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Chloral hydrate to study auditory brainstem response.
Braz J Otorhinolaryngol 2010 Jul-Aug; 76(4):433-6BJ

Abstract

Chloral Hydrate (CH) is a sedative and hypnotic drug used in pediatric procedures owing to the low depressive effect it has on the respiratory and cardiac systems.

AIM

To assess the efficacy of the drug in performing ABR and to systematize its use.

MATERIALS AND METHODS

A prospective cross-sectional study with 41 children without history of heart or lung disease. The initial dose of CH at 10% was 50 mg/Kg, with a boost dose of 6 mg/Kg administered 30 minutes later in cases in which there was no sedation. Drug effectiveness was established by sleep induction by 1 hour after the administration of the initial dose. Sleep occurrence was correlated with doses (50 mg or 56 mg/Kg), age, weight and gender.

RESULTS

All the 41 children who participated in the study took 50 mg/kg of the agent and 23 of them slept within 30 minutes, 2 had respiratory complications, 16 had the 6 mg/Kg boost dose and 13 fell asleep after 30 minutes. The 56 mg/kg dose presented a statistically significant effect on sleep induction (p<0.05) when compared to the 50mg/kg dose.

CONCLUSION

CH produced a satisfactory effect with 50 mg/Kg dose plus 6 mg/kg up to one hour after administration. Complications can occur regardless of the dose used.

Authors+Show Affiliations

Otorhinolaryngology Department - FMUSP, ENT - DERDIC/PUCSP. lopessquare@ig.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng por

PubMed ID

20835528

Citation

Fávero, Mariana Lopes, et al. "Chloral Hydrate to Study Auditory Brainstem Response." Brazilian Journal of Otorhinolaryngology, vol. 76, no. 4, 2010, pp. 433-6.
Fávero ML, Ponce FA, Pio MR, et al. Chloral hydrate to study auditory brainstem response. Braz J Otorhinolaryngol. 2010;76(4):433-6.
Fávero, M. L., Ponce, F. A., Pio, M. R., Tabith Junior, A., & Carvalho e Silva, F. L. (2010). Chloral hydrate to study auditory brainstem response. Brazilian Journal of Otorhinolaryngology, 76(4), pp. 433-6.
Fávero ML, et al. Chloral Hydrate to Study Auditory Brainstem Response. Braz J Otorhinolaryngol. 2010;76(4):433-6. PubMed PMID: 20835528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chloral hydrate to study auditory brainstem response. AU - Fávero,Mariana Lopes, AU - Ponce,Fabiana Amaral Sanches, AU - Pio,Marcio Ricardo Barros, AU - Tabith Junior,Alfredo, AU - Carvalho e Silva,Fernando Leite, PY - 2009/08/12/received PY - 2009/11/20/accepted PY - 2010/9/14/entrez PY - 2010/9/14/pubmed PY - 2011/3/8/medline SP - 433 EP - 6 JF - Brazilian journal of otorhinolaryngology JO - Braz J Otorhinolaryngol VL - 76 IS - 4 N2 - UNLABELLED: Chloral Hydrate (CH) is a sedative and hypnotic drug used in pediatric procedures owing to the low depressive effect it has on the respiratory and cardiac systems. AIM: To assess the efficacy of the drug in performing ABR and to systematize its use. MATERIALS AND METHODS: A prospective cross-sectional study with 41 children without history of heart or lung disease. The initial dose of CH at 10% was 50 mg/Kg, with a boost dose of 6 mg/Kg administered 30 minutes later in cases in which there was no sedation. Drug effectiveness was established by sleep induction by 1 hour after the administration of the initial dose. Sleep occurrence was correlated with doses (50 mg or 56 mg/Kg), age, weight and gender. RESULTS: All the 41 children who participated in the study took 50 mg/kg of the agent and 23 of them slept within 30 minutes, 2 had respiratory complications, 16 had the 6 mg/Kg boost dose and 13 fell asleep after 30 minutes. The 56 mg/kg dose presented a statistically significant effect on sleep induction (p<0.05) when compared to the 50mg/kg dose. CONCLUSION: CH produced a satisfactory effect with 50 mg/Kg dose plus 6 mg/kg up to one hour after administration. Complications can occur regardless of the dose used. SN - 1808-8686 UR - https://www.unboundmedicine.com/medline/citation/20835528/Chloral_hydrate_to_study_auditory_brainstem_response_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1808-8694(15)30337-2 DB - PRIME DP - Unbound Medicine ER -