Tags

Type your tag names separated by a space and hit enter

The effect of actinoquinol with hyaluronic acid in eye drops on the optical properties and oxidative damage of the rabbit cornea irradiated with UVB rays.
Photochem Photobiol. 2010 Nov-Dec; 86(6):1294-306.PP

Abstract

Irradiation of the cornea with UVB rays leads to its oxidative damage, swelling and increased light absorption. We investigated changes in the corneal optics (evaluated by changes of corneal hydration and light absorption) and microscopical disturbances of corneas irradiated with UVB rays as influenced by eye drops containing actinoquinol with hyaluronic acid. Rabbit corneas were irradiated with a daily dose of 0.5 or 1.01 J cm(-2) of UVB rays (312 nm) for 4 days. During irradiation, the eye drops were applied on the right eye and buffered saline (or hyaluronic acid) on the left eye. On day 5 the rabbits were sacrificed and the corneas examined spectrophotometrically for light absorption. The corneal thickness (hydration) was measured using a pachymeter. Corneas of some other rabbits were examined immunohistochemically. After buffered saline treatment UVB rays evoked changes in the corneal optics and induced oxidative damage of the corneas. After actinoquinol-hyaluronic acid application, these changes were diminished. Hyaluronic acid alone was less effective. In conclusion, actinoquinol-hyaluronic acid eye drops decreased changes in corneal optics and suppressed oxidative damage in the UVB-irradiated cornea. However, the effective corneal protection by these eye drops was limited to the lower UVB dose.

Authors+Show Affiliations

Laboratory of Eye Histochemistry and Pharmacology, Institute of Experimental Medicine, Center of Excellence, Academy of Sciences of the Czech Republic, Prague, Czech Republic.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20860695

Citation

Čejka, Čestmír, et al. "The Effect of Actinoquinol With Hyaluronic Acid in Eye Drops On the Optical Properties and Oxidative Damage of the Rabbit Cornea Irradiated With UVB Rays." Photochemistry and Photobiology, vol. 86, no. 6, 2010, pp. 1294-306.
Čejka Č, Luyckx J, Ardan T, et al. The effect of actinoquinol with hyaluronic acid in eye drops on the optical properties and oxidative damage of the rabbit cornea irradiated with UVB rays. Photochem Photobiol. 2010;86(6):1294-306.
Čejka, Č., Luyckx, J., Ardan, T., Pláteník, J., Širc, J., Michálek, J., & Čejková, J. (2010). The effect of actinoquinol with hyaluronic acid in eye drops on the optical properties and oxidative damage of the rabbit cornea irradiated with UVB rays. Photochemistry and Photobiology, 86(6), 1294-306. https://doi.org/10.1111/j.1751-1097.2010.00796.x
Čejka Č, et al. The Effect of Actinoquinol With Hyaluronic Acid in Eye Drops On the Optical Properties and Oxidative Damage of the Rabbit Cornea Irradiated With UVB Rays. Photochem Photobiol. 2010 Nov-Dec;86(6):1294-306. PubMed PMID: 20860695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of actinoquinol with hyaluronic acid in eye drops on the optical properties and oxidative damage of the rabbit cornea irradiated with UVB rays. AU - Čejka,Čestmír, AU - Luyckx,Jacques, AU - Ardan,Taras, AU - Pláteník,Jan, AU - Širc,Jakub, AU - Michálek,Jiří, AU - Čejková,Jitka, Y1 - 2010/09/22/ PY - 2010/9/24/entrez PY - 2010/9/24/pubmed PY - 2011/3/22/medline SP - 1294 EP - 306 JF - Photochemistry and photobiology JO - Photochem Photobiol VL - 86 IS - 6 N2 - Irradiation of the cornea with UVB rays leads to its oxidative damage, swelling and increased light absorption. We investigated changes in the corneal optics (evaluated by changes of corneal hydration and light absorption) and microscopical disturbances of corneas irradiated with UVB rays as influenced by eye drops containing actinoquinol with hyaluronic acid. Rabbit corneas were irradiated with a daily dose of 0.5 or 1.01 J cm(-2) of UVB rays (312 nm) for 4 days. During irradiation, the eye drops were applied on the right eye and buffered saline (or hyaluronic acid) on the left eye. On day 5 the rabbits were sacrificed and the corneas examined spectrophotometrically for light absorption. The corneal thickness (hydration) was measured using a pachymeter. Corneas of some other rabbits were examined immunohistochemically. After buffered saline treatment UVB rays evoked changes in the corneal optics and induced oxidative damage of the corneas. After actinoquinol-hyaluronic acid application, these changes were diminished. Hyaluronic acid alone was less effective. In conclusion, actinoquinol-hyaluronic acid eye drops decreased changes in corneal optics and suppressed oxidative damage in the UVB-irradiated cornea. However, the effective corneal protection by these eye drops was limited to the lower UVB dose. SN - 1751-1097 UR - https://www.unboundmedicine.com/medline/citation/20860695/The_effect_of_actinoquinol_with_hyaluronic_acid_in_eye_drops_on_the_optical_properties_and_oxidative_damage_of_the_rabbit_cornea_irradiated_with_UVB_rays_ L2 - https://doi.org/10.1111/j.1751-1097.2010.00796.x DB - PRIME DP - Unbound Medicine ER -