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Marked interindividual variability in renal maturation of preterm infants: lessons from autopsy.
J Matern Fetal Neonatal Med 2010; 23 Suppl 3:129-33JM

Abstract

The kidney of low birthweight preterm infants is characterized by a reduced number of mature nephrons at birth. The aim of the present study was to determine whether, in preterms, active glomerulogenesis occurs in the postnatal period and whether it may compensate the reduced number of nephrons developed during the intrauterine life. Kidney samples were obtained at autopsy from 8 human fetuses, 12 premature infants, and 3 term newborns. Glomerulogenesis, as measured by radial glomerular count (RGC), was markedly decreased in all preterm infants as compared with term newborns. A marked interindividual variability was detected in the level of glomerulogenesis, which, in the vast majority of cases, did neither correlate with the gestational age at birth nor with birthweight. Active glomerulogenesis, as demonstrated by the presence of S-shaped bodies in the subcapsular region, was present in all preterm infants in the perinatal period, but it ceased in a preterm surviving for 3 months. Our data show that active glomerulogenesis continues even after birth for a short period, although it is not able to compensate a marked oligonephronia at birth. As a consequence, the incomplete nephrogenesis typical of all extremely low birthweight preterm infants possibly results in a persistent oligonephronia which should likelihood represent a major risk factors of progressive renal disease in adulthood.

Authors+Show Affiliations

Department of Pathology, Puericultura Institute and Neonatal Section, University of Cagliari, Via Ospedale 54, Cagliari, Italy. gavinofaa@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20836739

Citation

Faa, Gavino, et al. "Marked Interindividual Variability in Renal Maturation of Preterm Infants: Lessons From Autopsy." The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 23 Suppl 3, 2010, pp. 129-33.
Faa G, Gerosa C, Fanni D, et al. Marked interindividual variability in renal maturation of preterm infants: lessons from autopsy. J Matern Fetal Neonatal Med. 2010;23 Suppl 3:129-33.
Faa, G., Gerosa, C., Fanni, D., Nemolato, S., Locci, A., Cabras, T., ... Fanos, V. (2010). Marked interindividual variability in renal maturation of preterm infants: lessons from autopsy. The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 23 Suppl 3, pp. 129-33. doi:10.3109/14767058.2010.510646.
Faa G, et al. Marked Interindividual Variability in Renal Maturation of Preterm Infants: Lessons From Autopsy. J Matern Fetal Neonatal Med. 2010;23 Suppl 3:129-33. PubMed PMID: 20836739.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marked interindividual variability in renal maturation of preterm infants: lessons from autopsy. AU - Faa,Gavino, AU - Gerosa,Clara, AU - Fanni,Daniela, AU - Nemolato,Sonia, AU - Locci,Annalisa, AU - Cabras,Tiziana, AU - Marinelli,Viviana, AU - Puddu,Melania, AU - Zaffanello,Marco, AU - Monga,Guido, AU - Fanos,Vassilios, PY - 2010/9/15/entrez PY - 2010/9/15/pubmed PY - 2011/2/8/medline SP - 129 EP - 33 JF - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JO - J. Matern. Fetal. Neonatal. Med. VL - 23 Suppl 3 N2 - The kidney of low birthweight preterm infants is characterized by a reduced number of mature nephrons at birth. The aim of the present study was to determine whether, in preterms, active glomerulogenesis occurs in the postnatal period and whether it may compensate the reduced number of nephrons developed during the intrauterine life. Kidney samples were obtained at autopsy from 8 human fetuses, 12 premature infants, and 3 term newborns. Glomerulogenesis, as measured by radial glomerular count (RGC), was markedly decreased in all preterm infants as compared with term newborns. A marked interindividual variability was detected in the level of glomerulogenesis, which, in the vast majority of cases, did neither correlate with the gestational age at birth nor with birthweight. Active glomerulogenesis, as demonstrated by the presence of S-shaped bodies in the subcapsular region, was present in all preterm infants in the perinatal period, but it ceased in a preterm surviving for 3 months. Our data show that active glomerulogenesis continues even after birth for a short period, although it is not able to compensate a marked oligonephronia at birth. As a consequence, the incomplete nephrogenesis typical of all extremely low birthweight preterm infants possibly results in a persistent oligonephronia which should likelihood represent a major risk factors of progressive renal disease in adulthood. SN - 1476-4954 UR - https://www.unboundmedicine.com/medline/citation/20836739/Marked_interindividual_variability_in_renal_maturation_of_preterm_infants:_lessons_from_autopsy L2 - http://www.tandfonline.com/doi/full/10.3109/14767058.2010.510646 DB - PRIME DP - Unbound Medicine ER -