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The aetiology of upper aerodigestive tract cancers among young adults in Europe: the ARCAGE study.
Cancer Causes Control. 2010 Dec; 21(12):2213-21.CC

Abstract

BACKGROUND

The incidence of cancers of the upper aerodigestive tract (UADT) is increasing throughout the world. To date the increases have been proportionally greatest among young people. Several reports have suggested that they often do not have a history of tobacco smoking or heavy alcohol consumption.

OBJECTIVE

To determine the contribution of lifestyle factors to the etiology of UADT cancers occurring in those aged less than 50 years.

METHODS

A case-control study was conducted in 10 European countries. Cases were cancers of the oral cavity and pharynx, larynx and esophagus, and hospital or population controls were age and sex matched.

RESULTS

There were 356 cases younger than 50 years and 419 controls. Risk was strongly related to current smoking [odds ratio (OR) 5.5 95%; confidence interval (CI) (3.3, 9.2)], and risk increased with number of pack-years smoked. Risk was also related to alcohol consumption for both current (OR 1.8; 0.97, 3.3) and past (OR 3.4; 1.6, 7.4) drinkers, and risk increased with number of drink-years. Persons frequently consuming fruits and vegetables were at significantly reduced risk.

CONCLUSIONS

Risk factors already identified as being important for UADT cancers in adults are also important influences on risk in younger adults. The implication of these results is that the public health message in preventing UADT cancers remains the same to young and old alike.

Authors+Show Affiliations

School of Medicine and Dentistry, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK. Tatiana.Macfarlane@abdn.ac.uk.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20835759

Citation

Macfarlane, Tatiana V., et al. "The Aetiology of Upper Aerodigestive Tract Cancers Among Young Adults in Europe: the ARCAGE Study." Cancer Causes & Control : CCC, vol. 21, no. 12, 2010, pp. 2213-21.
Macfarlane TV, Macfarlane GJ, Oliver RJ, et al. The aetiology of upper aerodigestive tract cancers among young adults in Europe: the ARCAGE study. Cancer Causes Control. 2010;21(12):2213-21.
Macfarlane, T. V., Macfarlane, G. J., Oliver, R. J., Benhamou, S., Bouchardy, C., Ahrens, W., Pohlabeln, H., Lagiou, P., Lagiou, A., Castellsague, X., Agudo, A., Merletti, F., Richiardi, L., Kjaerheim, K., Slamova, A., Schejbalova, M., Canova, C., Simonato, L., Talamini, R., ... Brennan, P. (2010). The aetiology of upper aerodigestive tract cancers among young adults in Europe: the ARCAGE study. Cancer Causes & Control : CCC, 21(12), 2213-21. https://doi.org/10.1007/s10552-010-9641-3
Macfarlane TV, et al. The Aetiology of Upper Aerodigestive Tract Cancers Among Young Adults in Europe: the ARCAGE Study. Cancer Causes Control. 2010;21(12):2213-21. PubMed PMID: 20835759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The aetiology of upper aerodigestive tract cancers among young adults in Europe: the ARCAGE study. AU - Macfarlane,Tatiana V, AU - Macfarlane,Gary J, AU - Oliver,Richard J, AU - Benhamou,Simone, AU - Bouchardy,Christine, AU - Ahrens,Wolfgang, AU - Pohlabeln,Hermann, AU - Lagiou,Pagona, AU - Lagiou,Areti, AU - Castellsague,Xavier, AU - Agudo,Antonio, AU - Merletti,Franco, AU - Richiardi,Lorenzo, AU - Kjaerheim,Kristina, AU - Slamova,Alena, AU - Schejbalova,Miriam, AU - Canova,Cristina, AU - Simonato,Lorenzo, AU - Talamini,Renato, AU - Barzan,Luigi, AU - Conway,David I, AU - McKinney,Patricia A, AU - Znaor,Ariana, AU - Lowry,Raymond J, AU - Thomson,Peter, AU - Healy,Claire M, AU - McCartan,Bernard E, AU - Marron,Manuela, AU - Hashibe,Mia, AU - Brennan,Paul, Y1 - 2010/09/11/ PY - 2009/11/20/received PY - 2010/08/26/accepted PY - 2010/9/14/entrez PY - 2010/9/14/pubmed PY - 2011/4/28/medline SP - 2213 EP - 21 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 21 IS - 12 N2 - BACKGROUND: The incidence of cancers of the upper aerodigestive tract (UADT) is increasing throughout the world. To date the increases have been proportionally greatest among young people. Several reports have suggested that they often do not have a history of tobacco smoking or heavy alcohol consumption. OBJECTIVE: To determine the contribution of lifestyle factors to the etiology of UADT cancers occurring in those aged less than 50 years. METHODS: A case-control study was conducted in 10 European countries. Cases were cancers of the oral cavity and pharynx, larynx and esophagus, and hospital or population controls were age and sex matched. RESULTS: There were 356 cases younger than 50 years and 419 controls. Risk was strongly related to current smoking [odds ratio (OR) 5.5 95%; confidence interval (CI) (3.3, 9.2)], and risk increased with number of pack-years smoked. Risk was also related to alcohol consumption for both current (OR 1.8; 0.97, 3.3) and past (OR 3.4; 1.6, 7.4) drinkers, and risk increased with number of drink-years. Persons frequently consuming fruits and vegetables were at significantly reduced risk. CONCLUSIONS: Risk factors already identified as being important for UADT cancers in adults are also important influences on risk in younger adults. The implication of these results is that the public health message in preventing UADT cancers remains the same to young and old alike. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/20835759/The_aetiology_of_upper_aerodigestive_tract_cancers_among_young_adults_in_Europe:_the_ARCAGE_study_ L2 - https://doi.org/10.1007/s10552-010-9641-3 DB - PRIME DP - Unbound Medicine ER -