Tags

Type your tag names separated by a space and hit enter

Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.
Gut 2010; 59(11):1457-64Gut

Abstract

BACKGROUND

Oesophageal squamous cell carcinoma (OSCC) is considered a difficult cancer to cure. The detection of environmental and genetic factors is important for prevention on an individual basis.

OBJECTIVE

To identify groups at high risk for OSCC by simultaneously analysing both genetic and environmental risk factors. Methods A multistage genome-wide association study of OSCC in Japanese individuals with a total of 1071 cases and 2762 controls was performed.

RESULTS

Two associated single-nucleotide polymorphisms (SNPs), as well as smoking and alcohol consumption, were evaluated as genetic and environmental risk factors, respectively, and their interactions were also evaluated. Risk alleles of rs1229984 (ADH1B) and rs671 (ALDH2) were highly associated with OSCC (odds ratio (OR)=4.08, p=4.4×10(-40) and OR=4.13, p=8.4×10(-76), respectively). Also, smoking and alcohol consumption were identified as risk factors for OSCC development. By integrating both genetic and environmental risk factors, it was shown that the combination of rs1229984 and rs671 risk alleles with smoking and alcohol consumption was associated with OSCC. Compared with subjects with no more than one environmental or genetic risk factor, the OR reached 146.4 (95% CI 50.5 to 424.5) when both environmental and genetic risk factors were present. Without the genetic risks, alcohol consumption did not correlate with OSCC. In people with one or two genetic risk factors, the combination of alcohol consumption and smoking increased OSCC risk.

CONCLUSIONS

Analysis of ADH1B and ALDH2 variants is valuable for secondary prevention of OSCC in high-risk patients who smoke and drink alcohol. In this study, SNP genotyping demonstrated that the ADH1B and/or ALDH2 risk alleles had an interaction with smoking and, especially, alcohol consumption. These findings, if replicated in other groups, could demonstrate new pathophysiological pathways for the development of OSCC.

Authors+Show Affiliations

Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

20833657

Citation

Tanaka, Fumiaki, et al. "Strong Interaction Between the Effects of Alcohol Consumption and Smoking On Oesophageal Squamous Cell Carcinoma Among Individuals With ADH1B And/or ALDH2 Risk Alleles." Gut, vol. 59, no. 11, 2010, pp. 1457-64.
Tanaka F, Yamamoto K, Suzuki S, et al. Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles. Gut. 2010;59(11):1457-64.
Tanaka, F., Yamamoto, K., Suzuki, S., Inoue, H., Tsurumaru, M., Kajiyama, Y., ... Mori, M. (2010). Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles. Gut, 59(11), pp. 1457-64. doi:10.1136/gut.2009.205724.
Tanaka F, et al. Strong Interaction Between the Effects of Alcohol Consumption and Smoking On Oesophageal Squamous Cell Carcinoma Among Individuals With ADH1B And/or ALDH2 Risk Alleles. Gut. 2010;59(11):1457-64. PubMed PMID: 20833657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles. AU - Tanaka,Fumiaki, AU - Yamamoto,Ken, AU - Suzuki,Sadao, AU - Inoue,Hiroshi, AU - Tsurumaru,Masahiko, AU - Kajiyama,Yoshiaki, AU - Kato,Hoichi, AU - Igaki,Hiroyasu, AU - Furuta,Koh, AU - Fujita,Hiromasa, AU - Tanaka,Toshiaki, AU - Tanaka,Yoichi, AU - Kawashima,Yoshiyuki, AU - Natsugoe,Shoji, AU - Setoyama,Tetsuro, AU - Tokudome,Shinkan, AU - Mimori,Koshi, AU - Haraguchi,Naotsugu, AU - Ishii,Hideshi, AU - Mori,Masaki, Y1 - 2010/09/09/ PY - 2010/9/14/entrez PY - 2010/9/14/pubmed PY - 2010/11/5/medline SP - 1457 EP - 64 JF - Gut JO - Gut VL - 59 IS - 11 N2 - BACKGROUND: Oesophageal squamous cell carcinoma (OSCC) is considered a difficult cancer to cure. The detection of environmental and genetic factors is important for prevention on an individual basis. OBJECTIVE: To identify groups at high risk for OSCC by simultaneously analysing both genetic and environmental risk factors. Methods A multistage genome-wide association study of OSCC in Japanese individuals with a total of 1071 cases and 2762 controls was performed. RESULTS: Two associated single-nucleotide polymorphisms (SNPs), as well as smoking and alcohol consumption, were evaluated as genetic and environmental risk factors, respectively, and their interactions were also evaluated. Risk alleles of rs1229984 (ADH1B) and rs671 (ALDH2) were highly associated with OSCC (odds ratio (OR)=4.08, p=4.4×10(-40) and OR=4.13, p=8.4×10(-76), respectively). Also, smoking and alcohol consumption were identified as risk factors for OSCC development. By integrating both genetic and environmental risk factors, it was shown that the combination of rs1229984 and rs671 risk alleles with smoking and alcohol consumption was associated with OSCC. Compared with subjects with no more than one environmental or genetic risk factor, the OR reached 146.4 (95% CI 50.5 to 424.5) when both environmental and genetic risk factors were present. Without the genetic risks, alcohol consumption did not correlate with OSCC. In people with one or two genetic risk factors, the combination of alcohol consumption and smoking increased OSCC risk. CONCLUSIONS: Analysis of ADH1B and ALDH2 variants is valuable for secondary prevention of OSCC in high-risk patients who smoke and drink alcohol. In this study, SNP genotyping demonstrated that the ADH1B and/or ALDH2 risk alleles had an interaction with smoking and, especially, alcohol consumption. These findings, if replicated in other groups, could demonstrate new pathophysiological pathways for the development of OSCC. SN - 1468-3288 UR - https://www.unboundmedicine.com/medline/citation/20833657/Strong_interaction_between_the_effects_of_alcohol_consumption_and_smoking_on_oesophageal_squamous_cell_carcinoma_among_individuals_with_ADH1B_and/or_ALDH2_risk_alleles_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=20833657 DB - PRIME DP - Unbound Medicine ER -