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[Studies about the level of CD4+ CD25+ regulatory T cells and relation between expression of Foxp3 and CD127 in peripheral blood of chronic HBV infection].

Abstract

OBJECTIVE

To investigate the level of CD4+ CD25+ Foxp3+ regulatory T cells and observe relation between expression of Foxp3 and CD127 in peripheral blood of chronic HBV infection.

METHODS

CD4+ CD25+ Foxp3+ and CD4+ CD25+ CD127low Treg in peripheral blood from 34 patients of immune tolerance stage, 26 patients of immune clearance stage and 31 patients of non-active status were quantitatively analyzed by flow cytometry.

RESULTS

Immune tolerance group presented a higher fraction of CD4+ CD25+ Foxp3+ and CD4+ CD25+ CD127low Treg than non-active group in chronic HBV infection (Z = -2.693, P = 0.007 and t = 3.251, P = 0.002), and HBV positive group also presented a higher fraction than non-active group (t = 2.266, P = 0.026 and t = 3.208, P = 0.002), But ALT normal group is similar to ALT abnormal group (P > 0.05). In this study, the relation between expression of CD127low and Foxp3+ from CD4+ CD25+ regulatory T cells was observed, and CD4+ CD25+ CD127low Treg presented a higher fraction than CD4+ CD25+ Foxp3+ Treg.

CONCLUSION

Peripheral Treg in HBV active replication group is higher than HBV negative group of chronic HBV infection. Expression of CD127low is consistent with Foxp3+ in CD4+ CD25+ regulatory T cells, but the former is significantly higher than the latter.

Authors+Show Affiliations

Department of Infectious Diseases, The first Affiliated Hospital of Nanchang University, Nanchang 330006, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

20848841

Citation

Deng, Min, et al. "[Studies About the Level of CD4+ CD25+ Regulatory T Cells and Relation Between Expression of Foxp3 and CD127 in Peripheral Blood of Chronic HBV Infection]." Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology, vol. 24, no. 1, 2010, pp. 21-3.
Deng M, Li MH, Liu SA, et al. [Studies about the level of CD4+ CD25+ regulatory T cells and relation between expression of Foxp3 and CD127 in peripheral blood of chronic HBV infection]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010;24(1):21-3.
Deng, M., Li, M. H., Liu, S. A., Liu, F., Sang, Y., Song, S. J., Zang, S. F., Guan, X. P., Yao, X., Wu, X. P., Cheng, J., & Xu, D. Z. (2010). [Studies about the level of CD4+ CD25+ regulatory T cells and relation between expression of Foxp3 and CD127 in peripheral blood of chronic HBV infection]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology, 24(1), 21-3.
Deng M, et al. [Studies About the Level of CD4+ CD25+ Regulatory T Cells and Relation Between Expression of Foxp3 and CD127 in Peripheral Blood of Chronic HBV Infection]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010;24(1):21-3. PubMed PMID: 20848841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Studies about the level of CD4+ CD25+ regulatory T cells and relation between expression of Foxp3 and CD127 in peripheral blood of chronic HBV infection]. AU - Deng,Min, AU - Li,Ming-Hui, AU - Liu,Shun-Ai, AU - Liu,Feng, AU - Sang,Yan, AU - Song,Shu-Jing, AU - Zang,Shu-Feng, AU - Guan,Xiao-Ping, AU - Yao,Xie, AU - Wu,Xiao-Ping, AU - Cheng,Jun, AU - Xu,Dao-Zhen, PY - 2010/9/21/entrez PY - 2010/9/21/pubmed PY - 2010/10/6/medline SP - 21 EP - 3 JF - Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology JO - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi VL - 24 IS - 1 N2 - OBJECTIVE: To investigate the level of CD4+ CD25+ Foxp3+ regulatory T cells and observe relation between expression of Foxp3 and CD127 in peripheral blood of chronic HBV infection. METHODS: CD4+ CD25+ Foxp3+ and CD4+ CD25+ CD127low Treg in peripheral blood from 34 patients of immune tolerance stage, 26 patients of immune clearance stage and 31 patients of non-active status were quantitatively analyzed by flow cytometry. RESULTS: Immune tolerance group presented a higher fraction of CD4+ CD25+ Foxp3+ and CD4+ CD25+ CD127low Treg than non-active group in chronic HBV infection (Z = -2.693, P = 0.007 and t = 3.251, P = 0.002), and HBV positive group also presented a higher fraction than non-active group (t = 2.266, P = 0.026 and t = 3.208, P = 0.002), But ALT normal group is similar to ALT abnormal group (P > 0.05). In this study, the relation between expression of CD127low and Foxp3+ from CD4+ CD25+ regulatory T cells was observed, and CD4+ CD25+ CD127low Treg presented a higher fraction than CD4+ CD25+ Foxp3+ Treg. CONCLUSION: Peripheral Treg in HBV active replication group is higher than HBV negative group of chronic HBV infection. Expression of CD127low is consistent with Foxp3+ in CD4+ CD25+ regulatory T cells, but the former is significantly higher than the latter. SN - 1003-9279 UR - https://www.unboundmedicine.com/medline/citation/20848841/[Studies_about_the_level_of_CD4+_CD25+_regulatory_T_cells_and_relation_between_expression_of_Foxp3_and_CD127_in_peripheral_blood_of_chronic_HBV_infection]_ DB - PRIME DP - Unbound Medicine ER -