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FK506 reduces amyloid plaque burden and induces MMP-9 in AβPP/PS1 double transgenic mice.
J Alzheimers Dis. 2010; 22(1):97-105.JA

Abstract

Deposition of amyloid-β peptide (Aβ) and neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD), a neurodegenerative disease characterized by cognitive deficits and neuronal loss. Recently, calcineurin (CaN) has been reported as a potential modulator of memory function, synaptic plasticity, and neural degeneration in brains of AD animal models. In the present study, we examined the relationship between Aβ accumulations and CaN activity in brains of the AβPP/PS1 double transgenic mice. Treatment with FK506, a CaN inhibitor, significantly reduces Aβ burden and restores synaptic proteins (synaptophysin and postsynaptic density protein-95; PSD-95) while inducing matrix metallopeptidase-9 (MMP-9) expression in GFAP-positive astrocytes in the brain. These results suggest a role of FK506 and control of CaN activity in neuroprotection associated with Aβ deposition in AD.

Authors+Show Affiliations

Department of Biochemistry and Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20847451

Citation

Hong, Hyun-Seok, et al. "FK506 Reduces Amyloid Plaque Burden and Induces MMP-9 in AβPP/PS1 Double Transgenic Mice." Journal of Alzheimer's Disease : JAD, vol. 22, no. 1, 2010, pp. 97-105.
Hong HS, Hwang JY, Son SM, et al. FK506 reduces amyloid plaque burden and induces MMP-9 in AβPP/PS1 double transgenic mice. J Alzheimers Dis. 2010;22(1):97-105.
Hong, H. S., Hwang, J. Y., Son, S. M., Kim, Y. H., Moon, M., & Inhee, M. J. (2010). FK506 reduces amyloid plaque burden and induces MMP-9 in AβPP/PS1 double transgenic mice. Journal of Alzheimer's Disease : JAD, 22(1), 97-105. https://doi.org/10.3233/JAD-2010-100261
Hong HS, et al. FK506 Reduces Amyloid Plaque Burden and Induces MMP-9 in AβPP/PS1 Double Transgenic Mice. J Alzheimers Dis. 2010;22(1):97-105. PubMed PMID: 20847451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - FK506 reduces amyloid plaque burden and induces MMP-9 in AβPP/PS1 double transgenic mice. AU - Hong,Hyun-Seok, AU - Hwang,Ji-Yeon, AU - Son,Sung-Min, AU - Kim,Yoon-Hee, AU - Moon,Minho, AU - Inhee,Mook-Jung, PY - 2010/9/18/entrez PY - 2010/9/18/pubmed PY - 2011/8/30/medline SP - 97 EP - 105 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 22 IS - 1 N2 - Deposition of amyloid-β peptide (Aβ) and neurofibrillary tangles are pathological hallmarks of Alzheimer's disease (AD), a neurodegenerative disease characterized by cognitive deficits and neuronal loss. Recently, calcineurin (CaN) has been reported as a potential modulator of memory function, synaptic plasticity, and neural degeneration in brains of AD animal models. In the present study, we examined the relationship between Aβ accumulations and CaN activity in brains of the AβPP/PS1 double transgenic mice. Treatment with FK506, a CaN inhibitor, significantly reduces Aβ burden and restores synaptic proteins (synaptophysin and postsynaptic density protein-95; PSD-95) while inducing matrix metallopeptidase-9 (MMP-9) expression in GFAP-positive astrocytes in the brain. These results suggest a role of FK506 and control of CaN activity in neuroprotection associated with Aβ deposition in AD. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/20847451/FK506_reduces_amyloid_plaque_burden_and_induces_MMP_9_in_AβPP/PS1_double_transgenic_mice_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-2010-100261 DB - PRIME DP - Unbound Medicine ER -