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[Light-induced damage to the eye].

Abstract

The following review outlines the mechanisms of phototoxicity that are known so far, how they develop, which risk factors are involved, and what the consequences are for ophthalmology. It is necessary to differentiate between photochemical and thermal damage as they differ with regard to etiology and course. Photochemical damage in the lens originates from the absorption of UV-A light; damage caused by oxidation can cause nuclear cataract. Photochemical damage of the retina occurs typically after a longer interval and is mainly due to short-wavelength visible light ("blue light damage"); it entails destruction of membranes of the photoreceptor outer segments and finally photoreceptor death. There are indications that age-related macular degeneration can be accelerated by photochemical light damage. Lipofuscin, photo-sensitizing drugs and prolonged exposure, as well as aphakia and pseudophakia, can increase the risk. Thermal injury is caused mainly by absorption of longer-wavelength light by the retinal pigment epithelium; the effects are usually immediate. The amount of light that can cause threshold damage by common light sources and ophthalmological instruments is given in relation to wavelength, area, and the period of exposure. This information provides the criteria for optimal light-protection glasses. Phototoxic damage can be avoided by awareness, measurement and corresponding action, including the development of better industrial standards for sunglasses and light-emitting devices.

Authors+Show Affiliations

Lehrstuhl und Abteilung für Pathophysiologie des Sehens und Neuroophthalmologie, Universitäts-Augenklinik, Tübingen, Bundesrepublik Deutschland.

Source

MeSH

Eye
Eye Burns
Humans
Lens, Crystalline
Light
Photoreceptor Cells
Radiation Injuries
Retina

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

2083911

Citation

Zrenner, E. "[Light-induced Damage to the Eye]." Fortschritte Der Ophthalmologie : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft, vol. 87 Suppl, 1990, pp. S41-51.
Zrenner E. [Light-induced damage to the eye]. Fortschr Ophthalmol. 1990;87 Suppl:S41-51.
Zrenner, E. (1990). [Light-induced damage to the eye]. Fortschritte Der Ophthalmologie : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft, 87 Suppl, pp. S41-51.
Zrenner E. [Light-induced Damage to the Eye]. Fortschr Ophthalmol. 1990;87 Suppl:S41-51. PubMed PMID: 2083911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Light-induced damage to the eye]. A1 - Zrenner,E, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - S41 EP - 51 JF - Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft JO - Fortschr Ophthalmol VL - 87 Suppl N2 - The following review outlines the mechanisms of phototoxicity that are known so far, how they develop, which risk factors are involved, and what the consequences are for ophthalmology. It is necessary to differentiate between photochemical and thermal damage as they differ with regard to etiology and course. Photochemical damage in the lens originates from the absorption of UV-A light; damage caused by oxidation can cause nuclear cataract. Photochemical damage of the retina occurs typically after a longer interval and is mainly due to short-wavelength visible light ("blue light damage"); it entails destruction of membranes of the photoreceptor outer segments and finally photoreceptor death. There are indications that age-related macular degeneration can be accelerated by photochemical light damage. Lipofuscin, photo-sensitizing drugs and prolonged exposure, as well as aphakia and pseudophakia, can increase the risk. Thermal injury is caused mainly by absorption of longer-wavelength light by the retinal pigment epithelium; the effects are usually immediate. The amount of light that can cause threshold damage by common light sources and ophthalmological instruments is given in relation to wavelength, area, and the period of exposure. This information provides the criteria for optimal light-protection glasses. Phototoxic damage can be avoided by awareness, measurement and corresponding action, including the development of better industrial standards for sunglasses and light-emitting devices. SN - 0723-8045 UR - https://www.unboundmedicine.com/medline/citation/2083911/[Light_induced_damage_to_the_eye]_ L2 - https://medlineplus.gov/eyecare.html DB - PRIME DP - Unbound Medicine ER -