the unified record system at the Mayo Clinic for the Olmsted County population, revealed age- and sex-adjusted prevalence rates per 100,000 persons of 160 for Olmsted County and 173 for Rochester, Minnesota, on January 1, 1985. The annual age- and sex-adjusted incidence rate per 100,000 person-years from 1975 to 1984 for Olmsted County was 6.2 and for Rochester, 6.3. This incidence rate is significantly higher than what had been reported previously in Rochester (3.6/100,000) or in other communities. The estimated 25-year survival of the MS population was 76.2% +/- 4.5% compared with 87.7% for the general US white population of a similar age and sex. Survival for men was less than for women. There was no increase in survival for patients diagnosed with MS in more recent decades. No significant increase was found in cancer or autoimmune disease rates in the MS patients. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/2082944/A_reappraisal_of_the_epidemiology_of_multiple_sclerosis_in_Olmsted_County_Minnesota_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=2082944.ui DB - PRIME DP - Unbound Medicine ER -