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Magnetic resonance mammography in small vs. advanced breast lesions - systematic comparison reveals significant impact of lesion size on diagnostic accuracy in 936 histologically verified breast lesions.
Rofo. 2011 Feb; 183(2):126-35.ROFO

Abstract

PURPOSE

This study was conducted to investigate the appearance of breast lesions in MR mammography (MRM) as a function of size and to identify the potential impact on diagnostic accuracy.

MATERIALS AND METHODS

936 histologically verified breast lesions (standardized MRM protocol; consecutive 12-year period at our institution, diameter 5 - 50 mm) were prospectively evaluated in consensus by two radiologists with significant MRM experience. For this purpose previously published descriptors (n = 17) were used. These were summarized as the "basic catalog and extended catalog" of descriptors (BC vs. EC). According to a cut-off of 20 mm, the database was divided into the subgroups "small" (n = 669) and "advanced" (n = 267). The diagnostic accuracy of MRM in these two subgroups was then determined using BC and EC, separately (binary logistic regression analysis; AUC analysis).

RESULTS

The majority of descriptors (n = 11) showed a significantly different prevalence in correlation with size (p < 0.05). The diagnostic accuracy of MRM for "advanced" lesions (AUC = 0.969) was significantly higher (p < 0.001). This difference was significantly decreased (p < 0.001), if instead of BC (AUC = 0.865) EC was applied for the assessment of "small" lesions (AUC: 0.908 vs. 0.865).

CONCLUSION

The typical appearance of breast lesions in MRM depends on lesion size. This resulted in lower diagnostic accuracy in small lesions compared to advanced findings. This difference was able to be significantly decreased by applying the catalog of extended descriptors.

Authors+Show Affiliations

Institut für Diagnostische und Interventionelle Radiologie, Friedrrich-Schiller Universität Jena, Germany. dietzelmatthias2@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20830650

Citation

Dietzel, M, et al. "Magnetic Resonance Mammography in Small Vs. Advanced Breast Lesions - Systematic Comparison Reveals Significant Impact of Lesion Size On Diagnostic Accuracy in 936 Histologically Verified Breast Lesions." RoFo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin, vol. 183, no. 2, 2011, pp. 126-35.
Dietzel M, Baltzer PA, Vag T, et al. Magnetic resonance mammography in small vs. advanced breast lesions - systematic comparison reveals significant impact of lesion size on diagnostic accuracy in 936 histologically verified breast lesions. Rofo. 2011;183(2):126-35.
Dietzel, M., Baltzer, P. A., Vag, T., Gröschel, T., Richter, C., Burmeister, H., & Kaiser, W. A. (2011). Magnetic resonance mammography in small vs. advanced breast lesions - systematic comparison reveals significant impact of lesion size on diagnostic accuracy in 936 histologically verified breast lesions. RoFo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin, 183(2), 126-35. https://doi.org/10.1055/s-0029-1245630
Dietzel M, et al. Magnetic Resonance Mammography in Small Vs. Advanced Breast Lesions - Systematic Comparison Reveals Significant Impact of Lesion Size On Diagnostic Accuracy in 936 Histologically Verified Breast Lesions. Rofo. 2011;183(2):126-35. PubMed PMID: 20830650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnetic resonance mammography in small vs. advanced breast lesions - systematic comparison reveals significant impact of lesion size on diagnostic accuracy in 936 histologically verified breast lesions. AU - Dietzel,M, AU - Baltzer,P A, AU - Vag,T, AU - Gröschel,T, AU - Richter,C, AU - Burmeister,H, AU - Kaiser,W A, Y1 - 2010/09/09/ PY - 2010/9/11/entrez PY - 2010/9/11/pubmed PY - 2011/3/16/medline SP - 126 EP - 35 JF - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin JO - Rofo VL - 183 IS - 2 N2 - PURPOSE: This study was conducted to investigate the appearance of breast lesions in MR mammography (MRM) as a function of size and to identify the potential impact on diagnostic accuracy. MATERIALS AND METHODS: 936 histologically verified breast lesions (standardized MRM protocol; consecutive 12-year period at our institution, diameter 5 - 50 mm) were prospectively evaluated in consensus by two radiologists with significant MRM experience. For this purpose previously published descriptors (n = 17) were used. These were summarized as the "basic catalog and extended catalog" of descriptors (BC vs. EC). According to a cut-off of 20 mm, the database was divided into the subgroups "small" (n = 669) and "advanced" (n = 267). The diagnostic accuracy of MRM in these two subgroups was then determined using BC and EC, separately (binary logistic regression analysis; AUC analysis). RESULTS: The majority of descriptors (n = 11) showed a significantly different prevalence in correlation with size (p < 0.05). The diagnostic accuracy of MRM for "advanced" lesions (AUC = 0.969) was significantly higher (p < 0.001). This difference was significantly decreased (p < 0.001), if instead of BC (AUC = 0.865) EC was applied for the assessment of "small" lesions (AUC: 0.908 vs. 0.865). CONCLUSION: The typical appearance of breast lesions in MRM depends on lesion size. This resulted in lower diagnostic accuracy in small lesions compared to advanced findings. This difference was able to be significantly decreased by applying the catalog of extended descriptors. SN - 1438-9010 UR - https://www.unboundmedicine.com/medline/citation/20830650/Magnetic_resonance_mammography_in_small_vs__advanced_breast_lesions___systematic_comparison_reveals_significant_impact_of_lesion_size_on_diagnostic_accuracy_in_936_histologically_verified_breast_lesions_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0029-1245630 DB - PRIME DP - Unbound Medicine ER -