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Dietary iodine restriction in preparation for radioactive iodine treatment or scanning in well-differentiated thyroid cancer: a systematic review.
Thyroid 2010; 20(10):1129-38T

Abstract

BACKGROUND

Dietary iodine is often restricted before radioactive iodine (RAI) scanning or treatment of well-differentiated thyroid cancer. Our objective was to examine the impact of a low-iodine diet (LID) before RAI treatment or scanning on the following outcomes: (i) the efficacy of thyroid remnant ablation (or residual disease elimination), (ii) urinary iodine measurements, (iii) RAI kinetics, and (iv) long-term thyroid cancer outcomes.

METHODS

We performed a systematic review of the English literature. We searched four electronic databases and conducted a hand search. Two reviewers independently screened citations and reviewed full-text articles and reached consensus on included articles. Two reviewers independently abstracted data.

RESULTS

We reviewed 76 abstracts or citations and 26 full-text articles. Eight studies were included in the review. The most commonly studied diets allowed ≤ 50 µg/day of iodine for 1-2 weeks. In one study, 6-month successful remnant ablation rates were higher in patients following an LID than in controls. However, in another study, there was no significant benefit of an LID. LIDs reduce urinary iodine measurements and appear to increase I-131 uptake or lesional radiation compared to regular diets. No studies have examined long-term recurrence or mortality rates.

CONCLUSIONS

Given that LIDs reduce urinary iodine measurements, increase I-131 uptake, and possibly improve efficacy of I-131 treatment, we currently favor the use of a 1-2-week LID before I-131 therapy or scanning. However, more research is needed to clarify the role of this dietary intervention.

Authors+Show Affiliations

Division of Endocrinology, Department of Medicine, University Health Network, 200 Elizabeth St., Toronto, Ontario, Canada. sawkaam@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

20860420

Citation

Sawka, Anna M., et al. "Dietary Iodine Restriction in Preparation for Radioactive Iodine Treatment or Scanning in Well-differentiated Thyroid Cancer: a Systematic Review." Thyroid : Official Journal of the American Thyroid Association, vol. 20, no. 10, 2010, pp. 1129-38.
Sawka AM, Ibrahim-Zada I, Galacgac P, et al. Dietary iodine restriction in preparation for radioactive iodine treatment or scanning in well-differentiated thyroid cancer: a systematic review. Thyroid. 2010;20(10):1129-38.
Sawka, A. M., Ibrahim-Zada, I., Galacgac, P., Tsang, R. W., Brierley, J. D., Ezzat, S., & Goldstein, D. P. (2010). Dietary iodine restriction in preparation for radioactive iodine treatment or scanning in well-differentiated thyroid cancer: a systematic review. Thyroid : Official Journal of the American Thyroid Association, 20(10), pp. 1129-38. doi:10.1089/thy.2010.0055.
Sawka AM, et al. Dietary Iodine Restriction in Preparation for Radioactive Iodine Treatment or Scanning in Well-differentiated Thyroid Cancer: a Systematic Review. Thyroid. 2010;20(10):1129-38. PubMed PMID: 20860420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary iodine restriction in preparation for radioactive iodine treatment or scanning in well-differentiated thyroid cancer: a systematic review. AU - Sawka,Anna M, AU - Ibrahim-Zada,Irada, AU - Galacgac,Philip, AU - Tsang,Richard W, AU - Brierley,James D, AU - Ezzat,Shereen, AU - Goldstein,David P, PY - 2010/9/24/entrez PY - 2010/9/24/pubmed PY - 2011/1/21/medline SP - 1129 EP - 38 JF - Thyroid : official journal of the American Thyroid Association JO - Thyroid VL - 20 IS - 10 N2 - BACKGROUND: Dietary iodine is often restricted before radioactive iodine (RAI) scanning or treatment of well-differentiated thyroid cancer. Our objective was to examine the impact of a low-iodine diet (LID) before RAI treatment or scanning on the following outcomes: (i) the efficacy of thyroid remnant ablation (or residual disease elimination), (ii) urinary iodine measurements, (iii) RAI kinetics, and (iv) long-term thyroid cancer outcomes. METHODS: We performed a systematic review of the English literature. We searched four electronic databases and conducted a hand search. Two reviewers independently screened citations and reviewed full-text articles and reached consensus on included articles. Two reviewers independently abstracted data. RESULTS: We reviewed 76 abstracts or citations and 26 full-text articles. Eight studies were included in the review. The most commonly studied diets allowed ≤ 50 µg/day of iodine for 1-2 weeks. In one study, 6-month successful remnant ablation rates were higher in patients following an LID than in controls. However, in another study, there was no significant benefit of an LID. LIDs reduce urinary iodine measurements and appear to increase I-131 uptake or lesional radiation compared to regular diets. No studies have examined long-term recurrence or mortality rates. CONCLUSIONS: Given that LIDs reduce urinary iodine measurements, increase I-131 uptake, and possibly improve efficacy of I-131 treatment, we currently favor the use of a 1-2-week LID before I-131 therapy or scanning. However, more research is needed to clarify the role of this dietary intervention. SN - 1557-9077 UR - https://www.unboundmedicine.com/medline/citation/20860420/Dietary_iodine_restriction_in_preparation_for_radioactive_iodine_treatment_or_scanning_in_well_differentiated_thyroid_cancer:_a_systematic_review_ L2 - https://www.liebertpub.com/doi/full/10.1089/thy.2010.0055?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -