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Melioidosis: advances in diagnosis and treatment.
Curr Opin Infect Dis. 2010 Dec; 23(6):554-9.CO

Abstract

PURPOSE OF REVIEW

Melioidosis is an infectious disease caused by the soil-associated Gram-negative bacterium Burkholderia pseudomallei. This review summarizes the evidence underlying current antibiotic regimens and discusses future strategies to reduce mortality.

RECENT FINDINGS

Although simple rapid diagnostics exist, they rely on the availability of direct specimen and are not commercially available. Serological tests and nucleic acid detection are not sufficiently specific or sensitive for routine clinical use. Since the original trials defining setting the standard of care as ceftazidime, no antibiotic regimens have been shown to be superior in comparative trials, but ongoing trials are evaluating the efficacy of meropenem (in intensive treatment) and (TMP-SMX) (for eradication treatment).

SUMMARY

In endemic areas, empiric antibiotics should include agents active against melioidosis as well as the other common causes of severe sepsis. It is likely that future improvements in mortality will be the result of efforts to improve on the early recognition and management of severe sepsis generally.

Authors+Show Affiliations

Department of Epidemiology and Preventive Medicine, Monash University, Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia. allen.cheng@monash.edu.au

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20847695

Citation

Cheng, Allen C.. "Melioidosis: Advances in Diagnosis and Treatment." Current Opinion in Infectious Diseases, vol. 23, no. 6, 2010, pp. 554-9.
Cheng AC. Melioidosis: advances in diagnosis and treatment. Curr Opin Infect Dis. 2010;23(6):554-9.
Cheng, A. C. (2010). Melioidosis: advances in diagnosis and treatment. Current Opinion in Infectious Diseases, 23(6), 554-9. https://doi.org/10.1097/QCO.0b013e32833fb88c
Cheng AC. Melioidosis: Advances in Diagnosis and Treatment. Curr Opin Infect Dis. 2010;23(6):554-9. PubMed PMID: 20847695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melioidosis: advances in diagnosis and treatment. A1 - Cheng,Allen C, PY - 2010/9/18/entrez PY - 2010/9/18/pubmed PY - 2011/4/19/medline SP - 554 EP - 9 JF - Current opinion in infectious diseases JO - Curr. Opin. Infect. Dis. VL - 23 IS - 6 N2 - PURPOSE OF REVIEW: Melioidosis is an infectious disease caused by the soil-associated Gram-negative bacterium Burkholderia pseudomallei. This review summarizes the evidence underlying current antibiotic regimens and discusses future strategies to reduce mortality. RECENT FINDINGS: Although simple rapid diagnostics exist, they rely on the availability of direct specimen and are not commercially available. Serological tests and nucleic acid detection are not sufficiently specific or sensitive for routine clinical use. Since the original trials defining setting the standard of care as ceftazidime, no antibiotic regimens have been shown to be superior in comparative trials, but ongoing trials are evaluating the efficacy of meropenem (in intensive treatment) and (TMP-SMX) (for eradication treatment). SUMMARY: In endemic areas, empiric antibiotics should include agents active against melioidosis as well as the other common causes of severe sepsis. It is likely that future improvements in mortality will be the result of efforts to improve on the early recognition and management of severe sepsis generally. SN - 1473-6527 UR - https://www.unboundmedicine.com/medline/citation/20847695/Melioidosis:_advances_in_diagnosis_and_treatment_ L2 - http://dx.doi.org/10.1097/QCO.0b013e32833fb88c DB - PRIME DP - Unbound Medicine ER -