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Prenatal and infant exposure to thimerosal from vaccines and immunoglobulins and risk of autism.
Pediatrics. 2010 Oct; 126(4):656-64.Ped

Abstract

OBJECTIVE

Exposure to thimerosal, a mercury-containing preservative that is used in vaccines and immunoglobulin preparations, has been hypothesized to be associated with increased risk of autism spectrum disorder (ASD). This study was designed to examine relationships between prenatal and infant ethylmercury exposure from thimerosal-containing vaccines and/or immunoglobulin preparations and ASD and 2 ASD subcategories: autistic disorder (AD) and ASD with regression.

METHODS

A case-control study was conducted in 3 managed care organizations (MCOs) of 256 children with ASD and 752 controls matched by birth year, gender, and MCO. ASD diagnoses were validated through standardized in-person evaluations. Exposure to thimerosal in vaccines and immunoglobulin preparations was determined from electronic immunization registries, medical charts, and parent interviews. Information on potential confounding factors was obtained from the interviews and medical charts. We used conditional logistic regression to assess associations between ASD, AD, and ASD with regression and exposure to ethylmercury during prenatal, birth-to-1 month, birth-to-7-month, and birth-to-20-month periods.

RESULTS

There were no findings of increased risk for any of the 3 ASD outcomes. The adjusted odds ratios (95% confidence intervals) for ASD associated with a 2-SD increase in ethylmercury exposure were 1.12 (0.83-1.51) for prenatal exposure, 0.88 (0.62-1.26) for exposure from birth to 1 month, 0.60 (0.36-0.99) for exposure from birth to 7 months, and 0.60 (0.32-0.97) for exposure from birth to 20 months.

CONCLUSIONS

In our study of MCO members, prenatal and early-life exposure to ethylmercury from thimerosal-containing vaccines and immunoglobulin preparations was not related to increased risk of ASDs.

Authors+Show Affiliations

Abt Associates Inc., Cambridge, MA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

20837594

Citation

Price, Cristofer S., et al. "Prenatal and Infant Exposure to Thimerosal From Vaccines and Immunoglobulins and Risk of Autism." Pediatrics, vol. 126, no. 4, 2010, pp. 656-64.
Price CS, Thompson WW, Goodson B, et al. Prenatal and infant exposure to thimerosal from vaccines and immunoglobulins and risk of autism. Pediatrics. 2010;126(4):656-64.
Price, C. S., Thompson, W. W., Goodson, B., Weintraub, E. S., Croen, L. A., Hinrichsen, V. L., Marcy, M., Robertson, A., Eriksen, E., Lewis, E., Bernal, P., Shay, D., Davis, R. L., & DeStefano, F. (2010). Prenatal and infant exposure to thimerosal from vaccines and immunoglobulins and risk of autism. Pediatrics, 126(4), 656-64. https://doi.org/10.1542/peds.2010-0309
Price CS, et al. Prenatal and Infant Exposure to Thimerosal From Vaccines and Immunoglobulins and Risk of Autism. Pediatrics. 2010;126(4):656-64. PubMed PMID: 20837594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal and infant exposure to thimerosal from vaccines and immunoglobulins and risk of autism. AU - Price,Cristofer S, AU - Thompson,William W, AU - Goodson,Barbara, AU - Weintraub,Eric S, AU - Croen,Lisa A, AU - Hinrichsen,Virginia L, AU - Marcy,Michael, AU - Robertson,Anne, AU - Eriksen,Eileen, AU - Lewis,Edwin, AU - Bernal,Pilar, AU - Shay,David, AU - Davis,Robert L, AU - DeStefano,Frank, Y1 - 2010/09/13/ PY - 2010/9/15/entrez PY - 2010/9/15/pubmed PY - 2010/10/28/medline SP - 656 EP - 64 JF - Pediatrics JO - Pediatrics VL - 126 IS - 4 N2 - OBJECTIVE: Exposure to thimerosal, a mercury-containing preservative that is used in vaccines and immunoglobulin preparations, has been hypothesized to be associated with increased risk of autism spectrum disorder (ASD). This study was designed to examine relationships between prenatal and infant ethylmercury exposure from thimerosal-containing vaccines and/or immunoglobulin preparations and ASD and 2 ASD subcategories: autistic disorder (AD) and ASD with regression. METHODS: A case-control study was conducted in 3 managed care organizations (MCOs) of 256 children with ASD and 752 controls matched by birth year, gender, and MCO. ASD diagnoses were validated through standardized in-person evaluations. Exposure to thimerosal in vaccines and immunoglobulin preparations was determined from electronic immunization registries, medical charts, and parent interviews. Information on potential confounding factors was obtained from the interviews and medical charts. We used conditional logistic regression to assess associations between ASD, AD, and ASD with regression and exposure to ethylmercury during prenatal, birth-to-1 month, birth-to-7-month, and birth-to-20-month periods. RESULTS: There were no findings of increased risk for any of the 3 ASD outcomes. The adjusted odds ratios (95% confidence intervals) for ASD associated with a 2-SD increase in ethylmercury exposure were 1.12 (0.83-1.51) for prenatal exposure, 0.88 (0.62-1.26) for exposure from birth to 1 month, 0.60 (0.36-0.99) for exposure from birth to 7 months, and 0.60 (0.32-0.97) for exposure from birth to 20 months. CONCLUSIONS: In our study of MCO members, prenatal and early-life exposure to ethylmercury from thimerosal-containing vaccines and immunoglobulin preparations was not related to increased risk of ASDs. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/20837594/Prenatal_and_infant_exposure_to_thimerosal_from_vaccines_and_immunoglobulins_and_risk_of_autism_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=20837594 DB - PRIME DP - Unbound Medicine ER -