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Quantitative assessment of endoscopic images for degree of villous atrophy in celiac disease.
Dig Dis Sci. 2011 Mar; 56(3):805-11.DD

Abstract

BACKGROUND

The degree of villous atrophy in celiac disease is difficult to assess at endoscopy. We sought to develop a quantitative technique for the evaluation of villous atrophy in endoscopic images.

METHOD

In ten celiac patients as identified by standard endoscopy with biopsy, and ten control patients, standard and videocapsule endoscopic images of the duodenum were digitized. Subimages 7.5 × 7.5 mm(2) in area from random locations within each image were assessed by measuring the length of mucosal fissures per unit area (L), and correlating L with the histologic grade of villous atrophy as determined by modified Marsh criteria.

RESULTS

Mean L values for standard endoscopic images were 37.8, 43.3, 64.1, and 83.5 mm for Marsh grades II, IIIa, IIIb, and IIIc, respectively. Mean L values for videocapsule images were 49.1, 50.0, 64.7, and 72.4 mm for Marsh grades II, IIIa, IIIb, and IIIc, respectively. Significant differences in the means existed between celiac images (Marsh scores II-IIIc) versus controls (p < 0.001) for both endoscopic and videocapsule images. There were no significant differences between measurements obtained from endoscopic versus videocapsule images.

CONCLUSIONS

Quantified image analysis correlates with the histologic grade of villous atrophy, is automated, and lacks observer bias, thus lending itself to standardization.

Authors+Show Affiliations

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA. ciaccio@columbia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20844959

Citation

Ciaccio, Edward J., et al. "Quantitative Assessment of Endoscopic Images for Degree of Villous Atrophy in Celiac Disease." Digestive Diseases and Sciences, vol. 56, no. 3, 2011, pp. 805-11.
Ciaccio EJ, Bhagat G, Tennyson CA, et al. Quantitative assessment of endoscopic images for degree of villous atrophy in celiac disease. Dig Dis Sci. 2011;56(3):805-11.
Ciaccio, E. J., Bhagat, G., Tennyson, C. A., Lewis, S. K., Hernandez, L., & Green, P. H. (2011). Quantitative assessment of endoscopic images for degree of villous atrophy in celiac disease. Digestive Diseases and Sciences, 56(3), 805-11. https://doi.org/10.1007/s10620-010-1371-6
Ciaccio EJ, et al. Quantitative Assessment of Endoscopic Images for Degree of Villous Atrophy in Celiac Disease. Dig Dis Sci. 2011;56(3):805-11. PubMed PMID: 20844959.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative assessment of endoscopic images for degree of villous atrophy in celiac disease. AU - Ciaccio,Edward J, AU - Bhagat,Govind, AU - Tennyson,Christina A, AU - Lewis,Suzanne K, AU - Hernandez,Lincoln, AU - Green,Peter H R, Y1 - 2010/09/16/ PY - 2010/06/10/received PY - 2010/07/26/accepted PY - 2010/9/17/entrez PY - 2010/9/17/pubmed PY - 2011/4/28/medline SP - 805 EP - 11 JF - Digestive diseases and sciences JO - Dig Dis Sci VL - 56 IS - 3 N2 - BACKGROUND: The degree of villous atrophy in celiac disease is difficult to assess at endoscopy. We sought to develop a quantitative technique for the evaluation of villous atrophy in endoscopic images. METHOD: In ten celiac patients as identified by standard endoscopy with biopsy, and ten control patients, standard and videocapsule endoscopic images of the duodenum were digitized. Subimages 7.5 × 7.5 mm(2) in area from random locations within each image were assessed by measuring the length of mucosal fissures per unit area (L), and correlating L with the histologic grade of villous atrophy as determined by modified Marsh criteria. RESULTS: Mean L values for standard endoscopic images were 37.8, 43.3, 64.1, and 83.5 mm for Marsh grades II, IIIa, IIIb, and IIIc, respectively. Mean L values for videocapsule images were 49.1, 50.0, 64.7, and 72.4 mm for Marsh grades II, IIIa, IIIb, and IIIc, respectively. Significant differences in the means existed between celiac images (Marsh scores II-IIIc) versus controls (p < 0.001) for both endoscopic and videocapsule images. There were no significant differences between measurements obtained from endoscopic versus videocapsule images. CONCLUSIONS: Quantified image analysis correlates with the histologic grade of villous atrophy, is automated, and lacks observer bias, thus lending itself to standardization. SN - 1573-2568 UR - https://www.unboundmedicine.com/medline/citation/20844959/Quantitative_assessment_of_endoscopic_images_for_degree_of_villous_atrophy_in_celiac_disease_ L2 - https://doi.org/10.1007/s10620-010-1371-6 DB - PRIME DP - Unbound Medicine ER -