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Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis.
Vaccine. 2010 Nov 03; 28(47):7551-5.V

Abstract

Burkholderia thailandensis is a less virulent close relative of Burkholderia pseudomallei, a CDC category B biothreat agent. We have previously shown that lipopolysaccharide (LPS) extracted from B. pseudomallei can provide protection against a lethal challenge of B. pseudomallei in a mouse model of melioidosis. Sugar analysis on LPS from B. thailandensis strain E264 confirmed that this polysaccharide has a similar structure to LPS from B. pseudomallei. Mice were immunised with LPS from B. thailandensis or B. pseudomallei and challenged with a lethal dose of B. pseudomallei strain K96243. Similar protection levels were observed when either LPS was used as the immunogen. This data suggests that B. thailandensis LPS has the potential to be used as part of a subunit based vaccine against pathogenic B. pseudomallei.

Authors+Show Affiliations

Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20837078

Citation

Ngugi, Sarah A., et al. "Lipopolysaccharide From Burkholderia Thailandensis E264 Provides Protection in a Murine Model of Melioidosis." Vaccine, vol. 28, no. 47, 2010, pp. 7551-5.
Ngugi SA, Ventura VV, Qazi O, et al. Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis. Vaccine. 2010;28(47):7551-5.
Ngugi, S. A., Ventura, V. V., Qazi, O., Harding, S. V., Kitto, G. B., Estes, D. M., Dell, A., Titball, R. W., Atkins, T. P., Brown, K. A., Hitchen, P. G., & Prior, J. L. (2010). Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis. Vaccine, 28(47), 7551-5. https://doi.org/10.1016/j.vaccine.2010.08.058
Ngugi SA, et al. Lipopolysaccharide From Burkholderia Thailandensis E264 Provides Protection in a Murine Model of Melioidosis. Vaccine. 2010 Nov 3;28(47):7551-5. PubMed PMID: 20837078.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis. AU - Ngugi,Sarah A, AU - Ventura,Valeria V, AU - Qazi,Omar, AU - Harding,Sarah V, AU - Kitto,G Barrie, AU - Estes,D Mark, AU - Dell,Anne, AU - Titball,Richard W, AU - Atkins,Timothy P, AU - Brown,Katherine A, AU - Hitchen,Paul G, AU - Prior,Joann L, Y1 - 2010/09/15/ PY - 2010/05/24/received PY - 2010/08/10/revised PY - 2010/08/11/accepted PY - 2010/9/15/entrez PY - 2010/9/15/pubmed PY - 2011/1/19/medline SP - 7551 EP - 5 JF - Vaccine JO - Vaccine VL - 28 IS - 47 N2 - Burkholderia thailandensis is a less virulent close relative of Burkholderia pseudomallei, a CDC category B biothreat agent. We have previously shown that lipopolysaccharide (LPS) extracted from B. pseudomallei can provide protection against a lethal challenge of B. pseudomallei in a mouse model of melioidosis. Sugar analysis on LPS from B. thailandensis strain E264 confirmed that this polysaccharide has a similar structure to LPS from B. pseudomallei. Mice were immunised with LPS from B. thailandensis or B. pseudomallei and challenged with a lethal dose of B. pseudomallei strain K96243. Similar protection levels were observed when either LPS was used as the immunogen. This data suggests that B. thailandensis LPS has the potential to be used as part of a subunit based vaccine against pathogenic B. pseudomallei. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/20837078/Lipopolysaccharide_from_Burkholderia_thailandensis_E264_provides_protection_in_a_murine_model_of_melioidosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(10)01215-6 DB - PRIME DP - Unbound Medicine ER -