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Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model.
Life Sci. 2010 Nov 20; 87(19-22):596-603.LS

Abstract

AIM

Epilepsy as well as chronic use of most antiepileptic drugs predisposes to cognitive impairment. Curcumin has been reported to possess antioxidant, anticonvulsant as well as neuroprotective potential. Hence, this study was conducted to evaluate the effect of curcumin against seizures, cognitive impairment and oxidative stress in pentylenetetrazole-induced kindling in rats.

MAIN METHODS

The effect of pretreatment with curcumin (100, 200 and 300 mg/kg, orally) on pentylenetetrazole (PTZ)-induced kindling, kindling-induced cognitive impairment and oxidative stress was evaluated. Male Wistar rats were injected PTZ (30 mg/kg, i.p.) once every alternate day (48±1h) until the development of kindling. Cognitive impairment was assessed using elevated plus maze and passive avoidance test while the oxidative stress parameters (malondialdehyde and glutathione) were estimated in the whole brain at the end of experiments.

KEY FINDINGS

PTZ, 30 mg/kg, induced kindling in rats after 31.0±1.4 days. Curcumin showed dose-dependent anti-seizure effect. Curcumin (300 mg/kg) significantly increased the latency to myoclonic jerks, clonic seizures as well as generalized tonic-clonic seizures, improved the seizure score and decreased the number of myoclonic jerks. PTZ kindling induced a significant oxidative stress and cognitive impairment which was reversed by pretreatment with curcumin in a dose-dependent manner.

SIGNIFICANCE

The results indicate that pretreatment with curcumin ameliorates seizures, oxidative stress and cognitive impairment in PTZ induced kindling in rats. These results thus suggest the potential of curcumin as an adjuvant in epilepsy both to prevent seizures as well as to protect against seizure induced memory impairment.

Authors+Show Affiliations

Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi-110029, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20840851

Citation

Mehla, Jogender, et al. "Protective Effect of Curcumin Against Seizures and Cognitive Impairment in a Pentylenetetrazole-kindled Epileptic Rat Model." Life Sciences, vol. 87, no. 19-22, 2010, pp. 596-603.
Mehla J, Reeta KH, Gupta P, et al. Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. Life Sci. 2010;87(19-22):596-603.
Mehla, J., Reeta, K. H., Gupta, P., & Gupta, Y. K. (2010). Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. Life Sciences, 87(19-22), 596-603. https://doi.org/10.1016/j.lfs.2010.09.006
Mehla J, et al. Protective Effect of Curcumin Against Seizures and Cognitive Impairment in a Pentylenetetrazole-kindled Epileptic Rat Model. Life Sci. 2010 Nov 20;87(19-22):596-603. PubMed PMID: 20840851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. AU - Mehla,Jogender, AU - Reeta,K H, AU - Gupta,Pooja, AU - Gupta,Yogendra Kumar, Y1 - 2010/09/16/ PY - 2010/05/10/received PY - 2010/08/21/revised PY - 2010/09/01/accepted PY - 2010/9/16/entrez PY - 2010/9/16/pubmed PY - 2010/12/14/medline SP - 596 EP - 603 JF - Life sciences JO - Life Sci VL - 87 IS - 19-22 N2 - AIM: Epilepsy as well as chronic use of most antiepileptic drugs predisposes to cognitive impairment. Curcumin has been reported to possess antioxidant, anticonvulsant as well as neuroprotective potential. Hence, this study was conducted to evaluate the effect of curcumin against seizures, cognitive impairment and oxidative stress in pentylenetetrazole-induced kindling in rats. MAIN METHODS: The effect of pretreatment with curcumin (100, 200 and 300 mg/kg, orally) on pentylenetetrazole (PTZ)-induced kindling, kindling-induced cognitive impairment and oxidative stress was evaluated. Male Wistar rats were injected PTZ (30 mg/kg, i.p.) once every alternate day (48±1h) until the development of kindling. Cognitive impairment was assessed using elevated plus maze and passive avoidance test while the oxidative stress parameters (malondialdehyde and glutathione) were estimated in the whole brain at the end of experiments. KEY FINDINGS: PTZ, 30 mg/kg, induced kindling in rats after 31.0±1.4 days. Curcumin showed dose-dependent anti-seizure effect. Curcumin (300 mg/kg) significantly increased the latency to myoclonic jerks, clonic seizures as well as generalized tonic-clonic seizures, improved the seizure score and decreased the number of myoclonic jerks. PTZ kindling induced a significant oxidative stress and cognitive impairment which was reversed by pretreatment with curcumin in a dose-dependent manner. SIGNIFICANCE: The results indicate that pretreatment with curcumin ameliorates seizures, oxidative stress and cognitive impairment in PTZ induced kindling in rats. These results thus suggest the potential of curcumin as an adjuvant in epilepsy both to prevent seizures as well as to protect against seizure induced memory impairment. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/20840851/Protective_effect_of_curcumin_against_seizures_and_cognitive_impairment_in_a_pentylenetetrazole_kindled_epileptic_rat_model_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(10)00381-4 DB - PRIME DP - Unbound Medicine ER -