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Altered synaptic plasticity and behavioral abnormalities in CNGA3-deficient mice.
Genes Brain Behav 2011; 10(2):137-48GB

Abstract

The role of the cyclic nucleotide-gated (CNG) channel CNGA3 is well established in cone photoreceptors and guanylyl cyclase-D-expressing olfactory neurons. To assess a potential function of CNGA3 in the mouse amygdala and hippocampus, we examined synaptic plasticity and performed a comparative analysis of spatial learning, fear conditioning and step-down avoidance in wild-type mice and CNGA3 null mutants (CNGA3(-/-)). CNGA3(-/-) mice showed normal basal synaptic transmission in the amygdala and the hippocampus. However, cornu Ammonis (CA1) hippocampal long-term potentiation (LTP) induced by a strong tetanus was significantly enhanced in CNGA3(-/-) mice as compared with their wild-type littermates. Unlike in the hippocampus, LTP was not significantly altered in the amygdala of CNGA3(-/-) mice. Enhanced hippocampal LTP did not coincide with changes in hippocampus-dependent learning, as both wild-type and mutant mice showed a similar performance in water maze tasks and contextual fear conditioning, except for a trend toward higher step-down latencies in a passive avoidance task. In contrast, CNGA3(-/-) mice showed markedly reduced freezing to the conditioned tone in the amygdala-dependent cued fear conditioning task. In conclusion, our study adds a new entry on the list of physiological functions of the CNGA3 channel. Despite the dissociation between physiological and behavioral parameters, our data describe a so far unrecognized role of CNGA3 in modulation of hippocampal plasticity and amygdala-dependent fear memory.

Authors+Show Affiliations

Munich Center for Integrated Protein Science, Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians-Universität München, Butenandstrasse 5-13, Munich, Germany. michalakis@lmu.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20846178

Citation

Michalakis, S, et al. "Altered Synaptic Plasticity and Behavioral Abnormalities in CNGA3-deficient Mice." Genes, Brain, and Behavior, vol. 10, no. 2, 2011, pp. 137-48.
Michalakis S, Kleppisch T, Polta SA, et al. Altered synaptic plasticity and behavioral abnormalities in CNGA3-deficient mice. Genes Brain Behav. 2011;10(2):137-48.
Michalakis, S., Kleppisch, T., Polta, S. A., Wotjak, C. T., Koch, S., Rammes, G., ... Biel, M. (2011). Altered synaptic plasticity and behavioral abnormalities in CNGA3-deficient mice. Genes, Brain, and Behavior, 10(2), pp. 137-48. doi:10.1111/j.1601-183X.2010.00646.x.
Michalakis S, et al. Altered Synaptic Plasticity and Behavioral Abnormalities in CNGA3-deficient Mice. Genes Brain Behav. 2011;10(2):137-48. PubMed PMID: 20846178.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Altered synaptic plasticity and behavioral abnormalities in CNGA3-deficient mice. AU - Michalakis,S, AU - Kleppisch,T, AU - Polta,S A, AU - Wotjak,C T, AU - Koch,S, AU - Rammes,G, AU - Matt,L, AU - Becirovic,E, AU - Biel,M, Y1 - 2010/10/07/ PY - 2010/9/18/entrez PY - 2010/9/18/pubmed PY - 2011/6/16/medline SP - 137 EP - 48 JF - Genes, brain, and behavior JO - Genes Brain Behav. VL - 10 IS - 2 N2 - The role of the cyclic nucleotide-gated (CNG) channel CNGA3 is well established in cone photoreceptors and guanylyl cyclase-D-expressing olfactory neurons. To assess a potential function of CNGA3 in the mouse amygdala and hippocampus, we examined synaptic plasticity and performed a comparative analysis of spatial learning, fear conditioning and step-down avoidance in wild-type mice and CNGA3 null mutants (CNGA3(-/-)). CNGA3(-/-) mice showed normal basal synaptic transmission in the amygdala and the hippocampus. However, cornu Ammonis (CA1) hippocampal long-term potentiation (LTP) induced by a strong tetanus was significantly enhanced in CNGA3(-/-) mice as compared with their wild-type littermates. Unlike in the hippocampus, LTP was not significantly altered in the amygdala of CNGA3(-/-) mice. Enhanced hippocampal LTP did not coincide with changes in hippocampus-dependent learning, as both wild-type and mutant mice showed a similar performance in water maze tasks and contextual fear conditioning, except for a trend toward higher step-down latencies in a passive avoidance task. In contrast, CNGA3(-/-) mice showed markedly reduced freezing to the conditioned tone in the amygdala-dependent cued fear conditioning task. In conclusion, our study adds a new entry on the list of physiological functions of the CNGA3 channel. Despite the dissociation between physiological and behavioral parameters, our data describe a so far unrecognized role of CNGA3 in modulation of hippocampal plasticity and amygdala-dependent fear memory. SN - 1601-183X UR - https://www.unboundmedicine.com/medline/citation/20846178/Altered_synaptic_plasticity_and_behavioral_abnormalities_in_CNGA3_deficient_mice_ L2 - https://doi.org/10.1111/j.1601-183X.2010.00646.x DB - PRIME DP - Unbound Medicine ER -