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Differential effect of spironolactone in chronic constriction injury and vincristine-induced neuropathic pain in rats.
Eur J Pharmacol. 2010 Dec 01; 648(1-3):102-9.EJ

Abstract

The present study was designed to investigate the ameliorative potential of spironolactone in chronic constriction injury and vincristine-induced neuropathic pain in rats. The chronic constriction injury was induced by placing four loose ligatures around the sciatic nerve, while vincristine (50 μg/kg) was administered for 10 days to induce chemotherapy-induced neuropathic pain. Acetone drop, pin-prick, hot plate and paint brush tests were performed to assess cold allodynia; mechanical and heat hyperalgesia; dynamic mechanical allodynia, respectively. The spontaneous pain and postural index in terms of foot deformity was also assessed. The levels of TNF-α were measured in the sciatic nerve as an index of inflammation. Chronic constriction injury led to significant development of cold allodynia; mechanical and heat hyperalgesia; dynamic mechanical allodynia; spontaneous pain and foot deformity along with rise in the levels of TNF-α. Administration of vincristine was associated with the development of allodynia and hyperalgesia without spontaneous pain, foot deformity and elevation in the levels of TNF-α. Administration of spironolactone (10 and 20 mg/kg) significantly attenuated chronic constriction injury-induced pain related behaviour and foot deformity along with attenuation of TNF-α levels, without modulating vincristine-induced neuropathic pain. The attenuating effect of spironolactone in chronic constriction injury may be due to its anti-inflammatory properties and ability to decrease pro-inflammatory cytokines, while involvement of non-inflammatory mechanisms in the pathogenesis of vincristine-induced pain may probably explain its lack of beneficial effect in chemotherapy associated pain.

Authors+Show Affiliations

Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala-147002, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20846523

Citation

Jaggi, Amteshwar Singh, and Nirmal Singh. "Differential Effect of Spironolactone in Chronic Constriction Injury and Vincristine-induced Neuropathic Pain in Rats." European Journal of Pharmacology, vol. 648, no. 1-3, 2010, pp. 102-9.
Jaggi AS, Singh N. Differential effect of spironolactone in chronic constriction injury and vincristine-induced neuropathic pain in rats. Eur J Pharmacol. 2010;648(1-3):102-9.
Jaggi, A. S., & Singh, N. (2010). Differential effect of spironolactone in chronic constriction injury and vincristine-induced neuropathic pain in rats. European Journal of Pharmacology, 648(1-3), 102-9. https://doi.org/10.1016/j.ejphar.2010.08.050
Jaggi AS, Singh N. Differential Effect of Spironolactone in Chronic Constriction Injury and Vincristine-induced Neuropathic Pain in Rats. Eur J Pharmacol. 2010 Dec 1;648(1-3):102-9. PubMed PMID: 20846523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential effect of spironolactone in chronic constriction injury and vincristine-induced neuropathic pain in rats. AU - Jaggi,Amteshwar Singh, AU - Singh,Nirmal, Y1 - 2010/09/16/ PY - 2010/07/01/received PY - 2010/08/12/revised PY - 2010/08/31/accepted PY - 2010/9/18/entrez PY - 2010/9/18/pubmed PY - 2011/1/22/medline SP - 102 EP - 9 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 648 IS - 1-3 N2 - The present study was designed to investigate the ameliorative potential of spironolactone in chronic constriction injury and vincristine-induced neuropathic pain in rats. The chronic constriction injury was induced by placing four loose ligatures around the sciatic nerve, while vincristine (50 μg/kg) was administered for 10 days to induce chemotherapy-induced neuropathic pain. Acetone drop, pin-prick, hot plate and paint brush tests were performed to assess cold allodynia; mechanical and heat hyperalgesia; dynamic mechanical allodynia, respectively. The spontaneous pain and postural index in terms of foot deformity was also assessed. The levels of TNF-α were measured in the sciatic nerve as an index of inflammation. Chronic constriction injury led to significant development of cold allodynia; mechanical and heat hyperalgesia; dynamic mechanical allodynia; spontaneous pain and foot deformity along with rise in the levels of TNF-α. Administration of vincristine was associated with the development of allodynia and hyperalgesia without spontaneous pain, foot deformity and elevation in the levels of TNF-α. Administration of spironolactone (10 and 20 mg/kg) significantly attenuated chronic constriction injury-induced pain related behaviour and foot deformity along with attenuation of TNF-α levels, without modulating vincristine-induced neuropathic pain. The attenuating effect of spironolactone in chronic constriction injury may be due to its anti-inflammatory properties and ability to decrease pro-inflammatory cytokines, while involvement of non-inflammatory mechanisms in the pathogenesis of vincristine-induced pain may probably explain its lack of beneficial effect in chemotherapy associated pain. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/20846523/Differential_effect_of_spironolactone_in_chronic_constriction_injury_and_vincristine_induced_neuropathic_pain_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(10)00872-1 DB - PRIME DP - Unbound Medicine ER -