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Chemical composition and antimicrobial activity of the essential oils from Cleome spinosa.
Nat Prod Commun. 2010 Aug; 5(8):1301-6.NP

Abstract

Five different essential oil extractions of the aerial parts of Cleome spinosa Jacq. were examined. The oils obtained by hydrodistillation of the whole aerial parts, aerial parts without flowers (fruit, leaves and stem), flowers, fruits and leaves have been examined by GC-FID and GC-MS. The chemical profiles of the oils reveal the dominance of oxygenated sesqui- and diterpenes, with the exception of the fruit oil, which contained a high content of fatty acids. The most abundant compounds from the whole aerial parts were (Z)-phytol (31.3%), integerrimine (5.5%) and incensole (4.0%). The major compounds from the aerial portion without flowers were caryophyllene oxide (10.5%), (-)-spathulenol (7.5%) and Z-phytol (6.9%). In the flower oil, the main components were 7-alpha-hydroxy manool (23.8%), incensole (9.2%) and sclareol (8.7%). The chief constituents in the fruit oil were tetradecanoic acid (40.6%), (Z)-phytol (6.58%) and sclareol (4.5%). In the leaf oil, (Z)-phytol (19.5%), 7-alpha-hydroxy manool (6.8%) and caryophyllene oxide (4.36%) were the predominant compounds. Antimicrobial activity of the oil obtained from the whole aerial part was evaluated against nine microbial strains using a filter paper disc-diffusion method. The volatile oil showed moderate action against seven of the eight bacteria strains used, with significant inhibitory activity against Streptococcus pyogenes Group A when compared with the standard antibiotics, ampicillin and gentamicin. The fungus, Candida albicans was less sensitive to the essential oil. The oils showed moderate insecticidal activity against Cylas formicarius elegantalus, but possessed no antioxidant activity as indicated by the DPPH method. This represents the first report on the chemical composition of the essential oils from C. spinosa found in Jamaica and the in vitro antioxidant, insecticidal and antimicrobial potential of the oil from the aerial parts.

Authors+Show Affiliations

McNeil MJ
Department of Chemistry, University of the West Indies, Mona, Kingston 7, Jamaica.
Porter RB
No affiliation info available
Williams LA
No affiliation info available
Rainford L
No affiliation info available

MeSH

AnimalsAnti-Infective AgentsAntioxidantsChromatography, GasCleomeGas Chromatography-Mass SpectrometryInsecticidesOils, VolatileWeevils

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20839641

Citation

McNeil, Megil J., et al. "Chemical Composition and Antimicrobial Activity of the Essential Oils From Cleome Spinosa." Natural Product Communications, vol. 5, no. 8, 2010, pp. 1301-6.
McNeil MJ, Porter RB, Williams LA, et al. Chemical composition and antimicrobial activity of the essential oils from Cleome spinosa. Nat Prod Commun. 2010;5(8):1301-6.
McNeil, M. J., Porter, R. B., Williams, L. A., & Rainford, L. (2010). Chemical composition and antimicrobial activity of the essential oils from Cleome spinosa. Natural Product Communications, 5(8), 1301-6.
McNeil MJ, et al. Chemical Composition and Antimicrobial Activity of the Essential Oils From Cleome Spinosa. Nat Prod Commun. 2010;5(8):1301-6. PubMed PMID: 20839641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical composition and antimicrobial activity of the essential oils from Cleome spinosa. AU - McNeil,Megil J, AU - Porter,Roy B R, AU - Williams,Lawrence A D, AU - Rainford,Lois, PY - 2010/9/16/entrez PY - 2010/9/16/pubmed PY - 2010/10/19/medline SP - 1301 EP - 6 JF - Natural product communications JO - Nat Prod Commun VL - 5 IS - 8 N2 - Five different essential oil extractions of the aerial parts of Cleome spinosa Jacq. were examined. The oils obtained by hydrodistillation of the whole aerial parts, aerial parts without flowers (fruit, leaves and stem), flowers, fruits and leaves have been examined by GC-FID and GC-MS. The chemical profiles of the oils reveal the dominance of oxygenated sesqui- and diterpenes, with the exception of the fruit oil, which contained a high content of fatty acids. The most abundant compounds from the whole aerial parts were (Z)-phytol (31.3%), integerrimine (5.5%) and incensole (4.0%). The major compounds from the aerial portion without flowers were caryophyllene oxide (10.5%), (-)-spathulenol (7.5%) and Z-phytol (6.9%). In the flower oil, the main components were 7-alpha-hydroxy manool (23.8%), incensole (9.2%) and sclareol (8.7%). The chief constituents in the fruit oil were tetradecanoic acid (40.6%), (Z)-phytol (6.58%) and sclareol (4.5%). In the leaf oil, (Z)-phytol (19.5%), 7-alpha-hydroxy manool (6.8%) and caryophyllene oxide (4.36%) were the predominant compounds. Antimicrobial activity of the oil obtained from the whole aerial part was evaluated against nine microbial strains using a filter paper disc-diffusion method. The volatile oil showed moderate action against seven of the eight bacteria strains used, with significant inhibitory activity against Streptococcus pyogenes Group A when compared with the standard antibiotics, ampicillin and gentamicin. The fungus, Candida albicans was less sensitive to the essential oil. The oils showed moderate insecticidal activity against Cylas formicarius elegantalus, but possessed no antioxidant activity as indicated by the DPPH method. This represents the first report on the chemical composition of the essential oils from C. spinosa found in Jamaica and the in vitro antioxidant, insecticidal and antimicrobial potential of the oil from the aerial parts. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/20839641/Chemical_composition_and_antimicrobial_activity_of_the_essential_oils_from_Cleome_spinosa_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:20839641 DB - PRIME DP - Unbound Medicine ER -