Tags

Type your tag names separated by a space and hit enter

A comparison of the bioavailability of ferrous fumarate and ferrous sulfate in non-anemic Mexican women and children consuming a sweetened maize and milk drink.
Eur J Clin Nutr. 2011 Jan; 65(1):20-5.EJ

Abstract

BACKGROUND/OBJECTIVES

Ferrous fumarate is recommended for the fortification of complementary foods based on similar iron absorption to ferrous sulfate in adults. Two recent studies in young children have reported that it is only 30% as well absorbed as ferrous sulfate. The objective of this study was to compare iron absorption from ferrous fumarate and ferrous sulfate in infants, young children and mothers.

SUBJECTS/METHODS

Non-anemic Mexican infants (6-24 months), young children (2-5 years) and adult women were randomly assigned to receive either 4 mg Fe (women) or 2.5 mg Fe (infants and young children) as either [(57)Fe]-ferrous fumarate or [(58)Fe]-ferrous sulfate added to a sweetened drink based on degermed maize flour and milk powder. Iron absorption was calculated based on incorporation of isotopes into erythrocytes after 14 days.

RESULTS

Within each population group, no significant differences (P > 0.05) in iron absorption were found between ferrous fumarate and ferrous sulfate. Mean iron absorption from ferrous fumarate vs ferrous sulfate was 17.5 vs 20.5% in women (relative bioavailability (RBV) =86), 7.0 vs 7.2% in infants (RBV = 97) and 6.3 vs 5.9% in young children (RBV = 106).

CONCLUSIONS

Ferrous fumarate is as well absorbed as ferrous sulfate in non-anemic, iron sufficient infants and young children, and can be recommended as a useful fortification compound for complementary foods designed to prevent iron deficiency. Further studies are needed to clarify its usefulness in foods designed to treat iron deficiency.

Links

Aggregator Full Text

Authors+Show Affiliations

Harrington M
Laboratory for Human Nutrition, Swiss Federal Institute of Technology, Zürich, Switzerland.
Hotz C
No affiliation info available
Zeder C
No affiliation info available
Polvo GO
No affiliation info available
Villalpando S
No affiliation info available
Zimmermann MB
No affiliation info available
Walczyk T
No affiliation info available
Rivera JA
No affiliation info available
Hurrell RF
No affiliation info available

MeSH

AdultAnemia, Iron-DeficiencyBeveragesBiological AvailabilityChild, PreschoolDairy ProductsDrug EvaluationFemaleFerrous CompoundsFlourFood, FortifiedHumansInfantIntestinal AbsorptionIronIron, DietaryLinear ModelsMexicoSweetening AgentsZea mays

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20842166

Citation

Harrington, M, et al. "A Comparison of the Bioavailability of Ferrous Fumarate and Ferrous Sulfate in Non-anemic Mexican Women and Children Consuming a Sweetened Maize and Milk Drink." European Journal of Clinical Nutrition, vol. 65, no. 1, 2011, pp. 20-5.
Harrington M, Hotz C, Zeder C, et al. A comparison of the bioavailability of ferrous fumarate and ferrous sulfate in non-anemic Mexican women and children consuming a sweetened maize and milk drink. Eur J Clin Nutr. 2011;65(1):20-5.
Harrington, M., Hotz, C., Zeder, C., Polvo, G. O., Villalpando, S., Zimmermann, M. B., Walczyk, T., Rivera, J. A., & Hurrell, R. F. (2011). A comparison of the bioavailability of ferrous fumarate and ferrous sulfate in non-anemic Mexican women and children consuming a sweetened maize and milk drink. European Journal of Clinical Nutrition, 65(1), 20-5. https://doi.org/10.1038/ejcn.2010.185
Harrington M, et al. A Comparison of the Bioavailability of Ferrous Fumarate and Ferrous Sulfate in Non-anemic Mexican Women and Children Consuming a Sweetened Maize and Milk Drink. Eur J Clin Nutr. 2011;65(1):20-5. PubMed PMID: 20842166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of the bioavailability of ferrous fumarate and ferrous sulfate in non-anemic Mexican women and children consuming a sweetened maize and milk drink. AU - Harrington,M, AU - Hotz,C, AU - Zeder,C, AU - Polvo,G O, AU - Villalpando,S, AU - Zimmermann,M B, AU - Walczyk,T, AU - Rivera,J A, AU - Hurrell,R F, Y1 - 2010/09/15/ PY - 2010/9/16/entrez PY - 2010/9/16/pubmed PY - 2011/4/13/medline SP - 20 EP - 5 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 65 IS - 1 N2 - BACKGROUND/OBJECTIVES: Ferrous fumarate is recommended for the fortification of complementary foods based on similar iron absorption to ferrous sulfate in adults. Two recent studies in young children have reported that it is only 30% as well absorbed as ferrous sulfate. The objective of this study was to compare iron absorption from ferrous fumarate and ferrous sulfate in infants, young children and mothers. SUBJECTS/METHODS: Non-anemic Mexican infants (6-24 months), young children (2-5 years) and adult women were randomly assigned to receive either 4 mg Fe (women) or 2.5 mg Fe (infants and young children) as either [(57)Fe]-ferrous fumarate or [(58)Fe]-ferrous sulfate added to a sweetened drink based on degermed maize flour and milk powder. Iron absorption was calculated based on incorporation of isotopes into erythrocytes after 14 days. RESULTS: Within each population group, no significant differences (P > 0.05) in iron absorption were found between ferrous fumarate and ferrous sulfate. Mean iron absorption from ferrous fumarate vs ferrous sulfate was 17.5 vs 20.5% in women (relative bioavailability (RBV) =86), 7.0 vs 7.2% in infants (RBV = 97) and 6.3 vs 5.9% in young children (RBV = 106). CONCLUSIONS: Ferrous fumarate is as well absorbed as ferrous sulfate in non-anemic, iron sufficient infants and young children, and can be recommended as a useful fortification compound for complementary foods designed to prevent iron deficiency. Further studies are needed to clarify its usefulness in foods designed to treat iron deficiency. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/20842166/A_comparison_of_the_bioavailability_of_ferrous_fumarate_and_ferrous_sulfate_in_non_anemic_Mexican_women_and_children_consuming_a_sweetened_maize_and_milk_drink_ L2 - https://doi.org/10.1038/ejcn.2010.185 DB - PRIME DP - Unbound Medicine ER -