Tags

Type your tag names separated by a space and hit enter

Hepatoprotective effects of Sedum sarmentosum on D-galactosamine/lipopolysaccharide-induced murine fulminant hepatic failure.
J Pharmacol Sci 2010; 114(2):147-57JP

Abstract

The hepatoprotective effects of sarmentosin-containing extracts of Sedum sarmentosum (SS) in D-galactosamine (D-GalN) / lipopolysaccharide (LPS)-induced fulminant hepatic failure mouse model. Pretreatment with SS markedly protected mice from lethal liver injury, which has known to be associated with an abrupt elevation of serum tumor necrosis factor (TNF)-α level. Indeed, SS significantly blocked the elevation of TNF-α and alanine aminotransferase and aspartate aminotransferase as well. SS also remarkably reduced number of apoptotic hepatocytes and DNA fragmentation in the liver, which correlated with blockade of caspase-3 activation. In addition, SS suppressed the increased expression of toll-like receptor 4 (TLR4). The activation of c-Jun NH(2)-terminal kinase, extracellular signal-regulated kinase, and p38 induced by D-GalN/LPS was also significantly suppressed by SS treatment. Furthermore, SS significantly inhibited the activation of nuclear factor-κB. In RAW 264.7 cells stimulated with LPS, TNF-α release and TLR4 expression was suppressed by SS pretreatment, which was in line with in vivo results. These findings suggested that SS prevents D-GalN/LPS-induced fulminant hepatic failure, and this protection is likely associated with its anti-apoptotic activity and the down-regulation of mitogen activated protein kinase activity associated at least in part with suppressing the transcription of LPS receptors.

Authors+Show Affiliations

Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20838028

Citation

Lian, Li-Hua, et al. "Hepatoprotective Effects of Sedum Sarmentosum On D-galactosamine/lipopolysaccharide-induced Murine Fulminant Hepatic Failure." Journal of Pharmacological Sciences, vol. 114, no. 2, 2010, pp. 147-57.
Lian LH, Jin X, Wu YL, et al. Hepatoprotective effects of Sedum sarmentosum on D-galactosamine/lipopolysaccharide-induced murine fulminant hepatic failure. J Pharmacol Sci. 2010;114(2):147-57.
Lian, L. H., Jin, X., Wu, Y. L., Cai, X. F., Lee, J. J., & Nan, J. X. (2010). Hepatoprotective effects of Sedum sarmentosum on D-galactosamine/lipopolysaccharide-induced murine fulminant hepatic failure. Journal of Pharmacological Sciences, 114(2), pp. 147-57.
Lian LH, et al. Hepatoprotective Effects of Sedum Sarmentosum On D-galactosamine/lipopolysaccharide-induced Murine Fulminant Hepatic Failure. J Pharmacol Sci. 2010;114(2):147-57. PubMed PMID: 20838028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatoprotective effects of Sedum sarmentosum on D-galactosamine/lipopolysaccharide-induced murine fulminant hepatic failure. AU - Lian,Li-Hua, AU - Jin,Xuejun, AU - Wu,Yan-Ling, AU - Cai,Xing Fu, AU - Lee,Jung Joon, AU - Nan,Ji-Xing, Y1 - 2010/09/11/ PY - 2010/9/15/entrez PY - 2010/9/15/pubmed PY - 2011/2/25/medline SP - 147 EP - 57 JF - Journal of pharmacological sciences JO - J. Pharmacol. Sci. VL - 114 IS - 2 N2 - The hepatoprotective effects of sarmentosin-containing extracts of Sedum sarmentosum (SS) in D-galactosamine (D-GalN) / lipopolysaccharide (LPS)-induced fulminant hepatic failure mouse model. Pretreatment with SS markedly protected mice from lethal liver injury, which has known to be associated with an abrupt elevation of serum tumor necrosis factor (TNF)-α level. Indeed, SS significantly blocked the elevation of TNF-α and alanine aminotransferase and aspartate aminotransferase as well. SS also remarkably reduced number of apoptotic hepatocytes and DNA fragmentation in the liver, which correlated with blockade of caspase-3 activation. In addition, SS suppressed the increased expression of toll-like receptor 4 (TLR4). The activation of c-Jun NH(2)-terminal kinase, extracellular signal-regulated kinase, and p38 induced by D-GalN/LPS was also significantly suppressed by SS treatment. Furthermore, SS significantly inhibited the activation of nuclear factor-κB. In RAW 264.7 cells stimulated with LPS, TNF-α release and TLR4 expression was suppressed by SS pretreatment, which was in line with in vivo results. These findings suggested that SS prevents D-GalN/LPS-induced fulminant hepatic failure, and this protection is likely associated with its anti-apoptotic activity and the down-regulation of mitogen activated protein kinase activity associated at least in part with suppressing the transcription of LPS receptors. SN - 1347-8648 UR - https://www.unboundmedicine.com/medline/citation/20838028/Hepatoprotective_effects_of_Sedum_sarmentosum_on_D_galactosamine/lipopolysaccharide_induced_murine_fulminant_hepatic_failure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/JST.JSTAGE/jphs/10045FP DB - PRIME DP - Unbound Medicine ER -