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The content of docosahexaenoic acid in serum phospholipid is inversely correlated with plasma homocysteine levels in patients with end-stage renal disease.
Nutr Res. 2010 Aug; 30(8):535-40.NR

Abstract

Patients with end-stage renal disease (ESRD) have a high morbidity and mortality from cardiovascular disease. An elevated homocysteine level is an independent predictor of cardiovascular events in patients with ESRD. Interestingly, some studies have found an inverse relationship between the content of marine n-3 polyunsaturated fatty acids (PUFAs) and homocysteine levels, but data are ambiguous. In patients with ESRD, we hypothesized that serum phospholipid n-3 PUFA content would inversely correlate with homocysteine levels in plasma and that supplementation with n-3 PUFA would reduce plasma homocysteine levels. In a double-blind, randomized, controlled design, 206 patients with documented cardiovascular disease and treated with hemodialysis for a minimum of 6 months were randomized to treatment with daily supplement of 1.7 g n-3 PUFA or placebo (olive oil) for 3 months. The content of n-3 PUFA in serum phospholipids and homocysteine levels in plasma were measured at baseline and after 3 months of intervention. A dietary questionnaire was filled out at baseline, and study participants were divided into groups of low, intermediate, and high fish intake. Docosahexaenoic acid was inversely correlated with homocysteine at baseline (coefficient = -0.161; P = .03). Homocysteine was not related to self-reported fish intake. Supplementation with n-3 PUFA did not reduce homocysteine levels compared with placebo (mean ± SD difference, -0.3 ± 7.8 versus 0.3 ± 7.1; P = .58). The content of docosahexaenoic acid in serum phospholipids is inversely correlated with plasma homocysteine levels, and supplementation with n-3 PUFA does not reduce homocysteine levels in patients with ESRD.

Authors+Show Affiliations

Department of Nephrology, Aalborg Hospital, Aarhus University Hospital, 9000 Aalborg, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20851307

Citation

Rasmussen, Lars E., et al. "The Content of Docosahexaenoic Acid in Serum Phospholipid Is Inversely Correlated With Plasma Homocysteine Levels in Patients With End-stage Renal Disease." Nutrition Research (New York, N.Y.), vol. 30, no. 8, 2010, pp. 535-40.
Rasmussen LE, Svensson M, Jørgensen KA, et al. The content of docosahexaenoic acid in serum phospholipid is inversely correlated with plasma homocysteine levels in patients with end-stage renal disease. Nutr Res. 2010;30(8):535-40.
Rasmussen, L. E., Svensson, M., Jørgensen, K. A., Schmidt, E. B., & Christensen, J. H. (2010). The content of docosahexaenoic acid in serum phospholipid is inversely correlated with plasma homocysteine levels in patients with end-stage renal disease. Nutrition Research (New York, N.Y.), 30(8), 535-40. https://doi.org/10.1016/j.nutres.2010.07.004
Rasmussen LE, et al. The Content of Docosahexaenoic Acid in Serum Phospholipid Is Inversely Correlated With Plasma Homocysteine Levels in Patients With End-stage Renal Disease. Nutr Res. 2010;30(8):535-40. PubMed PMID: 20851307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The content of docosahexaenoic acid in serum phospholipid is inversely correlated with plasma homocysteine levels in patients with end-stage renal disease. AU - Rasmussen,Lars E, AU - Svensson,My, AU - Jørgensen,Kaj A, AU - Schmidt,Erik B, AU - Christensen,Jeppe H, PY - 2010/06/09/received PY - 2010/07/12/revised PY - 2010/07/12/accepted PY - 2010/9/21/entrez PY - 2010/9/21/pubmed PY - 2011/2/1/medline SP - 535 EP - 40 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 30 IS - 8 N2 - Patients with end-stage renal disease (ESRD) have a high morbidity and mortality from cardiovascular disease. An elevated homocysteine level is an independent predictor of cardiovascular events in patients with ESRD. Interestingly, some studies have found an inverse relationship between the content of marine n-3 polyunsaturated fatty acids (PUFAs) and homocysteine levels, but data are ambiguous. In patients with ESRD, we hypothesized that serum phospholipid n-3 PUFA content would inversely correlate with homocysteine levels in plasma and that supplementation with n-3 PUFA would reduce plasma homocysteine levels. In a double-blind, randomized, controlled design, 206 patients with documented cardiovascular disease and treated with hemodialysis for a minimum of 6 months were randomized to treatment with daily supplement of 1.7 g n-3 PUFA or placebo (olive oil) for 3 months. The content of n-3 PUFA in serum phospholipids and homocysteine levels in plasma were measured at baseline and after 3 months of intervention. A dietary questionnaire was filled out at baseline, and study participants were divided into groups of low, intermediate, and high fish intake. Docosahexaenoic acid was inversely correlated with homocysteine at baseline (coefficient = -0.161; P = .03). Homocysteine was not related to self-reported fish intake. Supplementation with n-3 PUFA did not reduce homocysteine levels compared with placebo (mean ± SD difference, -0.3 ± 7.8 versus 0.3 ± 7.1; P = .58). The content of docosahexaenoic acid in serum phospholipids is inversely correlated with plasma homocysteine levels, and supplementation with n-3 PUFA does not reduce homocysteine levels in patients with ESRD. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/20851307/The_content_of_docosahexaenoic_acid_in_serum_phospholipid_is_inversely_correlated_with_plasma_homocysteine_levels_in_patients_with_end_stage_renal_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(10)00134-X DB - PRIME DP - Unbound Medicine ER -