Tags

Type your tag names separated by a space and hit enter

More CLEC16A gene variants associated with multiple sclerosis.
Acta Neurol Scand 2011; 123(6):400-6AN

Abstract

OBJECTIVES

Recently, associations of several single-nucleotide polymorphisms (SNPs) within the CLEC16A gene with multiple sclerosis (MS), type-I diabetes, and primary adrenal insufficiency were reported.

METHODS

We performed linkage disequilibrium (LD) fine mapping with 31 SNPs from this gene, searching for the region of highest association with MS in a German sample consisting of 603 patients and 825 controls.

RESULTS

Four SNPs located in intron 19 of the CLEC16A gene were found associated. We could replicate the finding for SNP rs725613 and were able to show for the first time the association of rs2041670, rs2080272 and rs998592 with MS.

CONCLUSION

All described base polymorphisms are mapping to one LD block of approximately 50 kb within intron 19 of the CLEC16A gene, suggesting a pivotal role of this region for susceptibility of MS and possibly also for other autoimmune diseases.

Authors+Show Affiliations

Max Planck Institute of Psychiatry, Munich, Germany. slutz@mpipsykl.mpg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20849399

Citation

Nischwitz, S, et al. "More CLEC16A Gene Variants Associated With Multiple Sclerosis." Acta Neurologica Scandinavica, vol. 123, no. 6, 2011, pp. 400-6.
Nischwitz S, Cepok S, Kroner A, et al. More CLEC16A gene variants associated with multiple sclerosis. Acta Neurol Scand. 2011;123(6):400-6.
Nischwitz, S., Cepok, S., Kroner, A., Wolf, C., Knop, M., Müller-Sarnowski, F., ... Weber, F. (2011). More CLEC16A gene variants associated with multiple sclerosis. Acta Neurologica Scandinavica, 123(6), pp. 400-6. doi:10.1111/j.1600-0404.2010.01421.x.
Nischwitz S, et al. More CLEC16A Gene Variants Associated With Multiple Sclerosis. Acta Neurol Scand. 2011;123(6):400-6. PubMed PMID: 20849399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - More CLEC16A gene variants associated with multiple sclerosis. AU - Nischwitz,S, AU - Cepok,S, AU - Kroner,A, AU - Wolf,C, AU - Knop,M, AU - Müller-Sarnowski,F, AU - Pfister,H, AU - Rieckmann,P, AU - Hemmer,B, AU - Ising,M, AU - Uhr,M, AU - Bettecken,T, AU - Holsboer,F, AU - Müller-Myhsok,B, AU - Weber,F, Y1 - 2010/09/16/ PY - 2010/9/21/entrez PY - 2010/9/21/pubmed PY - 2012/3/16/medline SP - 400 EP - 6 JF - Acta neurologica Scandinavica JO - Acta Neurol. Scand. VL - 123 IS - 6 N2 - OBJECTIVES: Recently, associations of several single-nucleotide polymorphisms (SNPs) within the CLEC16A gene with multiple sclerosis (MS), type-I diabetes, and primary adrenal insufficiency were reported. METHODS: We performed linkage disequilibrium (LD) fine mapping with 31 SNPs from this gene, searching for the region of highest association with MS in a German sample consisting of 603 patients and 825 controls. RESULTS: Four SNPs located in intron 19 of the CLEC16A gene were found associated. We could replicate the finding for SNP rs725613 and were able to show for the first time the association of rs2041670, rs2080272 and rs998592 with MS. CONCLUSION: All described base polymorphisms are mapping to one LD block of approximately 50 kb within intron 19 of the CLEC16A gene, suggesting a pivotal role of this region for susceptibility of MS and possibly also for other autoimmune diseases. SN - 1600-0404 UR - https://www.unboundmedicine.com/medline/citation/20849399/More_CLEC16A_gene_variants_associated_with_multiple_sclerosis_ L2 - https://doi.org/10.1111/j.1600-0404.2010.01421.x DB - PRIME DP - Unbound Medicine ER -