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Different characteristics of mitochondrial microsatellite instability between uterine leiomyomas and leiomyosarcomas.
Pathol Oncol Res. 2011 Jun; 17(2):201-5.PO

Abstract

Uterine leiomyomas are benign tumors of the uterus that arise clonally from smooth muscle cells of the myometrium and are the most common reason for hysterectomies. The aim of this study was to evaluate mitochondrial microsatellite instability (mtMSI) in uterine leiomyomas and leiomyosarcomas to clarify the molecular pathogenetic distinction between these tumors. DNA was isolated from paired normal and tumoral tissues in 50 patients with uterine leiomyomas and 14 patients with leiomyosarcomas. mtMSI was analyzed by using eight microsatellite markers. Our result showed that mitochondrial microsatellite instability was not found in all uterine leiomyomas. However, 3 (21.4%) of 14 patients with leiomyosarcomas had mtMSI and the frequencies of mtMSI in these tumors were significantly different (p < 0.01). Distinctive characteristics of mitochondrial genetic instability in uterine leiomyomas and leiomyosarcomas suggested the potential of mtMSI as a marker for differential diagnosis between them.

Authors+Show Affiliations

Department of Anatomy, School of Medicine, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20853077

Citation

Lee, Jae-Ho, et al. "Different Characteristics of Mitochondrial Microsatellite Instability Between Uterine Leiomyomas and Leiomyosarcomas." Pathology Oncology Research : POR, vol. 17, no. 2, 2011, pp. 201-5.
Lee JH, Ryu TY, Cho CH, et al. Different characteristics of mitochondrial microsatellite instability between uterine leiomyomas and leiomyosarcomas. Pathol Oncol Res. 2011;17(2):201-5.
Lee, J. H., Ryu, T. Y., Cho, C. H., & Kim, D. K. (2011). Different characteristics of mitochondrial microsatellite instability between uterine leiomyomas and leiomyosarcomas. Pathology Oncology Research : POR, 17(2), 201-5. https://doi.org/10.1007/s12253-010-9297-z
Lee JH, et al. Different Characteristics of Mitochondrial Microsatellite Instability Between Uterine Leiomyomas and Leiomyosarcomas. Pathol Oncol Res. 2011;17(2):201-5. PubMed PMID: 20853077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Different characteristics of mitochondrial microsatellite instability between uterine leiomyomas and leiomyosarcomas. AU - Lee,Jae-Ho, AU - Ryu,Tae-Yung, AU - Cho,Chi-Heum, AU - Kim,Dae-Kwang, Y1 - 2010/09/18/ PY - 2010/06/16/received PY - 2010/08/04/accepted PY - 2010/9/21/entrez PY - 2010/9/21/pubmed PY - 2011/9/29/medline SP - 201 EP - 5 JF - Pathology oncology research : POR JO - Pathol. Oncol. Res. VL - 17 IS - 2 N2 - Uterine leiomyomas are benign tumors of the uterus that arise clonally from smooth muscle cells of the myometrium and are the most common reason for hysterectomies. The aim of this study was to evaluate mitochondrial microsatellite instability (mtMSI) in uterine leiomyomas and leiomyosarcomas to clarify the molecular pathogenetic distinction between these tumors. DNA was isolated from paired normal and tumoral tissues in 50 patients with uterine leiomyomas and 14 patients with leiomyosarcomas. mtMSI was analyzed by using eight microsatellite markers. Our result showed that mitochondrial microsatellite instability was not found in all uterine leiomyomas. However, 3 (21.4%) of 14 patients with leiomyosarcomas had mtMSI and the frequencies of mtMSI in these tumors were significantly different (p < 0.01). Distinctive characteristics of mitochondrial genetic instability in uterine leiomyomas and leiomyosarcomas suggested the potential of mtMSI as a marker for differential diagnosis between them. SN - 1532-2807 UR - https://www.unboundmedicine.com/medline/citation/20853077/Different_characteristics_of_mitochondrial_microsatellite_instability_between_uterine_leiomyomas_and_leiomyosarcomas_ L2 - http://por.hu/2011/17/2/0201/0201a.pdf DB - PRIME DP - Unbound Medicine ER -