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Midlife smoking, apolipoprotein E and risk of dementia and Alzheimer's disease: a population-based cardiovascular risk factors, aging and dementia study.
Dement Geriatr Cogn Disord 2010; 30(3):277-84DG

Abstract

AIM

To elucidate the effect of midlife smoking on the risk of dementia and Alzheimer's disease (AD), and the possible modification of this relation by the apolipoprotein E (APOE) ε4.

METHODS

Participants of the Cardiovascular Risk Factors, Aging and Dementia study were randomly selected from population-based samples originally studied in midlife (1972, 1977, 1982 or 1988). After an average follow-up of 21 years, 1,449 persons (73%) aged 65-79 years took part in a reexamination in 1998.

RESULTS

Smoking in midlife increased the risk of dementia (odds ratio, OR: 4.93; 95% CI: 1.51-16.11) and AD (OR: 6.56; 95% CI: 1.80-23.94) among the APOE ε4 carriers, but not among the APOE ε4 noncarriers.

CONCLUSION

Midlife smoking was associated with an increased risk of dementia and AD later in life only among those individuals carrying the APOE ε4 allele. These results suggest that the association between smoking and AD may be complex and vary according to genotype.

Authors+Show Affiliations

Department of Neurology, University of Eastern Finland, Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20847559

Citation

Rusanen, M, et al. "Midlife Smoking, Apolipoprotein E and Risk of Dementia and Alzheimer's Disease: a Population-based Cardiovascular Risk Factors, Aging and Dementia Study." Dementia and Geriatric Cognitive Disorders, vol. 30, no. 3, 2010, pp. 277-84.
Rusanen M, Rovio S, Ngandu T, et al. Midlife smoking, apolipoprotein E and risk of dementia and Alzheimer's disease: a population-based cardiovascular risk factors, aging and dementia study. Dement Geriatr Cogn Disord. 2010;30(3):277-84.
Rusanen, M., Rovio, S., Ngandu, T., Nissinen, A., Tuomilehto, J., Soininen, H., & Kivipelto, M. (2010). Midlife smoking, apolipoprotein E and risk of dementia and Alzheimer's disease: a population-based cardiovascular risk factors, aging and dementia study. Dementia and Geriatric Cognitive Disorders, 30(3), pp. 277-84. doi:10.1159/000320484.
Rusanen M, et al. Midlife Smoking, Apolipoprotein E and Risk of Dementia and Alzheimer's Disease: a Population-based Cardiovascular Risk Factors, Aging and Dementia Study. Dement Geriatr Cogn Disord. 2010;30(3):277-84. PubMed PMID: 20847559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Midlife smoking, apolipoprotein E and risk of dementia and Alzheimer's disease: a population-based cardiovascular risk factors, aging and dementia study. AU - Rusanen,M, AU - Rovio,S, AU - Ngandu,T, AU - Nissinen,A, AU - Tuomilehto,J, AU - Soininen,H, AU - Kivipelto,M, Y1 - 2010/09/20/ PY - 2010/08/20/accepted PY - 2010/9/18/entrez PY - 2010/9/18/pubmed PY - 2011/1/22/medline SP - 277 EP - 84 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 30 IS - 3 N2 - AIM: To elucidate the effect of midlife smoking on the risk of dementia and Alzheimer's disease (AD), and the possible modification of this relation by the apolipoprotein E (APOE) ε4. METHODS: Participants of the Cardiovascular Risk Factors, Aging and Dementia study were randomly selected from population-based samples originally studied in midlife (1972, 1977, 1982 or 1988). After an average follow-up of 21 years, 1,449 persons (73%) aged 65-79 years took part in a reexamination in 1998. RESULTS: Smoking in midlife increased the risk of dementia (odds ratio, OR: 4.93; 95% CI: 1.51-16.11) and AD (OR: 6.56; 95% CI: 1.80-23.94) among the APOE ε4 carriers, but not among the APOE ε4 noncarriers. CONCLUSION: Midlife smoking was associated with an increased risk of dementia and AD later in life only among those individuals carrying the APOE ε4 allele. These results suggest that the association between smoking and AD may be complex and vary according to genotype. SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/20847559/Midlife_smoking_apolipoprotein_E_and_risk_of_dementia_and_Alzheimer's_disease:_a_population_based_cardiovascular_risk_factors_aging_and_dementia_study_ L2 - https://www.karger.com?DOI=10.1159/000320484 DB - PRIME DP - Unbound Medicine ER -