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The effect of high dose of N-acetylcysteine in lupus nephritis: a case report and literature review.
J Clin Pharm Ther 2010; 35(4):483-5JC

Abstract

An imbalance of oxidative-antioxidant defence mechanism has been proposed in systemic lupus erythematosus patients. Co-administration of N-acetylcysteine (NAC) which has a strong antioxidant activity may produce a satisfactory therapeutic outcome when added to standard therapy. We report a case of a 46-year-old lupus nephritis patient who received 1800 mg of NAC orally. After NAC, this patient showed a higher glutathione level, and a normal level of malondialdehyde, a lipid peroxidation product. In addition, the urinary protein levels, the complete blood counts and physical examination of the affected organs showed improvement. However, a well-controlled trial is needed to confirm the value of high-dose NAC in lupus nephritis patients.

Authors+Show Affiliations

Faculty of Pharmacy, Silpakorn University, Thailand. karunrat@email.pharm.su.ac.thNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

20831550

Citation

Tewthanom, K, et al. "The Effect of High Dose of N-acetylcysteine in Lupus Nephritis: a Case Report and Literature Review." Journal of Clinical Pharmacy and Therapeutics, vol. 35, no. 4, 2010, pp. 483-5.
Tewthanom K, Janwitayanujit S, Totemchockcyakarn K, et al. The effect of high dose of N-acetylcysteine in lupus nephritis: a case report and literature review. J Clin Pharm Ther. 2010;35(4):483-5.
Tewthanom, K., Janwitayanujit, S., Totemchockcyakarn, K., & Panomvana Na Ayudhya, D. (2010). The effect of high dose of N-acetylcysteine in lupus nephritis: a case report and literature review. Journal of Clinical Pharmacy and Therapeutics, 35(4), pp. 483-5. doi:10.1111/j.1365-2710.2009.01108.x.
Tewthanom K, et al. The Effect of High Dose of N-acetylcysteine in Lupus Nephritis: a Case Report and Literature Review. J Clin Pharm Ther. 2010;35(4):483-5. PubMed PMID: 20831550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of high dose of N-acetylcysteine in lupus nephritis: a case report and literature review. AU - Tewthanom,K, AU - Janwitayanujit,S, AU - Totemchockcyakarn,K, AU - Panomvana Na Ayudhya,D, PY - 2010/9/14/entrez PY - 2010/9/14/pubmed PY - 2010/12/28/medline SP - 483 EP - 5 JF - Journal of clinical pharmacy and therapeutics JO - J Clin Pharm Ther VL - 35 IS - 4 N2 - An imbalance of oxidative-antioxidant defence mechanism has been proposed in systemic lupus erythematosus patients. Co-administration of N-acetylcysteine (NAC) which has a strong antioxidant activity may produce a satisfactory therapeutic outcome when added to standard therapy. We report a case of a 46-year-old lupus nephritis patient who received 1800 mg of NAC orally. After NAC, this patient showed a higher glutathione level, and a normal level of malondialdehyde, a lipid peroxidation product. In addition, the urinary protein levels, the complete blood counts and physical examination of the affected organs showed improvement. However, a well-controlled trial is needed to confirm the value of high-dose NAC in lupus nephritis patients. SN - 1365-2710 UR - https://www.unboundmedicine.com/medline/citation/20831550/full_citation L2 - https://doi.org/10.1111/j.1365-2710.2009.01108.x DB - PRIME DP - Unbound Medicine ER -