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B-vitamins and fatty acids in the prevention and treatment of Alzheimer's disease and dementia: a systematic review.
J Alzheimers Dis 2010; 22(1):205-24JA

Abstract

The increasing worldwide prevalence of dementia is a major public health concern. Findings from some epidemiological studies suggest that diet and nutrition may be important modifiable risk factors for development of dementia. In order to evaluate the strength of the available evidence of an association of dietary factors with dementia including Alzheimer's disease (AD), we systematically searched relevant publication databases and hand-searched bibliographies up to end July 2007. We included prospective cohort studies which evaluated the association of nutrient levels with the risk of developing dementia and randomized intervention studies examining the treatment effect of nutrient supplementation on cognitive function. One hundred and sixty studies, comprising ninety one prospective cohort studies and sixty nine intervention studies, met the pre-specified inclusion criteria. Of these, thirty-three studies (19 cohort and 14 randomized controlled trials) investigated the effects of folate, B-vitamins, and levels of homocysteine (a biomarker modifiable through B-vitamin supplementation) or fish/fatty acids and are the focus of the present report. Some observational cohort studies indicated that higher dietary intake or elevated serum levels of folate and fish/fatty acids and low serum levels of homocysteine were associated with a reduced risk of incident AD and dementia, while other studies reported no association. The results of intervention studies examining the effects of folic acid or fatty acid supplementation on cognitive function are inconsistent. In summary, the available evidence is insufficient to draw definitive conclusions on the association of B vitamins and fatty acids with cognitive decline or dementia, and further long-term trials are required.

Authors+Show Affiliations

Nutrition and Public Health Intervention Research Unit, Department of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK. alan.dangour@lshtm.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

20847412

Citation

Dangour, Alan D., et al. "B-vitamins and Fatty Acids in the Prevention and Treatment of Alzheimer's Disease and Dementia: a Systematic Review." Journal of Alzheimer's Disease : JAD, vol. 22, no. 1, 2010, pp. 205-24.
Dangour AD, Whitehouse PJ, Rafferty K, et al. B-vitamins and fatty acids in the prevention and treatment of Alzheimer's disease and dementia: a systematic review. J Alzheimers Dis. 2010;22(1):205-24.
Dangour, A. D., Whitehouse, P. J., Rafferty, K., Mitchell, S. A., Smith, L., Hawkesworth, S., & Vellas, B. (2010). B-vitamins and fatty acids in the prevention and treatment of Alzheimer's disease and dementia: a systematic review. Journal of Alzheimer's Disease : JAD, 22(1), pp. 205-24. doi:10.3233/JAD-2010-090940.
Dangour AD, et al. B-vitamins and Fatty Acids in the Prevention and Treatment of Alzheimer's Disease and Dementia: a Systematic Review. J Alzheimers Dis. 2010;22(1):205-24. PubMed PMID: 20847412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - B-vitamins and fatty acids in the prevention and treatment of Alzheimer's disease and dementia: a systematic review. AU - Dangour,Alan D, AU - Whitehouse,Peter J, AU - Rafferty,Kevin, AU - Mitchell,Stephen A, AU - Smith,Lesley, AU - Hawkesworth,Sophie, AU - Vellas,Bruno, PY - 2010/9/18/entrez PY - 2010/9/18/pubmed PY - 2011/8/30/medline SP - 205 EP - 24 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 22 IS - 1 N2 - The increasing worldwide prevalence of dementia is a major public health concern. Findings from some epidemiological studies suggest that diet and nutrition may be important modifiable risk factors for development of dementia. In order to evaluate the strength of the available evidence of an association of dietary factors with dementia including Alzheimer's disease (AD), we systematically searched relevant publication databases and hand-searched bibliographies up to end July 2007. We included prospective cohort studies which evaluated the association of nutrient levels with the risk of developing dementia and randomized intervention studies examining the treatment effect of nutrient supplementation on cognitive function. One hundred and sixty studies, comprising ninety one prospective cohort studies and sixty nine intervention studies, met the pre-specified inclusion criteria. Of these, thirty-three studies (19 cohort and 14 randomized controlled trials) investigated the effects of folate, B-vitamins, and levels of homocysteine (a biomarker modifiable through B-vitamin supplementation) or fish/fatty acids and are the focus of the present report. Some observational cohort studies indicated that higher dietary intake or elevated serum levels of folate and fish/fatty acids and low serum levels of homocysteine were associated with a reduced risk of incident AD and dementia, while other studies reported no association. The results of intervention studies examining the effects of folic acid or fatty acid supplementation on cognitive function are inconsistent. In summary, the available evidence is insufficient to draw definitive conclusions on the association of B vitamins and fatty acids with cognitive decline or dementia, and further long-term trials are required. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/20847412/B_vitamins_and_fatty_acids_in_the_prevention_and_treatment_of_Alzheimer's_disease_and_dementia:_a_systematic_review_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-2010-090940 DB - PRIME DP - Unbound Medicine ER -