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Attenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal gray.
Exp Neurol. 2010 Dec; 226(2):293-300.EN

Abstract

Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) has frequently been shown to induce escape and freezing/decreased locomotion responses which mimic panic- and fear-like behaviour. In the present study we tested whether such spontaneous fear-like behaviour could be observed in an open-field test 12 h after dlPAG stimulation. Further, we tested whether this fear-like behaviour could be attenuated by acute or chronic administration of buspirone and escitalopram. Our data demonstrate for the first time that animals showed fear-like behaviour 12 h after dlPAG stimulation, which may possibly reflect panic disorder with anticipatory anxiety/agoraphobic symptoms. Acute and chronic escitalopram, but not buspirone, treatment attenuated the fear-related behaviour. Besides, our data also showed that the stimulation intensities to evoke an escape reaction, a panicogenic response, were significantly higher after chronic buspirone and escitalopram treatment. These results suggest that the fear-like response, which was observed 12 h after dlPAG stimulation, could be considered as a relevant animal model for panic disorder with anticipatory anxiety/agoraphobic symptoms.

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Authors+Show Affiliations

Lim LW
Department of Neuroscience, Maastricht University, Faculty of Health, Medicine and Life Sciences, Maastricht, The Netherlands. lw.lim@maastrichtuniversity.nl
Blokland A
No affiliation info available
Tan S
No affiliation info available
Vlamings R
No affiliation info available
Sesia T
No affiliation info available
Aziz-Mohammadi M
No affiliation info available
Visser-Vandewalle V
No affiliation info available
Steinbusch HW
No affiliation info available
Schruers K
No affiliation info available
Temel Y
No affiliation info available

MeSH

AnimalsAnti-Anxiety AgentsAntidepressive Agents, Second-GenerationBuspironeCitalopramDeep Brain StimulationEscape ReactionExploratory BehaviorFearLocomotionMalePeriaqueductal GrayRandom AllocationRatsRats, Wistar

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20837005

Citation

Lim, Lee Wei, et al. "Attenuation of Fear-like Response By Escitalopram Treatment After Electrical Stimulation of the Midbrain Dorsolateral Periaqueductal Gray." Experimental Neurology, vol. 226, no. 2, 2010, pp. 293-300.
Lim LW, Blokland A, Tan S, et al. Attenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal gray. Exp Neurol. 2010;226(2):293-300.
Lim, L. W., Blokland, A., Tan, S., Vlamings, R., Sesia, T., Aziz-Mohammadi, M., Visser-Vandewalle, V., Steinbusch, H. W., Schruers, K., & Temel, Y. (2010). Attenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal gray. Experimental Neurology, 226(2), 293-300. https://doi.org/10.1016/j.expneurol.2010.08.035
Lim LW, et al. Attenuation of Fear-like Response By Escitalopram Treatment After Electrical Stimulation of the Midbrain Dorsolateral Periaqueductal Gray. Exp Neurol. 2010;226(2):293-300. PubMed PMID: 20837005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal gray. AU - Lim,Lee Wei, AU - Blokland,Arjan, AU - Tan,Sonny, AU - Vlamings,Rinske, AU - Sesia,Thibaut, AU - Aziz-Mohammadi,Mujzgan, AU - Visser-Vandewalle,Veerle, AU - Steinbusch,Harry W M, AU - Schruers,Koen, AU - Temel,Yasin, Y1 - 2010/09/15/ PY - 2010/07/16/received PY - 2010/08/26/revised PY - 2010/08/30/accepted PY - 2010/9/15/entrez PY - 2010/9/15/pubmed PY - 2010/11/13/medline SP - 293 EP - 300 JF - Experimental neurology JO - Exp Neurol VL - 226 IS - 2 N2 - Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) has frequently been shown to induce escape and freezing/decreased locomotion responses which mimic panic- and fear-like behaviour. In the present study we tested whether such spontaneous fear-like behaviour could be observed in an open-field test 12 h after dlPAG stimulation. Further, we tested whether this fear-like behaviour could be attenuated by acute or chronic administration of buspirone and escitalopram. Our data demonstrate for the first time that animals showed fear-like behaviour 12 h after dlPAG stimulation, which may possibly reflect panic disorder with anticipatory anxiety/agoraphobic symptoms. Acute and chronic escitalopram, but not buspirone, treatment attenuated the fear-related behaviour. Besides, our data also showed that the stimulation intensities to evoke an escape reaction, a panicogenic response, were significantly higher after chronic buspirone and escitalopram treatment. These results suggest that the fear-like response, which was observed 12 h after dlPAG stimulation, could be considered as a relevant animal model for panic disorder with anticipatory anxiety/agoraphobic symptoms. SN - 1090-2430 UR - https://www.unboundmedicine.com/medline/citation/20837005/Attenuation_of_fear_like_response_by_escitalopram_treatment_after_electrical_stimulation_of_the_midbrain_dorsolateral_periaqueductal_gray_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4886(10)00338-9 DB - PRIME DP - Unbound Medicine ER -