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The role of non-HLA single nucleotide polymorphisms in multiple sclerosis susceptibility.
J Neuroimmunol 2010; 229(1-2):5-15JN

Abstract

Multiple sclerosis (MS) is the most common neurological disease of the central nervous system affecting young adults. While the etiology of the disease is still unknown, epidemiological and genetics studies have shown a significant inherited component involved in MS pathogenesis. Single nucleotide polymorphisms (SNPs) associated with MS have been recently evaluated by two main groups of high-throughput genotyping analyses: candidate gene approaches and genome-wide association studies (GWAS). Although both types of studies have identified polymorphisms in the human leukocyte antigen (HLA) region as the strongest susceptibility loci for MS, recent investigations have identified a broad spectrum of non-HLA genes prominently associated with MS. This review will focus on recent findings in non-HLA genes as well as their SNPs which have shown high linkage to MS as a genetic-based disorder. Understanding of non-HLA polymorphisms will help elucidate the signalling aberrations involved in MS development and may help to identify novel, personalized approaches to therapy.

Authors+Show Affiliations

Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20832869

Citation

Bahreini, Seyed Amir, et al. "The Role of non-HLA Single Nucleotide Polymorphisms in Multiple Sclerosis Susceptibility." Journal of Neuroimmunology, vol. 229, no. 1-2, 2010, pp. 5-15.
Bahreini SA, Jabalameli MR, Saadatnia M, et al. The role of non-HLA single nucleotide polymorphisms in multiple sclerosis susceptibility. J Neuroimmunol. 2010;229(1-2):5-15.
Bahreini, S. A., Jabalameli, M. R., Saadatnia, M., & Zahednasab, H. (2010). The role of non-HLA single nucleotide polymorphisms in multiple sclerosis susceptibility. Journal of Neuroimmunology, 229(1-2), pp. 5-15. doi:10.1016/j.jneuroim.2010.08.002.
Bahreini SA, et al. The Role of non-HLA Single Nucleotide Polymorphisms in Multiple Sclerosis Susceptibility. J Neuroimmunol. 2010 Dec 15;229(1-2):5-15. PubMed PMID: 20832869.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of non-HLA single nucleotide polymorphisms in multiple sclerosis susceptibility. AU - Bahreini,Seyed Amir, AU - Jabalameli,M Reza, AU - Saadatnia,Mohammad, AU - Zahednasab,Hamid, Y1 - 2010/09/15/ PY - 2010/05/13/received PY - 2010/07/19/revised PY - 2010/08/04/accepted PY - 2010/9/14/entrez PY - 2010/9/14/pubmed PY - 2010/12/18/medline SP - 5 EP - 15 JF - Journal of neuroimmunology JO - J. Neuroimmunol. VL - 229 IS - 1-2 N2 - Multiple sclerosis (MS) is the most common neurological disease of the central nervous system affecting young adults. While the etiology of the disease is still unknown, epidemiological and genetics studies have shown a significant inherited component involved in MS pathogenesis. Single nucleotide polymorphisms (SNPs) associated with MS have been recently evaluated by two main groups of high-throughput genotyping analyses: candidate gene approaches and genome-wide association studies (GWAS). Although both types of studies have identified polymorphisms in the human leukocyte antigen (HLA) region as the strongest susceptibility loci for MS, recent investigations have identified a broad spectrum of non-HLA genes prominently associated with MS. This review will focus on recent findings in non-HLA genes as well as their SNPs which have shown high linkage to MS as a genetic-based disorder. Understanding of non-HLA polymorphisms will help elucidate the signalling aberrations involved in MS development and may help to identify novel, personalized approaches to therapy. SN - 1872-8421 UR - https://www.unboundmedicine.com/medline/citation/20832869/The_role_of_non_HLA_single_nucleotide_polymorphisms_in_multiple_sclerosis_susceptibility_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5728(10)00346-2 DB - PRIME DP - Unbound Medicine ER -