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[Rendu-Osler-Weber syndrome and cerebral infarction].
Ned Tijdschr Geneeskd. 2010; 154:A1185.NT

Abstract

A 30 year old man with a history of migraine presented at the neurology outpatient clinic with hypesthesia of the left side of his body during a migraine attack, which was unusual for him. His family history was positive for Rendu-Osler-Weber syndrome. MRI and magnetic resonance angiography (MRA) of the brain showed multiple small infarcts, without vascular malformations. CT angiography revealed an arteriovenous fistula in the lung. Rendu-Osler-Weber syndrome (or hereditary haemorrhagic telangiectasia, HHT) is an autosomal dominant condition affecting the blood vessels. It is estimated that about 60-80% of the patients with a pulmonary arteriovenous malformation (AVM) have HHT. Neurological complications include cerebral infarction and brain abscess. Also, there is a higher prevalence of migraine in patients with HHT, although the role that HHT plays in the pathogenesis of migraine is unclear. The treatment of choice of pulmonary AVM is endovascular treatment, with a success rate of 75% in the long term.

Authors+Show Affiliations

Atrium Medisch Centrum, Afd. Radiologie, Heerlen, the Netherlands. aaiberg@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

dut

PubMed ID

20858295

Citation

van den Berg, Aaike S., et al. "[Rendu-Osler-Weber Syndrome and Cerebral Infarction]." Nederlands Tijdschrift Voor Geneeskunde, vol. 154, 2010, pp. A1185.
van den Berg AS, Hijdra A, Reesink HJ, et al. [Rendu-Osler-Weber syndrome and cerebral infarction]. Ned Tijdschr Geneeskd. 2010;154:A1185.
van den Berg, A. S., Hijdra, A., Reesink, H. J., van Delden, O. M., & Majoie, C. B. (2010). [Rendu-Osler-Weber syndrome and cerebral infarction]. Nederlands Tijdschrift Voor Geneeskunde, 154, A1185.
van den Berg AS, et al. [Rendu-Osler-Weber Syndrome and Cerebral Infarction]. Ned Tijdschr Geneeskd. 2010;154:A1185. PubMed PMID: 20858295.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Rendu-Osler-Weber syndrome and cerebral infarction]. AU - van den Berg,Aaike S, AU - Hijdra,Albert, AU - Reesink,Herre J, AU - van Delden,Otto M, AU - Majoie,Charles B, PY - 2010/9/23/entrez PY - 2010/9/23/pubmed PY - 2010/10/16/medline SP - A1185 EP - A1185 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 154 N2 - A 30 year old man with a history of migraine presented at the neurology outpatient clinic with hypesthesia of the left side of his body during a migraine attack, which was unusual for him. His family history was positive for Rendu-Osler-Weber syndrome. MRI and magnetic resonance angiography (MRA) of the brain showed multiple small infarcts, without vascular malformations. CT angiography revealed an arteriovenous fistula in the lung. Rendu-Osler-Weber syndrome (or hereditary haemorrhagic telangiectasia, HHT) is an autosomal dominant condition affecting the blood vessels. It is estimated that about 60-80% of the patients with a pulmonary arteriovenous malformation (AVM) have HHT. Neurological complications include cerebral infarction and brain abscess. Also, there is a higher prevalence of migraine in patients with HHT, although the role that HHT plays in the pathogenesis of migraine is unclear. The treatment of choice of pulmonary AVM is endovascular treatment, with a success rate of 75% in the long term. SN - 1876-8784 UR - https://www.unboundmedicine.com/medline/citation/20858295/[Rendu_Osler_Weber_syndrome_and_cerebral_infarction]_ L2 - https://www.ntvg.nl/A1185 DB - PRIME DP - Unbound Medicine ER -