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Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different Cinnamon barks.
Phytomedicine. 2011 Feb 15; 18(4):298-302.P

Abstract

Procyanidin oligomers in Cinnamon are thought to be responsible for the biological activity in the treatment of diabetes mellitus (DM). To clarify types of procyanidin oligomers in different Cinnamon species and investigate their different effects, the present study investigated procyanidin oligomers in polyphenolic oligomer-rich extracts of three Cinnamon samples by LC-MS methods, and their hypoglycemic activities were detected in vivo and in vitro. The results showed that two of the three samples from Cinnamomum cassia were rich in B-type procyanidin oligomers, and the other sample was rich in A-type procyanidin oligomers. The Cinnamon extracts were administered at doses of 200 and 300 mg/kg body wt. in high-fat diet-fed and low-dose streptozotocin (STZ)-induced diabetic mice for 14 days. The results showed that blood glucose concentrations were significantly decreased in all Cinnamon extract groups compared with the control group (p<0.05). Administration of the Cinnamon extracts significantly increased the consumption of extracellular glucose in insulin-resistant HepG2 cells and normal HepG2 cells compared with the control group. These results suggest that both A- and B-type procyanidin oligomers in different Cinnamon species have hypoglycemic activities and may improve insulin sensitivity in type 2 DM.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, Second Military Medicinal University, Shanghai 200433, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20851586

Citation

Lu, Zhaolian, et al. "Hypoglycemic Activities of A- and B-type Procyanidin Oligomer-rich Extracts From Different Cinnamon Barks." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 18, no. 4, 2011, pp. 298-302.
Lu Z, Jia Q, Wang R, et al. Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different Cinnamon barks. Phytomedicine. 2011;18(4):298-302.
Lu, Z., Jia, Q., Wang, R., Wu, X., Wu, Y., Huang, C., & Li, Y. (2011). Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different Cinnamon barks. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 18(4), 298-302. https://doi.org/10.1016/j.phymed.2010.08.008
Lu Z, et al. Hypoglycemic Activities of A- and B-type Procyanidin Oligomer-rich Extracts From Different Cinnamon Barks. Phytomedicine. 2011 Feb 15;18(4):298-302. PubMed PMID: 20851586.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different Cinnamon barks. AU - Lu,Zhaolian, AU - Jia,Qi, AU - Wang,Rui, AU - Wu,Ximin, AU - Wu,Yingchun, AU - Huang,Caiguo, AU - Li,Yiming, Y1 - 2010/09/18/ PY - 2010/03/23/received PY - 2010/07/03/revised PY - 2010/08/11/accepted PY - 2010/9/21/entrez PY - 2010/9/21/pubmed PY - 2012/3/28/medline SP - 298 EP - 302 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 18 IS - 4 N2 - Procyanidin oligomers in Cinnamon are thought to be responsible for the biological activity in the treatment of diabetes mellitus (DM). To clarify types of procyanidin oligomers in different Cinnamon species and investigate their different effects, the present study investigated procyanidin oligomers in polyphenolic oligomer-rich extracts of three Cinnamon samples by LC-MS methods, and their hypoglycemic activities were detected in vivo and in vitro. The results showed that two of the three samples from Cinnamomum cassia were rich in B-type procyanidin oligomers, and the other sample was rich in A-type procyanidin oligomers. The Cinnamon extracts were administered at doses of 200 and 300 mg/kg body wt. in high-fat diet-fed and low-dose streptozotocin (STZ)-induced diabetic mice for 14 days. The results showed that blood glucose concentrations were significantly decreased in all Cinnamon extract groups compared with the control group (p<0.05). Administration of the Cinnamon extracts significantly increased the consumption of extracellular glucose in insulin-resistant HepG2 cells and normal HepG2 cells compared with the control group. These results suggest that both A- and B-type procyanidin oligomers in different Cinnamon species have hypoglycemic activities and may improve insulin sensitivity in type 2 DM. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/20851586/Hypoglycemic_activities_of_A__and_B_type_procyanidin_oligomer_rich_extracts_from_different_Cinnamon_barks_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(10)00262-X DB - PRIME DP - Unbound Medicine ER -