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Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus.
Am J Med Sci. 2010 Dec; 340(6):514-7.AJ

Abstract

Toxic hepatitis or drug-induced liver injury (DILI) encompasses a spectrum of conditions ranging from mild biochemical abnormalities to acute liver failure. Recent studies report that 35% to 48% of patients with diabetes use some form of complementary and alternative medical therapy. Moreover, >800 plants have been traditionally used for the treatment of diabetes. Despite this widespread use, only few were supported by rigorous clinical evidence. Gymnema sylvestre, also known as gurmar (sugar destroyer in Hindi), is a plant considered to be with potent antidiabetic effects and, hence, widely used in folk, ayurvedic and homeopathic systems in medicine. The authors were unable to find previous reports associating G sylvestre to liver injury. Herein, the authors report a case of DILI in a patient who was treated with G sylvestre for diabetes mellitus and review the literature to suggest possible mechanisms that led to this acute condition.

Authors+Show Affiliations

Department of Internal Medicine E, Soroka University Medical Center, Beer Sheva, Israel. arthur.shiyovich@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

20856101

Citation

Shiyovich, Arthur, et al. "Toxic Hepatitis Induced By Gymnema Sylvestre, a Natural Remedy for Type 2 Diabetes Mellitus." The American Journal of the Medical Sciences, vol. 340, no. 6, 2010, pp. 514-7.
Shiyovich A, Sztarkier I, Nesher L. Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus. Am J Med Sci. 2010;340(6):514-7.
Shiyovich, A., Sztarkier, I., & Nesher, L. (2010). Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus. The American Journal of the Medical Sciences, 340(6), 514-7. https://doi.org/10.1097/MAJ.0b013e3181f41168
Shiyovich A, Sztarkier I, Nesher L. Toxic Hepatitis Induced By Gymnema Sylvestre, a Natural Remedy for Type 2 Diabetes Mellitus. Am J Med Sci. 2010;340(6):514-7. PubMed PMID: 20856101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus. AU - Shiyovich,Arthur, AU - Sztarkier,Ignacio, AU - Nesher,Lior, PY - 2010/9/22/entrez PY - 2010/9/22/pubmed PY - 2011/1/7/medline SP - 514 EP - 7 JF - The American journal of the medical sciences JO - Am J Med Sci VL - 340 IS - 6 N2 - Toxic hepatitis or drug-induced liver injury (DILI) encompasses a spectrum of conditions ranging from mild biochemical abnormalities to acute liver failure. Recent studies report that 35% to 48% of patients with diabetes use some form of complementary and alternative medical therapy. Moreover, >800 plants have been traditionally used for the treatment of diabetes. Despite this widespread use, only few were supported by rigorous clinical evidence. Gymnema sylvestre, also known as gurmar (sugar destroyer in Hindi), is a plant considered to be with potent antidiabetic effects and, hence, widely used in folk, ayurvedic and homeopathic systems in medicine. The authors were unable to find previous reports associating G sylvestre to liver injury. Herein, the authors report a case of DILI in a patient who was treated with G sylvestre for diabetes mellitus and review the literature to suggest possible mechanisms that led to this acute condition. SN - 1538-2990 UR - https://www.unboundmedicine.com/medline/citation/20856101/Toxic_hepatitis_induced_by_Gymnema_sylvestre_a_natural_remedy_for_type_2_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9629(15)31435-X DB - PRIME DP - Unbound Medicine ER -