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Mediterranean diet, inflammatory and metabolic biomarkers, and risk of Alzheimer's disease.
J Alzheimers Dis. 2010; 22(2):483-92.JA

Abstract

We aimed to investigate the association between adherence to the Mediterranean diet (MeDi) and Alzheimer's disease (AD) risk in a prospective study. Specifically, we analyzed reduced inflammation and improved metabolic profile as a potential medium through which the MeDi reduced the risk of AD. During a 4-year follow-up, 118 incident AD cases were identified among the 1219 non-demented elderly (age ≥ 65) subjects who provided dietary information and blood samples at baseline. We used high-sensitivity C-reactive protein (hsCRP) as an index of systemic inflammation, and fasting insulin and adiponectin as indexes of metabolic profile. We investigated whether there was a change in the association between MeDi and incident AD risk when the biomarkers were introduced into multivariable adjusted COX models. Better adherence to MeDi was associated with lower level of hsCRP (p =0.003), but not fasting insulin or adiponectin. Better adherence to MeDi was significantly associated with lower risk for AD: compared to those in the lowest tertile of MeDi, subjects in the highest tertile had a 34% less risk of developing AD (p-for-trend =0.04). Introduction of the hsCRP, fasting insulin, adiponectin, or combinations of them into the COX model did not change the magnitude of the association between MeDi and incident AD. Ultimately, the favorable association between better adherence to MeDi and lower risk of AD did not seem to be mediated by hsCRP, fasting insulin, or adiponectin. Other aspects of inflammatory and metabolic pathways not captured by these biomarkers, or non-inflammatory or non-metabolic pathways, may be relevant to the MeDi-AD association.

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Authors+Show Affiliations

Gu Y
Taub Institute for Research of Alzheimer's Disease and Aging Brain, Columbia University, New York, NY, USA.
Luchsinger JA
No affiliation info available
Stern Y
No affiliation info available
Scarmeas N
No affiliation info available

MeSH

AgedAged, 80 and overAlzheimer DiseaseBiomarkersC-Reactive ProteinCognition DisordersCross-Sectional StudiesDiet, MediterraneanFemaleHumansInflammationInsulin ResistanceLongitudinal StudiesMaleRisk Factors

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20847399

Citation

Gu, Yian, et al. "Mediterranean Diet, Inflammatory and Metabolic Biomarkers, and Risk of Alzheimer's Disease." Journal of Alzheimer's Disease : JAD, vol. 22, no. 2, 2010, pp. 483-92.
Gu Y, Luchsinger JA, Stern Y, et al. Mediterranean diet, inflammatory and metabolic biomarkers, and risk of Alzheimer's disease. J Alzheimers Dis. 2010;22(2):483-92.
Gu, Y., Luchsinger, J. A., Stern, Y., & Scarmeas, N. (2010). Mediterranean diet, inflammatory and metabolic biomarkers, and risk of Alzheimer's disease. Journal of Alzheimer's Disease : JAD, 22(2), 483-92. https://doi.org/10.3233/JAD-2010-100897
Gu Y, et al. Mediterranean Diet, Inflammatory and Metabolic Biomarkers, and Risk of Alzheimer's Disease. J Alzheimers Dis. 2010;22(2):483-92. PubMed PMID: 20847399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mediterranean diet, inflammatory and metabolic biomarkers, and risk of Alzheimer's disease. AU - Gu,Yian, AU - Luchsinger,Jose A, AU - Stern,Yaakov, AU - Scarmeas,Nikolaos, PY - 2010/9/18/entrez PY - 2010/9/18/pubmed PY - 2011/3/10/medline SP - 483 EP - 92 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 22 IS - 2 N2 - We aimed to investigate the association between adherence to the Mediterranean diet (MeDi) and Alzheimer's disease (AD) risk in a prospective study. Specifically, we analyzed reduced inflammation and improved metabolic profile as a potential medium through which the MeDi reduced the risk of AD. During a 4-year follow-up, 118 incident AD cases were identified among the 1219 non-demented elderly (age ≥ 65) subjects who provided dietary information and blood samples at baseline. We used high-sensitivity C-reactive protein (hsCRP) as an index of systemic inflammation, and fasting insulin and adiponectin as indexes of metabolic profile. We investigated whether there was a change in the association between MeDi and incident AD risk when the biomarkers were introduced into multivariable adjusted COX models. Better adherence to MeDi was associated with lower level of hsCRP (p =0.003), but not fasting insulin or adiponectin. Better adherence to MeDi was significantly associated with lower risk for AD: compared to those in the lowest tertile of MeDi, subjects in the highest tertile had a 34% less risk of developing AD (p-for-trend =0.04). Introduction of the hsCRP, fasting insulin, adiponectin, or combinations of them into the COX model did not change the magnitude of the association between MeDi and incident AD. Ultimately, the favorable association between better adherence to MeDi and lower risk of AD did not seem to be mediated by hsCRP, fasting insulin, or adiponectin. Other aspects of inflammatory and metabolic pathways not captured by these biomarkers, or non-inflammatory or non-metabolic pathways, may be relevant to the MeDi-AD association. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/20847399/Mediterranean_diet_inflammatory_and_metabolic_biomarkers_and_risk_of_Alzheimer's_disease_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-2010-100897 DB - PRIME DP - Unbound Medicine ER -