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Influence of ocular pulse amplitude on ocular response analyzer measurements.
J Glaucoma 2011; 20(6):344-9JG

Abstract

PURPOSE

To evaluate if the ocular pulse amplitude (OPA) (the difference between systolic and diastolic intraocular pressure) is associated with the measurement variability of IOPg [Goldmann-correlated intraocular pressure (IOP)], IOPcc (corneal compensated IOP), corneal hysteresis (CH), and corneal resistance factor (CRF) obtained from the ocular response analyzer (ORA).

METHODS

Sixty normal participants and 60 glaucoma patients were included. In 1 randomly selected eye in each participant, 4 repeated measurements were obtained with the ORA (Reichert Inc, Depew, NY) followed by OPA measurement by dynamic contour tonometry (Pascal; Swiss Microtechnology AG, Port, Switzerland). The repeatability of IOPg (a mathematically derived value with strong correlation with Goldmann applanation pressure measurement), IOPcc (a mathematically derived measurement less affected by corneal biomechanical properties), CH, and CRF were calculated. The associations between age, refraction, keratometry, central corneal thickness, axial length, OPA, and ORA measurements variability were evaluated with univariate and multivariate regression analyses.

RESULTS

The repeatability of IOPg, IOPcc, CRF, and CH were 4.08 (95% confidence interval: 3.06-5.09) mm Hg, 4.72 (3.54-5.89) mm Hg, 2.14 (1.61-2.68) mm Hg, 2.35 (1.77-2.94) mm Hg, respectively, for the normal group; and 4.18 (3.75-4.61) mm Hg, 5.56 (4.99-6.14) mm Hg, 2.17 (1.95-2.40) mm Hg, 2.78 (2.50-3.07) mm Hg, respectively, for the glaucoma group. Within-subject variances of IOPg and IOPcc, but not CRF and CH, were positively correlated with OPA. No association was found between age, refraction, keratometry, central corneal thickness, axial length, and the measurement variability of ORA.

CONCLUSIONS

The measurement reliability of ORA was only moderate. Eyes with large OPA were associated with high IOP measurement variability. Taking average of multiple repeated measurements is important for reliable measurement of ORA.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, The People's Republic of China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20852442

Citation

Xu, Guihua, et al. "Influence of Ocular Pulse Amplitude On Ocular Response Analyzer Measurements." Journal of Glaucoma, vol. 20, no. 6, 2011, pp. 344-9.
Xu G, Lam DS, Leung CK. Influence of ocular pulse amplitude on ocular response analyzer measurements. J Glaucoma. 2011;20(6):344-9.
Xu, G., Lam, D. S., & Leung, C. K. (2011). Influence of ocular pulse amplitude on ocular response analyzer measurements. Journal of Glaucoma, 20(6), pp. 344-9. doi:10.1097/IJG.0b013e3181efb388.
Xu G, Lam DS, Leung CK. Influence of Ocular Pulse Amplitude On Ocular Response Analyzer Measurements. J Glaucoma. 2011;20(6):344-9. PubMed PMID: 20852442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of ocular pulse amplitude on ocular response analyzer measurements. AU - Xu,Guihua, AU - Lam,Dennis Shun, AU - Leung,Christopher Kai-shun, PY - 2010/9/21/entrez PY - 2010/9/21/pubmed PY - 2011/11/5/medline SP - 344 EP - 9 JF - Journal of glaucoma JO - J. Glaucoma VL - 20 IS - 6 N2 - PURPOSE: To evaluate if the ocular pulse amplitude (OPA) (the difference between systolic and diastolic intraocular pressure) is associated with the measurement variability of IOPg [Goldmann-correlated intraocular pressure (IOP)], IOPcc (corneal compensated IOP), corneal hysteresis (CH), and corneal resistance factor (CRF) obtained from the ocular response analyzer (ORA). METHODS: Sixty normal participants and 60 glaucoma patients were included. In 1 randomly selected eye in each participant, 4 repeated measurements were obtained with the ORA (Reichert Inc, Depew, NY) followed by OPA measurement by dynamic contour tonometry (Pascal; Swiss Microtechnology AG, Port, Switzerland). The repeatability of IOPg (a mathematically derived value with strong correlation with Goldmann applanation pressure measurement), IOPcc (a mathematically derived measurement less affected by corneal biomechanical properties), CH, and CRF were calculated. The associations between age, refraction, keratometry, central corneal thickness, axial length, OPA, and ORA measurements variability were evaluated with univariate and multivariate regression analyses. RESULTS: The repeatability of IOPg, IOPcc, CRF, and CH were 4.08 (95% confidence interval: 3.06-5.09) mm Hg, 4.72 (3.54-5.89) mm Hg, 2.14 (1.61-2.68) mm Hg, 2.35 (1.77-2.94) mm Hg, respectively, for the normal group; and 4.18 (3.75-4.61) mm Hg, 5.56 (4.99-6.14) mm Hg, 2.17 (1.95-2.40) mm Hg, 2.78 (2.50-3.07) mm Hg, respectively, for the glaucoma group. Within-subject variances of IOPg and IOPcc, but not CRF and CH, were positively correlated with OPA. No association was found between age, refraction, keratometry, central corneal thickness, axial length, and the measurement variability of ORA. CONCLUSIONS: The measurement reliability of ORA was only moderate. Eyes with large OPA were associated with high IOP measurement variability. Taking average of multiple repeated measurements is important for reliable measurement of ORA. SN - 1536-481X UR - https://www.unboundmedicine.com/medline/citation/20852442/Influence_of_ocular_pulse_amplitude_on_ocular_response_analyzer_measurements_ L2 - http://Insights.ovid.com/pubmed?pmid=20852442 DB - PRIME DP - Unbound Medicine ER -