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Anxiolytic effects of a semipurified constituent of guaraná seeds on rats in the elevated T-maze test.
Planta Med. 2011 Feb; 77(3):236-41.PM

Abstract

The objective of this study was to investigate the effects of chronic administration of a semi-purified extract (Purified Extract A--PEA; 4, 8, or 16 mg/kg) of PAULLINIA CUPANA (guaraná) seeds on rats submitted to the elevated T-maze (ETM) model of generalized anxiety and panic disorders. The selective serotonin (5-HT) reuptake inhibitor (SSRI) paroxetine (PAR; 3 mg/kg), was used as a positive control. To evaluate possible serotonergic and dopaminergic neurotransmission involvement in the action of PEA during the ETM test, ineffective doses of metergoline (MET; 5-HT (2A/2C) antagonist receptor) or sulpiride (SUL; dopaminergic receptor antagonist) were acutely administered together with the PEA. The locomotion of the rats was assessed in a circular arena following each drug treatment. Both PEA (8 and 16 mg/kg) and PAR (3 mg/kg) increased one-way escape latencies from the open arm of the ETM, indicating a panicolytic effect compared to the control group. MET, in higher doses (1, 2 or 3 mg/kg), produced a panicolytic effect in the ETM test, whereas SUL did not (10, 20 or 40 mg/kg). The panicolytic effect produced by PEA (8 mg/kg) was blocked by both MET (2 mg/kg) and SUL (20 mg/kg), whereas the panicolytic effect produced by PAR (3 mg/kg) was blocked only by MET (2 mg/kg). These results show that chronic treatment with PEA produces a panicolytic effect during the ETM test, and that the dopaminergic and the serotonergic neurotransmission systems are involved in this effect.

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Authors+Show Affiliations

Roncon CM
Department of Pharmacy and Pharmacology, State University of Maringá, Maringá, PR, Brazil.
Biesdorf de Almeida C
No affiliation info available
Klein T
No affiliation info available
de Mello JC
No affiliation info available
Audi EA
No affiliation info available

MeSH

AnimalsAnti-Anxiety AgentsAnxietyBehavior, AnimalDisease Models, AnimalDopamine AgentsEscape ReactionLocomotionMaleMaze LearningMetergolinePanicParoxetinePaulliniaPhytotherapyPlant ExtractsRatsRats, WistarSeedsSerotonin AgentsSulpiride

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20845263

Citation

Roncon, Camila Marroni, et al. "Anxiolytic Effects of a Semipurified Constituent of Guaraná Seeds On Rats in the Elevated T-maze Test." Planta Medica, vol. 77, no. 3, 2011, pp. 236-41.
Roncon CM, Biesdorf de Almeida C, Klein T, et al. Anxiolytic effects of a semipurified constituent of guaraná seeds on rats in the elevated T-maze test. Planta Med. 2011;77(3):236-41.
Roncon, C. M., Biesdorf de Almeida, C., Klein, T., de Mello, J. C., & Audi, E. A. (2011). Anxiolytic effects of a semipurified constituent of guaraná seeds on rats in the elevated T-maze test. Planta Medica, 77(3), 236-41. https://doi.org/10.1055/s-0030-1250315
Roncon CM, et al. Anxiolytic Effects of a Semipurified Constituent of Guaraná Seeds On Rats in the Elevated T-maze Test. Planta Med. 2011;77(3):236-41. PubMed PMID: 20845263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anxiolytic effects of a semipurified constituent of guaraná seeds on rats in the elevated T-maze test. AU - Roncon,Camila Marroni, AU - Biesdorf de Almeida,Camila, AU - Klein,Traudi, AU - de Mello,João Carlos Palazzo, AU - Audi,Elisabeth Aparecida, Y1 - 2010/09/15/ PY - 2010/9/17/entrez PY - 2010/9/17/pubmed PY - 2011/9/29/medline SP - 236 EP - 41 JF - Planta medica JO - Planta Med VL - 77 IS - 3 N2 - The objective of this study was to investigate the effects of chronic administration of a semi-purified extract (Purified Extract A--PEA; 4, 8, or 16 mg/kg) of PAULLINIA CUPANA (guaraná) seeds on rats submitted to the elevated T-maze (ETM) model of generalized anxiety and panic disorders. The selective serotonin (5-HT) reuptake inhibitor (SSRI) paroxetine (PAR; 3 mg/kg), was used as a positive control. To evaluate possible serotonergic and dopaminergic neurotransmission involvement in the action of PEA during the ETM test, ineffective doses of metergoline (MET; 5-HT (2A/2C) antagonist receptor) or sulpiride (SUL; dopaminergic receptor antagonist) were acutely administered together with the PEA. The locomotion of the rats was assessed in a circular arena following each drug treatment. Both PEA (8 and 16 mg/kg) and PAR (3 mg/kg) increased one-way escape latencies from the open arm of the ETM, indicating a panicolytic effect compared to the control group. MET, in higher doses (1, 2 or 3 mg/kg), produced a panicolytic effect in the ETM test, whereas SUL did not (10, 20 or 40 mg/kg). The panicolytic effect produced by PEA (8 mg/kg) was blocked by both MET (2 mg/kg) and SUL (20 mg/kg), whereas the panicolytic effect produced by PAR (3 mg/kg) was blocked only by MET (2 mg/kg). These results show that chronic treatment with PEA produces a panicolytic effect during the ETM test, and that the dopaminergic and the serotonergic neurotransmission systems are involved in this effect. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/20845263/Anxiolytic_effects_of_a_semipurified_constituent_of_guaraná_seeds_on_rats_in_the_elevated_T_maze_test_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0030-1250315 DB - PRIME DP - Unbound Medicine ER -